7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Aye IL et al. | Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity. | 2010 | Biochim. Biophys. Acta | pmid:20570635 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Crow JA et al. | Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. | 2010 | Biochim. Biophys. Acta | pmid:19761868 |
| Kim WK et al. | Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. | 2010 | J. Bone Miner. Res. | pmid:19839776 |
| Chien JT et al. | Integral kinetic model for studying quercetin degradation and oxidation as affected by cholesterol during heating. | 2010 | Int J Mol Sci | pmid:21152275 |
| Mascia C et al. | Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate. | 2010 | Free Radic. Biol. Med. | pmid:20923702 |
| Ong WY et al. | Changes in brain cholesterol metabolome after excitotoxicity. | 2010 | Mol. Neurobiol. | pmid:20140539 |
| Deiana M et al. | Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. | 2010 | Food Chem. Toxicol. | pmid:20691238 |
| Wang Y et al. | Isolation and identification of two steroid compounds from Oviductus Ranae. | 2010 | Nat. Prod. Res. | pmid:20835952 |
| Janoszka B | 7-Ketocholesterol and 7-hydroxycholesterol in pork meat and its gravy thermally treated without additives and in the presence of onion and garlic. | 2010 | Meat Sci. | pmid:20822860 |
| RodrÃguez IR and Larrayoz IM | Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration. | 2010 | J. Lipid Res. | pmid:20567027 |
| Favero GM et al. | Synthetic nanoemulsion resembling a protein-free model of 7-ketocholesterol containing low density lipoprotein: In vitro and in vivo studies. | 2010 | Biol. Res. | pmid:21526270 |
| Liao PL et al. | 7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways. | 2010 | Toxicol. Lett. | pmid:20466046 |
| Seimon TA et al. | Induction of ER stress in macrophages of tuberculosis granulomas. | 2010 | PLoS ONE | pmid:20856677 |
| Zabirnyk O et al. | Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy. | 2010 | Carcinogenesis | pmid:19942609 |
| Li D et al. | Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20395595 |
| Gramajo AL et al. | Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19834037 |
| Anticoli S et al. | 7-ketocholesterol and 5,6-secosterol modulate differently the stress-activated mitogen-activated protein kinases (MAPKs) in liver cells. | 2010 | J. Cell. Physiol. | pmid:19937729 |
| Kim YJ and Lee CS | Tyrosine kinase inhibitor AG126 reduces 7-ketocholesterol-induced cell death by suppressing mitochondria-mediated apoptotic process. | 2010 | Neurochem. Res. | pmid:19957203 |
| Seet RC et al. | Oxidative damage in Parkinson disease: Measurement using accurate biomarkers. | 2010 | Free Radic. Biol. Med. | pmid:19969070 |
| Kathir K et al. | Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and nondiabetic subjects. | 2010 | Free Radic. Biol. Med. | pmid:20478379 |
| Suzuki K et al. | Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. | 2010 | J. Periodont. Res. | pmid:20412422 |
| Mintzer E et al. | Interaction of two oxysterols, 7-ketocholesterol and 25-hydroxycholesterol, with phosphatidylcholine and sphingomyelin in model membranes. | 2010 | Chem. Phys. Lipids | pmid:20471966 |
| Mathieu JM et al. | 7-ketocholesterol catabolism by Rhodococcus jostii RHA1. | 2010 | Appl. Environ. Microbiol. | pmid:19880645 |
| Palozza P et al. | Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. | 2010 | J. Nutr. Biochem. | pmid:19157829 |
| Rodriguez IR and Fliesler SJ | Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism. | 2009 Sep-Oct | Photochem. Photobiol. | pmid:19500292 |
| Haider N et al. | Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis. | 2009 Sep-Oct | J Nucl Cardiol | pmid:19662466 |
| Loru D et al. | Protective effect of hydroxytyrosol and tyrosol against oxidative stress in kidney cells. | 2009 May-Jun | Toxicol Ind Health | pmid:19651801 |
| Lee WH et al. | 7-ketocholesterol induces endoplasmic reticulum stress in HT-29 cells. | 2009 Mar-Apr | Z. Naturforsch., C, J. Biosci. | pmid:19526729 |
| Sankaranarayanan S et al. | Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. | 2009 | J. Lipid Res. | pmid:18827283 |
| Mazalli MR and Bragagnolo N | Increase of cholesterol oxidation and decrease of PUFA as a result of thermal processing and storage in eggs enriched with n-3 fatty acids. | 2009 | J. Agric. Food Chem. | pmid:19438228 |
| German JB et al. | A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk. | 2009 | Eur J Nutr | pmid:19259609 |
| Vejux A et al. | Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis. | 2009 | J. Nutr. Biochem. | pmid:18495460 |
| Kell DB | Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. | 2009 | BMC Med Genomics | pmid:19133145 |
| Pilotelle-Bunner A et al. | The local electric field within phospholipid membranes modulates the charge transfer reactions in reaction centres. | 2009 | Biochim. Biophys. Acta | pmid:19306840 |
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| Thewke D et al. | AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19338772 |
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |
| Sanson M et al. | Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. | 2009 | Circ. Res. | pmid:19106412 |
| Kahn E et al. | Analysis of the capture and influence of nanoparticles on the cytotoxic effects of 7-ketocholesterol on cardiac cells: investigation by flow cytometry and by dynamic and spectral imaging microscopy associated with factor analysis of medical image sequences. | 2009 | Anal. Quant. Cytol. Histol. | pmid:20698354 |
| He X et al. | Apolipoprotein D modulates F2-isoprostane and 7-ketocholesterol formation and has a neuroprotective effect on organotypic hippocampal cultures after kainate-induced excitotoxic injury. | 2009 | Neurosci. Lett. | pmid:19429117 |
| Royer MC et al. | 7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death. | 2009 | J. Biol. Chem. | pmid:19351882 |
| Matsunaga I et al. | Determination of oxysterols in oxidatively modified low-density lipoprotein by semi-micro high-performance liquid chromatography with electrochemical detection. | 2009 | Anal. Biochem. | pmid:19563770 |
| Katsogiannou M et al. | Caveolae contribute to the apoptosis resistance induced by the alpha(1A)-adrenoceptor in androgen-independent prostate cancer cells. | 2009 | PLoS ONE | pmid:19763272 |
| Moreira EF et al. | 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:18936140 |
| Balázs Z et al. | Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. | 2009 | Mol. Cell. Endocrinol. | pmid:19010388 |
| Harder T and Sangani D | Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. | 2009 | Cell Commun. Signal | pmid:19732448 |
| Mathieu JM et al. | Medical bioremediation of age-related diseases. | 2009 | Microb. Cell Fact. | pmid:19358742 |
| Hitsumoto T et al. | Clinical significance of serum 7-ketocholesterol concentrations in the progression of coronary atherosclerosis. | 2009 | J. Atheroscler. Thromb. | pmid:19672027 |
| Sung SC et al. | 7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells. | 2009 | J. Vasc. Res. | pmid:18515973 |
| Javitt NB and Javitt JC | The retinal oxysterol pathway: a unifying hypothesis for the cause of age-related macular degeneration. | 2009 | Curr Opin Ophthalmol | pmid:19390436 |
| Perales S et al. | Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. | 2009 | J. Biomed. Biotechnol. | pmid:19727411 |
| Liu J et al. | Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. | 2009 | Arch. Biochem. Biophys. | pmid:19464253 |
| Wielkoszyński T et al. | Concentration of anti-7-ketocholesterol antibodies in patient sera after heart transplantation. | 2009 | Transplant. Proc. | pmid:19857711 |
| Huang ZY et al. | [The apoptosis of mouse macrophage J774A.1 induced by oxysterol depend on NF-kappaB activation]. | 2009 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:19811731 |
| Iuliano L et al. | Association of cholesterol oxidation and abnormalities in fatty acid metabolism in cystic fibrosis. | 2009 | Am. J. Clin. Nutr. | pmid:19587087 |
| Kim DE et al. | Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change. | 2009 | Neurochem. Res. | pmid:19224363 |
| Ingueneau C et al. | TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells. | 2009 | J. Cell. Mol. Med. | pmid:20187291 |
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| Kratzer A et al. | Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia. | 2009 | J. Lipid Res. | pmid:18812595 |
| Kuehnle K et al. | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. | 2009 | Neurochem. Res. | pmid:19115107 |
| Xu G et al. | Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants. | 2009 | J. Agric. Food Chem. | pmid:19754120 |
| Rentero C et al. | Functional implications of plasma membrane condensation for T cell activation. | 2008 | PLoS ONE | pmid:18509459 |
| Saito E et al. | 7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cells. | 2008 | J. Atheroscler. Thromb. | pmid:18603819 |
| Martinet W et al. | Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells. | 2008 | Br. J. Pharmacol. | pmid:18469840 |
| Deiana M et al. | Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells. | 2008 | Food Chem. Toxicol. | pmid:18588937 |
| Bach D et al. | Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine. | 2008 | Biochemistry | pmid:18247524 |
| Rosa A et al. | Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. | 2008 | Chem. Phys. Lipids | pmid:18498764 |
| Borlak J and Jenke HS | Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation. | 2008 | Mol. Cancer Res. | pmid:18708364 |
| Noguchi N | Role of oxidative stress in adaptive responses in special reference to atherogenesis. | 2008 | J Clin Biochem Nutr | pmid:19015746 |
| Lee CY et al. | Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. | 2008 | Free Radic. Biol. Med. | pmid:18226605 |
| Vejux A et al. | Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis. | 2008 | Braz. J. Med. Biol. Res. | pmid:18719735 |
| Terasaka N et al. | ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. | 2008 | J. Clin. Invest. | pmid:18924609 |
| Kim DH and Frangos JA | Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols. | 2008 | Biophys. J. | pmid:18390616 |
| Rosa A et al. | Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture. | 2008 | J. Agric. Food Chem. | pmid:18439017 |
| Freeman-Anderson NE et al. | Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. | 2008 | J. Lipid Res. | pmid:18614816 |
| Soustelle L et al. | UV laser mediated cell selective destruction by confocal microscopy. | 2008 | Neural Dev | pmid:18442390 |
| Mizukami M et al. | Proteome profiling of embryo chick retina. | 2008 | Proteome Sci | pmid:18208622 |
| Ferioli F et al. | Evaluation of cholesterol and lipid oxidation in raw and cooked minced beef stored under oxygen-enriched atmosphere. | 2008 | Meat Sci. | pmid:22063582 |
| Alkazemi D et al. | Oxysterol as a marker of atherogenic dyslipidemia in adolescence. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18713821 |
| Wamil M et al. | 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. | 2008 | Endocrinology | pmid:18755798 |
| Gerry AB et al. | A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein. | 2008 | Atherosclerosis | pmid:17945239 |
| Luthra S et al. | 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro. | 2008 | Microvasc. Res. | pmid:18068200 |
| Romeo GR and Kazlauskas A | Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. | 2008 | J. Biol. Chem. | pmid:18230613 |
| Endo K et al. | Determination of serum 7-ketocholesterol concentrations and their relationships with coronary multiple risks in diabetes mellitus. | 2008 | Diabetes Res. Clin. Pract. | pmid:18207277 |
| Hans CP et al. | Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. | 2008 | Cardiovasc. Res. | pmid:18245064 |
| Guo Z et al. | Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. | 2008 | Free Radic. Biol. Med. | pmid:18215741 |
| Saitoh E et al. | [Variance of expressions of extracellular matrix components and effects of anti-osteoporotic drugs on Mönckeberg's arteriosclerosis]. | 2008 | Yakugaku Zasshi | pmid:18311057 |
| Mathieu J et al. | Microbial degradation of 7-ketocholesterol. | 2008 | Biodegradation | pmid:18344006 |
| Palozza P et al. | The protective role of carotenoids against 7-keto-cholesterol formation in solution. | 2008 | Mol. Cell. Biochem. | pmid:18008144 |
| Lee CS et al. | Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers. | 2007 | Neurochem. Res. | pmid:17151911 |
| Rittmann BE and Schloendorn J | Engineering away lysosomal junk: medical bioremediation. | 2007 | Rejuvenation Res | pmid:17708688 |
| Palozza P et al. | Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages. | 2007 | Free Radic. Biol. Med. | pmid:17448905 |
| Nashev LG et al. | Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. | 2007 | PLoS ONE | pmid:17593962 |
| Fülöp T et al. | Immunosupportive therapies in aging. | 2007 | Clin Interv Aging | pmid:18044074 |
| Kim JS et al. | Cytoprotective effect of polysaccharide isolated from different mushrooms against 7-ketocholesterol induced damage in mouse liver cell line (BNL CL. 2). | 2007 | Nutr Res Pract | pmid:20368935 |
| Myoishi M et al. | Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. | 2007 | Circulation | pmid:17709641 |
| Vejux A et al. | Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: investigation by flow cytometry and spectral imaging microscopy. | 2007 | Cytometry A | pmid:17458884 |
| Farooqui AA et al. | Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. | 2007 | Brain Res Rev | pmid:17959252 |
| Deiana M et al. | Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate. | 2007 | Food Chem. Toxicol. | pmid:17686562 |