7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee CS et al. | Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers. | 2007 | Neurochem. Res. | pmid:17151911 |
| Han JH et al. | Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition. | 2007 | Brain Res. | pmid:17224136 |
| Javitt NB | Oxysterols: functional significance in fetal development and the maintenance of normal retinal function. | 2007 | Curr. Opin. Lipidol. | pmid:17495602 |
| Mazalli MR and Bragagnolo N | Effect of storage on cholesterol oxide formation and fatty acid alterations in egg powder. | 2007 | J. Agric. Food Chem. | pmid:17348676 |
| Ferderbar S et al. | Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. | 2007 | Diabetes Metab. Res. Rev. | pmid:16634125 |
| Vitha MF and Clarke RJ | Comparison of excitation and emission ratiometric fluorescence methods for quantifying the membrane dipole potential. | 2007 | Biochim. Biophys. Acta | pmid:16904627 |
| Arca M et al. | Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy. | 2007 | Free Radic. Biol. Med. | pmid:17291993 |
| Erridge C et al. | 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. | 2007 | Free Radic. Res. | pmid:17364953 |
| Larsson H et al. | In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress. | 2007 | Free Radic. Biol. Med. | pmid:17664133 |
| Saldanha T and Bragagnolo N | Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi). | 2007 | Lipids | pmid:17492472 |
| Piga R et al. | Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants. | 2007 | Neurotoxicology | pmid:16942797 |
| Jiang X et al. | Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17154356 |
| Bravo E and Napolitano M | Mechanisms involved in chylomicron remnant lipid uptake by macrophages. | 2007 | Biochem. Soc. Trans. | pmid:17511627 |
| Sasaki H et al. | Vascular smooth muscle cell apoptosis induced by 7-ketocholesterol was mediated via Ca2+ and inhibited by the calcium channel blocker nifedipine. | 2007 | Metab. Clin. Exp. | pmid:17292724 |
| Wen Y and Leake DS | Low density lipoprotein undergoes oxidation within lysosomes in cells. | 2007 | Circ. Res. | pmid:17446432 |
| Neekhra A et al. | Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17325185 |
| Joffre C et al. | Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. | 2007 | Curr. Eye Res. | pmid:17453947 |
| Terasaka N et al. | High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17846428 |
| Zhou L et al. | Different cytotoxic injuries induced by lysophosphatidylcholine and 7-ketocholesterol in mouse endothelial cells. | 2006 May-Jun | Endothelium | pmid:16840177 |
| Zunin P et al. | Sterol oxidation in meat- and fish-based homogenized baby foods containing vegetable oils. | 2006 Mar-Apr | J AOAC Int | pmid:16640291 |
| Widerak M et al. | The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. | 2006 Mar-Apr | Biochimie | pmid:16480812 |
| Leonarduzzi G et al. | Early involvement of ROS overproduction in apoptosis induced by 7-ketocholesterol. | 2006 Mar-Apr | Antioxid. Redox Signal. | pmid:16677084 |
| Adachi J et al. | Enhanced lipid peroxidation in tourniquet-release mice. | 2006 | Clin. Chim. Acta | pmid:16624265 |
| Staprans I et al. | Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins. | 2006 | J. Lipid Res. | pmid:16894239 |
| Naito Y et al. | Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species. | 2006 | Eur. J. Pharmacol. | pmid:16919261 |
| Luthra S et al. | Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17122150 |
| Ohtsuka M et al. | Lipids deposited in human atheromatous lesions induce apoptosis of human vascular smooth muscle cells. | 2006 | J. Atheroscler. Thromb. | pmid:17146154 |
| Kiss L et al. | Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function. | 2006 | Int. J. Mol. Med. | pmid:17089016 |
| Lee JW et al. | Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina. | 2006 | Exp. Eye Res. | pmid:16549062 |
| Odermatt A et al. | Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1. | 2006 | Mol. Cell. Endocrinol. | pmid:16412558 |
| Kim YJ et al. | 7-Ketocholesterol enhances 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells. | 2006 | J Neural Transm | pmid:16715209 |
| Stanley N et al. | Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions. | 2006 | Free Radic. Biol. Med. | pmid:16632123 |
| Lee HW et al. | Formation of cholesterol oxidation products in marinated foods during heating. | 2006 | J. Agric. Food Chem. | pmid:16787042 |
| Lee CS et al. | Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. | 2006 | Neuroreport | pmid:16407768 |
| Kahn E et al. | Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells. | 2006 | Anal. Quant. Cytol. Histol. | pmid:17220145 |
| Adachi J et al. | Skeletal muscle and liver oxysterols during fasting and alcohol exposure. | 2006 | Metab. Clin. Exp. | pmid:16324930 |
| Steffen Y et al. | Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio. | 2006 | Free Radic. Biol. Med. | pmid:16962939 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Hall MC | The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells. | 2006 | Mol. Cell. Biochem. | pmid:16983501 |
| Nakagawa K et al. | Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. | 2006 | Kobe J Med Sci | pmid:17006054 |
| Maeda Y et al. | Species differences among various rodents in the conversion of 7alpha-hydroxycholesterol in liver microsomes. | 2006 | Steroids | pmid:16455124 |
| Dushkin MI et al. | Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | 2006 | Bull. Exp. Biol. Med. | pmid:16984105 |
| He X et al. | Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. | 2006 | J. Neuropathol. Exp. Neurol. | pmid:16825952 |
| Jessup W and Brown AJ | Novel routes for metabolism of 7-ketocholesterol. | 2005 | Rejuvenation Res | pmid:15798369 |
| Lee HS et al. | TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15993097 |
| Freeman NE et al. | Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages. | 2005 | J. Lipid Res. | pmid:15995174 |
| Berthier A et al. | 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways. | 2005 | FEBS J. | pmid:15955068 |
| Kasperczyk S et al. | Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead. | 2005 | Hum Exp Toxicol | pmid:16004195 |
| Miyashita Y et al. | Apoptosis induced by 7-ketocholesterol is enhanced in smooth muscle cells derived from OLETF rats. | 2005 | J. Atheroscler. Thromb. | pmid:15942119 |
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |
| Raith K et al. | A new LC/APCI-MS method for the determination of cholesterol oxidation products in food. | 2005 | J Chromatogr A | pmid:15844526 |
| Rimner A et al. | Relevance and mechanism of oxysterol stereospecifity in coronary artery disease. | 2005 | Free Radic. Biol. Med. | pmid:15649656 |
| Rosa A et al. | Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues. | 2005 | Toxicol. Lett. | pmid:15795088 |
| Rho MC et al. | 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death. | 2005 | J. Mol. Cell. Cardiol. | pmid:16198370 |
| Vejux A et al. | 7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionation. | 2005 | Cytometry A | pmid:15739183 |
| Massey JB and Pownall HJ | The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I. | 2005 | Biochemistry | pmid:16042420 |
| Yoshioka N et al. | Oxysterols increase in diabetic rats. | 2005 | Free Radic. Res. | pmid:15788234 |
| Sahai E et al. | Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. | 2005 | BMC Biotechnol. | pmid:15910685 |
| Prunet C et al. | Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study. | 2005 | J. Biochem. Mol. Toxicol. | pmid:16292754 |
| Corradini SG et al. | High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. | 2005 | Liver Transpl. | pmid:16258953 |
| Boaz M et al. | Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort. | 2005 | Nephron Clin Pract | pmid:15849477 |
| Leoni V et al. | Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis. | 2005 | J. Lipid Res. | pmid:15576852 |
| Kinumi T et al. | Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL. | 2005 | Free Radic. Res. | pmid:16298863 |
| Cheng YW et al. | Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. | 2005 | Food Chem. Toxicol. | pmid:15721210 |
| Brown BE et al. | Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells. | 2005 | Diabetologia | pmid:15660260 |
| Napolitano M and Bravo E | Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. | 2005 | Eur. J. Clin. Invest. | pmid:16101668 |
| Suh MH et al. | Antioxidative activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats. | 2005 | J. Agric. Food Chem. | pmid:16332125 |
| Ozaki H et al. | Enhancement of MMP-9 activity in THP-1 cells by 7-ketocholesterol and its suppression by the HMG-CoA reductase inhibitor fluvastatin. | 2005 | J. Atheroscler. Thromb. | pmid:16394614 |
| Rosa A et al. | Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA. | 2005 | Free Radic. Res. | pmid:16298741 |
| Scopesi F et al. | Cholesterol oxidation in intravenous lipid emulsions: safety of preparations before and after experimental hyperoxia. | 2004 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:15449575 |
| Leonarduzzi G et al. | Trojan horse-like behavior of a biologically representative mixture of oxysterols. | 2004 Feb-Apr | Mol. Aspects Med. | pmid:15051324 |
| Gouédard C et al. | Induction of the paraoxonase-1 gene expression by resveratrol. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15458977 |
| Gouédard C et al. | Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. | 2004 | Mol. Cell. Biol. | pmid:15169886 |
| Micheletta F et al. | Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14592846 |
| Kahn E et al. | FRET multiphoton spectral imaging microscopy of 7-ketocholesterol and Nile Red in U937 monocytic cells loaded with 7-ketocholesterol. | 2004 | Anal. Quant. Cytol. Histol. | pmid:15678612 |
| Rusiñol AE et al. | AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis. | 2004 | J. Biol. Chem. | pmid:14559920 |
| Wang J et al. | Relationship between sterol/steroid structure and participation in ordered lipid domains (lipid rafts): implications for lipid raft structure and function. | 2004 | Biochemistry | pmid:14744146 |
| Kahn E et al. | Analysis of the fluorescence of monodansylcadaverine-positive cytoplasmic structures during 7-ketocholesterol-induced cell death. | 2004 | Anal. Quant. Cytol. Histol. | pmid:15032081 |
| Rodriguez IR et al. | Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol. | 2004 | Invest. Ophthalmol. Vis. Sci. | pmid:15277510 |
| Seye CI et al. | 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling. | 2004 | Cardiovasc. Res. | pmid:15364622 |
| Frick C et al. | Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase. | 2004 | J. Biol. Chem. | pmid:15152005 |
| Berthier A et al. | Involvement of a calcium-dependent dephosphorylation of BAD associated with the localization of Trpc-1 within lipid rafts in 7-ketocholesterol-induced THP-1 cell apoptosis. | 2004 | Cell Death Differ. | pmid:15105836 |
| Gaus K et al. | Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. | 2004 | FASEB J. | pmid:14734645 |
| Biasi F et al. | Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation. | 2004 | FASEB J. | pmid:14977888 |
| Schweizer RA et al. | Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. | 2004 | J. Biol. Chem. | pmid:14973125 |
| Akiba S et al. | The leaf extract of Ginkgo Biloba L. suppresses oxidized LDL-stimulated fibronectin production through an antioxidant action in rat mesangial cells. | 2004 | Br. J. Pharmacol. | pmid:15148252 |
| Gregorio-King CC et al. | Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells. | 2004 | J. Steroid Biochem. Mol. Biol. | pmid:15120425 |
| Akiba S et al. | Translocation of phospholipase A2 to membranes by oxidized LDL and hydroxyoctadecadienoic acid to contribute to cholesteryl ester formation. | 2004 | Biochim. Biophys. Acta | pmid:15522824 |
| Huang RF et al. | In vitro folate supplementation alleviates oxidative stress, mitochondria-associated death signalling and apoptosis induced by 7-ketocholesterol. | 2004 | Br. J. Nutr. | pmid:15613250 |
| Hult M et al. | Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. | 2004 | Cell. Mol. Life Sci. | pmid:15095019 |
| Millanvoye-Van Brussel E et al. | Lysophosphatidylcholine and 7-oxocholesterol modulate Ca2+ signals and inhibit the phosphorylation of endothelial NO synthase and cytosolic phospholipase A2. | 2004 | Biochem. J. | pmid:14992685 |
| Martinet W et al. | 7-ketocholesterol induces protein ubiquitination, myelin figure formation, and light chain 3 processing in vascular smooth muscle cells. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15458974 |
| Shimozawa M et al. | The inhibitory effect of alacepril, an angiotensin-converting enzyme inhibitor, on endothelial inflammatory response induced by oxysterol and TNF-alpha. | 2004 | Redox Rep. | pmid:15720832 |
| Shimozawa M et al. | 7-Ketocholesterol enhances the expression of adhesion molecules on human aortic endothelial cells by increasing the production of reactive oxygen species. | 2004 | Redox Rep. | pmid:15720835 |
| Jacheć W et al. | Lipid peroxidation and vitamin E in human coronary atherosclerotic lesions. | 2003 | Clin. Chim. Acta | pmid:12636930 |
| Iuliano L et al. | Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status. | 2003 | Anal. Biochem. | pmid:12531208 |
| Bortolomeazzi R et al. | Presence of phytosterol oxides in crude vegetable oils and their fate during refining. | 2003 | J. Agric. Food Chem. | pmid:12670187 |
| Zahm JM et al. | Chronology of cellular alterations during 7-ketocholesterol-induced cell death on A7R5 rat smooth muscle cells: analysis by time lapse-video microscopy and conventional fluorescence microscopy. | 2003 | Cytometry A | pmid:12655649 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| Ong JM et al. | Oxysterol-induced toxicity in R28 and ARPE-19 cells. | 2003 | Neurochem. Res. | pmid:12718442 |