7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Song W et al. | Endogenous 7-oxocholesterol is an enzymatic product: characterization of 7 alpha-hydroxycholesterol dehydrogenase activity of hamster liver microsomes. | 1996 | Arch. Biochem. Biophys. | pmid:8645004 |
| Pinchuk I and Lichtenberg D | Continuous monitoring of intermediates and final products of oxidation of low density lipoprotein by means of UV-spectroscopy. | 1996 | Free Radic. Res. | pmid:8733939 |
| Gelissen IC et al. | Sterol efflux is impaired from macrophage foam cells selectively enriched with 7-ketocholesterol. | 1996 | J. Biol. Chem. | pmid:8663356 |
| Palladini G et al. | Disruption of actin microfilament organization by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635497 |
| Palladini G et al. | Modifications of vimentin filament architecture and vimentin-nuclear interactions by cholesterol oxides in 73/73 endothelial cells. | 1996 | Exp. Cell Res. | pmid:8635498 |
| Patel RP et al. | Formation of oxysterols during oxidation of low density lipoprotein by peroxynitrite, myoglobin, and copper. | 1996 | J. Lipid Res. | pmid:8978488 |
| Brown AJ et al. | Free and esterified oxysterol: formation during copper-oxidation of low density lipoprotein and uptake by macrophages. | 1996 | J. Lipid Res. | pmid:9026530 |
| Kritharides L et al. | Hydroxypropyl-beta-cyclodextrin-mediated efflux of 7-ketocholesterol from macrophage foam cells. | 1996 | J. Biol. Chem. | pmid:8910326 |
| Harada K et al. | Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway. | 1997 | FEBS Lett. | pmid:9247143 |
| Gesquière L et al. | Impaired cellular cholesterol efflux by oxysterol-enriched high density lipoproteins. | 1997 | Free Radic. Biol. Med. | pmid:9215799 |
| Krut LH et al. | The effect of oxidizing cholesterol on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9108794 |
| Lizard G et al. | Induction of similar features of apoptosis in human and bovine vascular endothelial cells treated by 7-ketocholesterol. | 1997 | J. Pathol. | pmid:9422990 |
| Dyer RG et al. | 7-ketocholesterol, a specific indicator of lipoprotein oxidation, and malondialdehyde in non-insulin dependent diabetes and peripheral vascular disease. | 1997 | Clin. Chim. Acta | pmid:9101096 |
| Lizard G et al. | Induction of apoptosis and of interleukin-1beta secretion by 7beta-hydroxycholesterol and 7-ketocholesterol: partial inhibition by Bcl-2 overexpression. | 1997 | FEBS Lett. | pmid:9428650 |
| Deckert V et al. | Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins. Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. | 1997 | Circulation | pmid:9024163 |
| Tamasawa N et al. | Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver. | 1997 | Atherosclerosis | pmid:9199277 |
| Zhang Q et al. | [Quantitative determination of 7-ketocholesterol in human fetal liver cell supernatant and lysate by high performance liquid chromatography]. | 1997 | Se Pu | pmid:15739446 |
| McCourt MP et al. | X-ray crystal structure of cytotoxic oxidized cholesterols: 7-ketocholesterol and 25-hydroxycholesterol. | 1997 | J. Lipid Res. | pmid:9186918 |
| Vine DF et al. | Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits. | 1998 | J. Lipid Res. | pmid:9788246 |
| Hakamata H et al. | Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein. | 1998 | J. Lipid Res. | pmid:9548582 |
| Cantwell H and Devery R | The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox. | 1998 | Cell Biol. Toxicol. | pmid:9879932 |
| Lizard G et al. | Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production. | 1998 | FASEB J. | pmid:9837855 |
| Lemaire S et al. | Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol. | 1998 | FEBS Lett. | pmid:9872417 |
| Dushkin M et al. | Effects of oxysterols upon macrophage and lymphocyte functions in vitro. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9644113 |
| Hakamata H et al. | Cytotoxic effect of oxidized low density lipoprotein on macrophages. | 1998 | J. Atheroscler. Thromb. | pmid:10855560 |
| Pinchuk I et al. | Kinetic analysis of copper-induced peroxidation of LDL. | 1998 | Biochim. Biophys. Acta | pmid:9461257 |
| Hwee Ming Cheng and Kalyana Sundram | Cholesterol oxides and natural autoantibodies. | 1998 | Atherosclerosis | pmid:9862183 |
| Linseisen J and Wolfram G | Absorption of cholesterol oxidation products from ordinary foodstuff in humans. | 1998 | Ann. Nutr. Metab. | pmid:9745108 |
| Deckert V et al. | Inhibition by cholesterol oxides of NO release from human vascular endothelial cells. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672065 |
| Myers SJ and Stanley KK | Src family kinase activation in glycosphingolipid-rich membrane domains of endothelial cells treated with oxidised low density lipoprotein. | 1999 | Atherosclerosis | pmid:10217369 |
| van Reyk DM et al. | Prooxidant and antioxidant activities of macrophages in metal-mediated LDL oxidation: the importance of metal sequestration. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195944 |
| Zarev S et al. | Major differences in oxysterol formation in human low density lipoproteins (LDLs) oxidized by *OH/O2*- free radicals or by copper. | 1999 | FEBS Lett. | pmid:10371147 |
| Gelissen IC et al. | Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid. | 1999 | J. Lipid Res. | pmid:10484610 |
| Urano Y et al. | Vascular smooth muscle cell outgrowth, proliferation, and apoptosis in young and old rats. | 1999 | Atherosclerosis | pmid:10487492 |
| Lizard G et al. | Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10323769 |
| Pirillo A et al. | Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells. | 1999 | FEBS Lett. | pmid:10580102 |
| Inouye M et al. | Glycated hemoglobin and lipid peroxidation in erythrocytes of diabetic patients. | 1999 | Metab. Clin. Exp. | pmid:10024083 |
| Rao ML et al. | Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672272 |
| Lyons MA et al. | Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols. | 1999 | J. Lipid Res. | pmid:10508204 |
| Lyons MA and Brown AJ | 7-Ketocholesterol. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224662 |
| Norlin M et al. | 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | 2000 | J. Lipid Res. | pmid:11013305 |
| Brown AJ et al. | Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. | 2000 | J. Lipid Res. | pmid:10681406 |
| Bourdon E et al. | Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116066 |
| Lizard G et al. | Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. | 2000 | Free Radic. Biol. Med. | pmid:10754270 |
| Abo K et al. | Comparative analysis of plasma and erythrocyte 7-ketocholesterol as a marker for oxidative stress in patients with diabetes mellitus. | 2000 | Clin. Biochem. | pmid:11124339 |
| Perségol L et al. | Co-incubation of native and oxidized low-density lipoproteins: potentiation of relaxation impairment. | 2000 | Eur. J. Pharmacol. | pmid:11040350 |
| Liao HS et al. | Expression of class A scavenger receptor inhibits apoptosis of macrophages triggered by oxidized low density lipoprotein and oxysterol. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10938019 |
| Brown AJ et al. | Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. | 2000 | J. Biol. Chem. | pmid:10869358 |
| Yoshida T et al. | Cholestan-3beta,5alpha,6beta-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cells. | 2000 | FEBS Lett. | pmid:10922480 |
| Tsuzuki D et al. | Analysis of 7-ketocholesterol in low density lipoprotein and fatty acid composition in erythrocyte membranes of patients on maintenance hemodialysis and healthy controls. | 2000 | Clin. Chim. Acta | pmid:10767401 |