7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tomasik A et al. | Impact of baseline level of 7-ketocholesterol on the rate of coronary reintervention in coronary artery disease patients--results of an observational study with questionnaire-based follow up. | 2000 Jul-Aug | Med. Sci. Monit. | pmid:11208404 |
| Echarte M et al. | Oxidation process affecting fatty acids and cholesterol in fried and roasted salmon. | 2001 | J. Agric. Food Chem. | pmid:11714374 |
| Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
| Iuliano L et al. | Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11597949 |
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Lee JI et al. | Formation of cholesterol oxides in irradiated raw and cooked chicken meat during storage. | 2001 | Poult. Sci. | pmid:11214329 |
| Englund MC et al. | 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages. | 2001 | Atherosclerosis | pmid:11500175 |
| Tamasawa N et al. | An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture. | 2001 | Biochim. Biophys. Acta | pmid:11325610 |
| Lyons MA and Brown AJ | 7-Ketocholesterol delivered to mice in chylomicron remnant-like particles is rapidly metabolised, excreted and does not accumulate in aorta. | 2001 | Biochim. Biophys. Acta | pmid:11239823 |
| Dulak J et al. | Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation. | 2001 | Atherosclerosis | pmid:11730812 |
| Sleer LS et al. | Interaction of caveolin with 7-ketocholesterol. | 2001 | Atherosclerosis | pmid:11689206 |
| Skrzep-Poloczek B et al. | Nephrotic origin hyperlipidemia, relative reduction of vitamin E level and subsequent oxidative stress may promote atherosclerosis. | 2001 | Nephron | pmid:11528235 |
| Phillips JE et al. | 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells. | 2001 | Atherosclerosis | pmid:11689214 |
| Mahfouz M and Kummerow F | Oxidized low density lipoprotein inhibits prostacyclin generation by rat aorta in vitro: a key role of lysolecithin. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785781 |
| Lyons MA and Brown AJ | Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells. | 2001 | Lipids | pmid:11521968 |
| Han J et al. | Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I. | 2001 | J. Biol. Chem. | pmid:11278882 |
| Burnett JR et al. | Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. | 2001 | Clin. Chim. Acta | pmid:11282095 |
| Gaus K et al. | A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1. | 2001 | Biochemistry | pmid:11478905 |
| Savouret JF et al. | 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor. | 2001 | J. Biol. Chem. | pmid:11042205 |
| Miyajima H et al. | Increased oxysterols associated with iron accumulation in the brains and visceral organs of acaeruloplasminaemia patients. | 2001 | QJM | pmid:11493718 |
| Kimura T et al. | Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | 2001 | J. Biol. Chem. | pmid:11427538 |
| Thomas SR et al. | Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11304477 |
| Moreira EF et al. | Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. | 2001 | J. Biol. Chem. | pmid:11278871 |
| Hamilton JA et al. | Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL. | 2001 | Biochem. J. | pmid:11256965 |
| Gaus K et al. | Inhibition of cholesterol efflux by 7-ketocholesterol: comparison between cells, plasma membrane vesicles, and liposomes as cholesterol donors. | 2001 | Biochemistry | pmid:11669638 |
| Nam KC et al. | Cholesterol oxidation products in irradiated raw meat with different packaging and storage time. | 2001 | Meat Sci. | pmid:22062435 |
| Ahn DU et al. | Effect of irradiation and packaging conditions after cooking on the formation of cholesterol and lipid oxidation products in meats during storage. | 2001 | Meat Sci. | pmid:22061714 |
| Song C et al. | Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis. | 2001 | Steroids | pmid:11182136 |
| Smondyrev AM and Berkowitz ML | Effects of oxygenated sterol on phospholipid bilayer properties: a molecular dynamics simulation. | 2001 | Chem. Phys. Lipids | pmid:11518570 |
| Jessup W et al. | Oxidized lipoproteins and macrophages. | 2002 | Vascul. Pharmacol. | pmid:12449020 |
| Oyama T et al. | Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells. | 2002 | J. Atheroscler. Thromb. | pmid:12236314 |
| Miyashita Y et al. | Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. | 2002 | J. Atheroscler. Thromb. | pmid:12238640 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Baggio SR et al. | Cholesterol oxides, cholesterol, total lipid, and fatty acid composition in turkey meat. | 2002 | J. Agric. Food Chem. | pmid:12358469 |
| Kim JW et al. | Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. | 2002 | Exp. Mol. Med. | pmid:12085989 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |
| Kahn E et al. | Flow cytometry and factor analysis evaluation of confocal image sequences of morphologic and functional changes occurring at the mitochondrial level during 7-ketocholesterol-induced cell death. | 2002 | Anal. Quant. Cytol. Histol. | pmid:12508695 |
| Lyons MA et al. | Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice. | 2002 | Biochim. Biophys. Acta | pmid:12020639 |
| Fujita T et al. | Chronic ethanol feeding increases 7-hydroperoxycholesterol and oxysterols in rat skeletal muscle. | 2002 | Metab. Clin. Exp. | pmid:12037727 |
| Deckert V et al. | Prevention of LDL alpha-tocopherol consumption, cholesterol oxidation, and vascular endothelium dysfunction by polyphenolic compounds from red wine. | 2002 | Atherosclerosis | pmid:12208469 |
| Miguet-Alfonsi C et al. | Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. | 2002 | Biochem. Pharmacol. | pmid:12147305 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| Uemura M et al. | Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. | 2002 | Eur. J. Pharmacol. | pmid:12450566 |
| Maeda Y et al. | A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. | 2002 | Steroids | pmid:12117617 |
| Meynier A et al. | Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters. | 2002 | Br. J. Nutr. | pmid:12010578 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Scopesi F et al. | 7-ketocholesterol in human and adapted milk formulas. | 2002 | Clin Nutr | pmid:12381334 |
| Moriel P et al. | Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension. | 2002 | Braz. J. Med. Biol. Res. | pmid:12426629 |
| Fainaru O et al. | Active labour is associated with increased oxidisibility of serum lipids ex vivo. | 2002 | BJOG | pmid:12197375 |
| Csallany AS et al. | Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions. | 2002 | Int J Food Sci Nutr | pmid:12396465 |