7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alemany L et al. | Relative expression of cholesterol transport-related proteins and inflammation markers through the induction of 7-ketosterol-mediated stress in Caco-2 cells. | 2013 | Food Chem. Toxicol. | pmid:23454145 |
| Amaral J et al. | 7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model. | 2013 | PLoS ONE | pmid:23409131 |
| Tesoriere L et al. | Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress. | 2013 | Br. J. Nutr. | pmid:23228674 |
| Siragusa M and Sessa WC | Telmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and survival. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23702662 |
| He C et al. | 7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B. | 2013 | Am. J. Pathol. | pmid:23770348 |
| Miah S et al. | Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. | 2013 | Exp. Toxicol. Pathol. | pmid:22999639 |
| Sharma A et al. | Effects of hydroquinone on retinal and vascular cells in vitro. | 2012 May-Jun | Indian J Ophthalmol | pmid:22569379 |
| Wang Y et al. | Cyanidin-3-O-β-glucoside induces oxysterol efflux from endothelial cells: role of liver X receptor alpha. | 2012 | Atherosclerosis | pmid:22749359 |
| Alemany L et al. | Evaluation of the cytotoxic effect of 7keto-stigmasterol and 7keto-cholesterol in human intestinal (Caco-2) cells. | 2012 | Food Chem. Toxicol. | pmid:22750387 |
| Yoda T et al. | Thermo-induced vesicular dynamics of membranes containing cholesterol derivatives. | 2012 | Lipids | pmid:22752691 |
| Schrader C et al. | Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. | 2012 | J. Cell. Mol. Med. | pmid:22304296 |
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| Butterfield DA et al. | Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. | 2012 | Int. J. Neuropsychopharmacol. | pmid:21767440 |
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| Pristerà A et al. | Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability. | 2012 | PLoS ONE | pmid:22870192 |
| Lai YL et al. | Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases. | 2012 | J Clin Biochem Nutr | pmid:22247606 |
| Svistounov D et al. | The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells. | 2012 | PLoS ONE | pmid:23029409 |
| Fu D et al. | Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy. | 2012 | Diabetologia | pmid:22935961 |
| Zheng W et al. | Spatial distribution of the pathways of cholesterol homeostasis in human retina. | 2012 | PLoS ONE | pmid:22629470 |
| Xu L et al. | 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. | 2012 | Biochim. Biophys. Acta | pmid:22425966 |
| Corradini SG et al. | Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control. | 2012 | World J. Gastroenterol. | pmid:22408352 |
| RodrÃguez-Carpena JG et al. | Inhibition of cholesterol oxidation products (COPs) formation in emulsified porcine patties by phenolic-rich avocado (Persea americana Mill.) extracts. | 2012 | J. Agric. Food Chem. | pmid:22292505 |
| Chew PY et al. | Does lycopene offer human LDL any protection against myeloperoxidase activity? | 2012 | Mol. Cell. Biochem. | pmid:21987235 |
| Cohen E et al. | Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity. | 2012 | J Lipids | pmid:22690338 |
| Wu M et al. | Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22678501 |
| Islam MO et al. | Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display. | 2012 | Int J Mol Sci | pmid:22606021 |
| Pédeboscq S et al. | Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro. | 2012 | PLoS ONE | pmid:22590613 |
| Farrell GC et al. | NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | 2012 | Gut Liver | pmid:22570745 |
| Harder T | The T Cell Plasma Membrane Lipid Bilayer Stages TCR-proximal Signaling Events. | 2012 | Front Immunol | pmid:22566932 |
| Shentu TP et al. | The role of oxysterols in control of endothelial stiffness. | 2012 | J. Lipid Res. | pmid:22496390 |
| Satchell L and Leake DS | Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis. | 2012 | Biochemistry | pmid:22493939 |
| Cheng AM et al. | Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts. | 2012 | PLoS ONE | pmid:22479476 |
| Gui T et al. | Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. | 2012 | Mediators Inflamm. | pmid:22577254 |
| Ketola K et al. | Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. | 2012 | Br. J. Cancer | pmid:22215106 |
| Katsuyama M et al. | Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. | 2012 | J Clin Biochem Nutr | pmid:22247596 |
| Son Y et al. | Roles of 7-ketocholesterol on the homeostasis of intracellular cholesterol level. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22622234 |
| Steffen Y et al. | Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase. | 2012 | Nitric Oxide | pmid:22766265 |
| Rutherford LD and Gieseg SP | 7-ketocholesterol is not cytotoxic to U937 cells when incorporated into acetylated low density lipoprotein. | 2012 | Lipids | pmid:22124807 |
| Catarino S et al. | Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells. | 2012 | Acta Ophthalmol | pmid:22313893 |
| Li W et al. | Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent. | 2012 | Free Radic. Biol. Med. | pmid:22985798 |
| Arciello M et al. | Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. | 2012 | Dig Liver Dis | pmid:22154950 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Lim L et al. | Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. | 2012 | Cell Death Differ. | pmid:21818119 |
| Huang JD et al. | Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization. | 2012 | Biochim. Biophys. Acta | pmid:22342272 |
| Ostrowska M et al. | Cerebrotendinous xanthomatosis: a rare cause of spinocerebellar syndrome. | 2011 Nov-Dec | Neurol. Neurochir. Pol. | pmid:22212991 |
| Aluf Y et al. | Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule. | 2011 Jul-Aug | Neuropharmacology | pmid:21414328 |
| Menéndez-Carreño M et al. | Correlation between serum content of the main COPs (cholesterol oxidation products) from autoxidation and cardiovascular risk factors. | 2011 Jan-Feb | Nutr Hosp | pmid:21519741 |
| Zhou T et al. | The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. | 2011 | Diabetologia | pmid:20978740 |