7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Guina T et al. | The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics. | 2015 | Food Funct | pmid:25736858 |
| Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
| Telesford DM et al. | Reduced Condensing and Ordering Effects by 7-Ketocholesterol and 5β,6β-Epoxycholesterol on DPPC Monolayers. | 2015 | Langmuir | pmid:26322794 |
| Luchetti F et al. | 7-Ketocholesterol and 5,6-secosterol induce human endothelial cell dysfunction by differential mechanisms. | 2015 | Steroids | pmid:25697053 |
| Karilainen T et al. | Oxidation of cholesterol does not alter significantly its uptake into high-density lipoprotein particles. | 2015 | J Phys Chem B | pmid:25768721 |
| Chen Y et al. | THP1 macrophages oxidized cholesterol, generating 7-derivative oxysterols specifically released by HDL. | 2015 | Steroids | pmid:25742736 |
| Rosales C et al. | CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ. | 2015 | Atherosclerosis | pmid:25618030 |
| Pajares S et al. | Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency. | 2015 | J. Lipid Res. | pmid:26239048 |
| Davis S et al. | α-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein. | 2015 | J. Lipid Res. | pmid:26026069 |
| Moinard C et al. | Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. | 2015 | J. Nutr. | pmid:26019250 |
| Indaram M et al. | 7-Ketocholesterol increases retinal microglial migration, activation, and angiogenicity: a potential pathogenic mechanism underlying age-related macular degeneration. | 2015 | Sci Rep | pmid:25775051 |
| Shi G et al. | Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18. | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:25678688 |
| Lee JW et al. | Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL. | 2015 | Biochim. Biophys. Acta | pmid:25617738 |
| Laparra JM et al. | 7keto-stigmasterol and 7keto-cholesterol induce differential proteome changes to intestinal epitelial (Caco-2) cells. | 2015 | Food Chem. Toxicol. | pmid:26140950 |
| Klinke G et al. | LC-MS/MS based assay and reference intervals in children and adolescents for oxysterols elevated in Niemann-Pick diseases. | 2015 | Clin. Biochem. | pmid:25819840 |
| Son Y et al. | 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25576871 |
| Odermatt A and Klusonova P | 11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25151952 |
| Lee DH et al. | Rotundarpene attenuates cholesterol oxidation product-induced apoptosis by suppressing the mitochondrial pathway and the caspase-8- and bid-dependent pathways. | 2015 | Eur. J. Pharmacol. | pmid:25592323 |
| Zhang H et al. | Diagnosis of Niemann-Pick disease type C with 7-ketocholesterol screening followed by NPC1/NPC2 gene mutation confirmation in Chinese patients. | 2014 | Orphanet J Rare Dis | pmid:24915861 |
| Buttari B et al. | Resveratrol counteracts inflammation in human M1 and M2 macrophages upon challenge with 7-oxo-cholesterol: potential therapeutic implications in atherosclerosis. | 2014 | Oxid Med Cell Longev | pmid:24895526 |