7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yoshida T et al. | Origin of oxysterols in hepatic bile of patients with biliary infection. | 2003 | Am. J. Gastroenterol. | pmid:14572579 |
| Micheletta F et al. | Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14592846 |
| Girão H et al. | Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases. | 2003 | Exp. Cell Res. | pmid:14644170 |
| Diestel A et al. | Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. | 2003 | J. Exp. Med. | pmid:14657223 |
| Gaus K et al. | Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. | 2004 | FASEB J. | pmid:14734645 |
| Wang J et al. | Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): implications for lipid raft structure and function. | 2004 | Biochemistry | pmid:14744146 |
| Tamasawa N and Takebe K | Analytical examination of oxidized free and esterified 7-ketocholesterol and related oxysterols in human plasma incubated with copper. | 1992 | Tohoku J. Exp. Med. | pmid:1488757 |
| Schweizer RA et al. | Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. | 2004 | J. Biol. Chem. | pmid:14973125 |
| Biasi F et al. | Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation. | 2004 | FASEB J. | pmid:14977888 |
| Millanvoye-Van Brussel E et al. | Lysophosphatidylcholine and 7-oxocholesterol modulate Ca2+ signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2. | 2004 | Biochem. J. | pmid:14992685 |
| Kahn E et al. | Analysis of the fluorescence of monodansylcadaverine-positive cytoplasmic structures during 7-ketocholesterol-induced cell death. | 2004 | Anal. Quant. Cytol. Histol. | pmid:15032081 |
| Leonarduzzi G et al. | Trojan horse-like behavior of a biologically representative mixture of oxysterols. | 2004 Feb-Apr | Mol. Aspects Med. | pmid:15051324 |
| Hult M et al. | Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. | 2004 | Cell. Mol. Life Sci. | pmid:15095019 |
| Berthier A et al. | Involvement of a calcium-dependent dephosphorylation of BAD associated with the localization of Trpc-1 within lipid rafts in 7-ketocholesterol-induced THP-1 cell apoptosis. | 2004 | Cell Death Differ. | pmid:15105836 |
| Dorset DL | Binary phase behavior of angiotoxic oxidized cholesterols with cholesterol. | 1992 | Biochim. Biophys. Acta | pmid:1511006 |
| Gregorio-King CC et al. | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15120425 |
| Akiba S et al. | The leaf extract of Ginkgo Biloba L. suppresses oxidized LDL-stimulated fibronectin production through an antioxidant action in rat mesangial cells. | 2004 | Br. J. Pharmacol. | pmid:15148252 |
| Frick C et al. | Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase. | 2004 | J. Biol. Chem. | pmid:15152005 |
| Gouédard C et al. | Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. | 2004 | Mol. Cell. Biol. | pmid:15169886 |
| Rodriguez IR et al. | Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol. | 2004 | Invest. Ophthalmol. Vis. Sci. | pmid:15277510 |
| Seye CI et al. | 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling. | 2004 | Cardiovasc. Res. | pmid:15364622 |
| Scopesi F et al. | Cholesterol oxidation in intravenous lipid emulsions: safety of preparations before and after experimental hyperoxia. | 2004 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:15449575 |
| Martinet W et al. | 7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15458974 |
| Gouédard C et al. | Induction of the paraoxonase-1 gene expression by resveratrol. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15458977 |
| Akiba S et al. | Translocation of phospholipase A2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester formation. | 2004 | Biochim. Biophys. Acta | pmid:15522824 |
| Leoni V et al. | Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis. | 2005 | J. Lipid Res. | pmid:15576852 |
| Huang RF et al. | In vitro folate supplementation alleviates oxidative stress, mitochondria-associated death signalling and apoptosis induced by 7-ketocholesterol. | 2004 | Br. J. Nutr. | pmid:15613250 |
| Rimner A et al. | Relevance and mechanism of oxysterol stereospecifity in coronary artery disease. | 2005 | Free Radic. Biol. Med. | pmid:15649656 |
| Brown BE et al. | Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells. | 2005 | Diabetologia | pmid:15660260 |
| Kahn E et al. | FRET multiphoton spectral imaging microscopy of 7-ketocholesterol and Nile Red in U937 monocytic cells loaded with 7-ketocholesterol. | 2004 | Anal. Quant. Cytol. Histol. | pmid:15678612 |
| Shimozawa M et al. | The inhibitory effect of alacepril, an angiotensin-converting enzyme inhibitor, on endothelial inflammatory response induced by oxysterol and TNF-alpha. | 2004 | Redox Rep. | pmid:15720832 |
| Shimozawa M et al. | 7-Ketocholesterol enhances the expression of adhesion molecules on human aortic endothelial cells by increasing the production of reactive oxygen species. | 2004 | Redox Rep. | pmid:15720835 |
| Cheng YW et al. | Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. | 2005 | Food Chem. Toxicol. | pmid:15721210 |
| Vejux A et al. | 7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionation. | 2005 | Cytometry A | pmid:15739183 |
| Zhang Q et al. | [Quantitative determination of 7-ketocholesterol in human fetal liver cell supernatant and lysate by high performance liquid chromatography]. | 1997 | Se Pu | pmid:15739446 |
| Yoshioka N et al. | Oxysterols increase in diabetic rats. | 2005 | Free Radic. Res. | pmid:15788234 |
| Rosa A et al. | Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues. | 2005 | Toxicol. Lett. | pmid:15795088 |
| Jessup W and Brown AJ | Novel routes for metabolism of 7-ketocholesterol. | 2005 | Rejuvenation Res | pmid:15798369 |
| Raith K et al. | A new LC/APCI-MS method for the determination of cholesterol oxidation products in food. | 2005 | J Chromatogr A | pmid:15844526 |
| Boaz M et al. | Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort. | 2005 | Nephron Clin Pract | pmid:15849477 |
| Sahai E et al. | Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. | 2005 | BMC Biotechnol. | pmid:15910685 |
| Miyashita Y et al. | Apoptosis induced by 7-ketocholesterol is enhanced in smooth muscle cells derived from OLETF rats. | 2005 | J. Atheroscler. Thromb. | pmid:15942119 |
| Berthier A et al. | 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways. | 2005 | FEBS J. | pmid:15955068 |
| Lee HS et al. | TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15993097 |
| Freeman NE et al. | Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages. | 2005 | J. Lipid Res. | pmid:15995174 |
| Kasperczyk S et al. | Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead. | 2005 | Hum Exp Toxicol | pmid:16004195 |
| Massey JB and Pownall HJ | The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I. | 2005 | Biochemistry | pmid:16042420 |
| Napolitano M and Bravo E | Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. | 2005 | Eur. J. Clin. Invest. | pmid:16101668 |
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |
| Rho MC et al. | 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death. | 2005 | J. Mol. Cell. Cardiol. | pmid:16198370 |