7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang Y et al. | Cyanidin-3-O-β-glucoside induces oxysterol efflux from endothelial cells: role of liver X receptor alpha. | 2012 | Atherosclerosis | pmid:22749359 |
| Guyton JR et al. | Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. | 1995 | Atherosclerosis | pmid:8770318 |
| Englund MC et al. | 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages. | 2001 | Atherosclerosis | pmid:11500175 |
| Myers SJ and Stanley KK | Src family kinase activation in glycosphingolipid-rich membrane domains of endothelial cells treated with oxidised low density lipoprotein. | 1999 | Atherosclerosis | pmid:10217369 |
| Urano Y et al. | Vascular smooth muscle cell outgrowth, proliferation, and apoptosis in young and old rats. | 1999 | Atherosclerosis | pmid:10487492 |
| Dulak J et al. | Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation. | 2001 | Atherosclerosis | pmid:11730812 |
| Sleer LS et al. | Interaction of caveolin with 7-ketocholesterol. | 2001 | Atherosclerosis | pmid:11689206 |
| Deckert V et al. | Prevention of LDL alpha-tocopherol consumption, cholesterol oxidation, and vascular endothelium dysfunction by polyphenolic compounds from red wine. | 2002 | Atherosclerosis | pmid:12208469 |
| Tamasawa N et al. | Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver. | 1997 | Atherosclerosis | pmid:9199277 |
| Hwee Ming Cheng and Kalyana Sundram | Cholesterol oxides and natural autoantibodies. | 1998 | Atherosclerosis | pmid:9862183 |
| Rosales C et al. | CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ. | 2015 | Atherosclerosis | pmid:25618030 |
| Gerry AB et al. | A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein. | 2008 | Atherosclerosis | pmid:17945239 |
| Lee HS et al. | TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15993097 |
| Kosykh VA et al. | 7-ketocholesterol inhibits VLDL secretion by cultured human and rabbit hepatocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3390173 |
| Khatib S and Vaya J | Oxysterols and symptomatic versus asymptomatic human atherosclerotic plaque. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24393847 |
| Levy D et al. | Short-term effects of 7-ketocholesterol on human adipose tissue mesenchymal stem cells in vitro. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24491549 |
| Nagayama D et al. | Effects of serotonin on expression of the LDL receptor family member LR11 and 7-ketocholesterol-induced apoptosis in human vascular smooth muscle cells. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24650663 |
| Thewke D et al. | AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19338772 |
| Nury T et al. | Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: impairment by α-tocopherol. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24299956 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| Nishio E et al. | Oxidized LDL induces apoptosis in cultured smooth muscle cells: a possible role for 7-ketocholesterol. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8670295 |
| Nishio E and Watanabe Y | Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8831713 |
| Li W et al. | Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621514 |
| Murphy PR et al. | Binding of oxygenated cholesterol metabolites to antiestrogen binding sites from chicken liver. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985957 |
| Cho HR et al. | 7-Oxygenated cholesterol molecules differentially affect the expression of zonula occludens-1 in vascular smooth muscle cells and monocyte/macrophage cells. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29428726 |
| Netherland C and Thewke DP | Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20609360 |
| Rodriguez-Estrada MT et al. | 7-Ketocholesterol as marker of cholesterol oxidation in model and food systems: when and how. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24589732 |
| Son Y et al. | 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25576871 |
| Noguchi N et al. | Diverse functions of 24(S)-hydroxycholesterol in the brain. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24530911 |
| Akiba S et al. | Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14521937 |
| Williams JC et al. | Defective catabolism of low-density lipoprotein by fibroblasts from patients with I-cell disease. | 1982 | Biochem. J. | pmid:7082306 |
| Slotte JP et al. | Uptake and esterification of exogenous cholesterol by low-density-lipoprotein-receptor-negative human fibroblasts in culture. | 1984 | Biochem. J. | pmid:6487273 |
| Hamilton JA et al. | Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL. | 2001 | Biochem. J. | pmid:11256965 |
| Millanvoye-Van Brussel E et al. | Lysophosphatidylcholine and 7-oxocholesterol modulate Ca2+ signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2. | 2004 | Biochem. J. | pmid:14992685 |
| Wang SF et al. | 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. | 2013 | Biochem. Pharmacol. | pmid:23792120 |
| Buttari B et al. | 7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages. | 2013 | Biochem. Pharmacol. | pmid:23611834 |
| Miguet-Alfonsi C et al. | Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. | 2002 | Biochem. Pharmacol. | pmid:12147305 |
| Jeng I et al. | Effect of a hypocholesterolemic agent on cholesteryl ester metabolism in glioblastoma cells. | 1985 | Biochem. Pharmacol. | pmid:3994747 |
| Geng YJ et al. | Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and rupture. | 2003 | Biochem. Pharmacol. | pmid:14555225 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. | 2013 | Biochem. Pharmacol. | pmid:23415904 |
| Ragot K et al. | Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23473804 |
| Huggett CD et al. | Plasma VLDL cholesterol and egg cholesterol are resistant to change in the laying hen. | 1993 | Biochem. Soc. Trans. | pmid:8359401 |
| Bravo E and Napolitano M | Mechanisms involved in chylomicron remnant lipid uptake by macrophages. | 2007 | Biochem. Soc. Trans. | pmid:17511627 |
| Bach D et al. | Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine. | 2008 | Biochemistry | pmid:18247524 |
| Wang J et al. | Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): implications for lipid raft structure and function. | 2004 | Biochemistry | pmid:14744146 |
| Gaus K et al. | A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1. | 2001 | Biochemistry | pmid:11478905 |
| Satchell L and Leake DS | Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis. | 2012 | Biochemistry | pmid:22493939 |
| Massey JB and Pownall HJ | The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I. | 2005 | Biochemistry | pmid:16042420 |
| Gaus K et al. | Inhibition of cholesterol efflux by 7-ketocholesterol: comparison between cells, plasma membrane vesicles, and liposomes as cholesterol donors. | 2001 | Biochemistry | pmid:11669638 |
| Vestergaard MC et al. | The effect of oxycholesterols on thermo-induced membrane dynamics. | 2011 | Biochim. Biophys. Acta | pmid:21600872 |