7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Mariutti LR et al. | Lipid and cholesterol oxidation in chicken meat are inhibited by sage but not by garlic. | 2011 | J. Food Sci. | pmid:22417489 |
| Wyrwoll CS et al. | 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. | 2011 | Front Neuroendocrinol | pmid:21144857 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Flück CE et al. | Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia. | 2011 | PLoS ONE | pmid:21647419 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Heo GY et al. | Conversion of 7-ketocholesterol to oxysterol metabolites by recombinant CYP27A1 and retinal pigment epithelial cells. | 2011 | J. Lipid Res. | pmid:21411718 |
| Kahn E et al. | Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis. | 2011 | Cytometry A | pmid:21381190 |
| Jiang X et al. | A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma. | 2011 | J. Lipid Res. | pmid:21518695 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Ragot K et al. | α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes. | 2011 | Chem. Phys. Lipids | pmid:21575614 |
| Itabe H et al. | The Dynamics of Oxidized LDL during Atherogenesis. | 2011 | J Lipids | pmid:21660303 |
| VÃlchez C et al. | Marine carotenoids: biological functions and commercial applications. | 2011 | Mar Drugs | pmid:21556162 |
| Charvet C et al. | Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1. | 2011 | J. Biol. Chem. | pmid:21498512 |
| Coomes E et al. | Methotrexate in atherogenesis and cholesterol metabolism. | 2011 | Cholesterol | pmid:21490773 |
| Menu P et al. | Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome. | 2011 | Cell Death Dis | pmid:21451572 |
| Niki E | Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited. | 2011 | J Clin Biochem Nutr | pmid:21297905 |
| Vestergaard MC et al. | The effect of oxycholesterols on thermo-induced membrane dynamics. | 2011 | Biochim. Biophys. Acta | pmid:21600872 |
| Zocche Soprana H et al. | Cellular prion protein (PrP(C)) and superoxide dismutase (SOD) in vascular cells under oxidative stress. | 2011 | Exp. Toxicol. Pathol. | pmid:20060694 |
| Villard PH et al. | CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site. | 2011 | PLoS ONE | pmid:21304969 |
| Zhou T et al. | The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. | 2011 | Diabetologia | pmid:20978740 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Menéndez-Carreño M et al. | Correlation between serum content of the main COPs (cholesterol oxidation products) from autoxidation and cardiovascular risk factors. | 2011 Jan-Feb | Nutr Hosp | pmid:21519741 |
| Aluf Y et al. | Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule. | 2011 Jul-Aug | Neuropharmacology | pmid:21414328 |
| Ostrowska M et al. | Cerebrotendinous xanthomatosis: a rare cause of spinocerebellar syndrome. | 2011 Nov-Dec | Neurol. Neurochir. Pol. | pmid:22212991 |
| Wang Y et al. | Cyanidin-3-O-β-glucoside induces oxysterol efflux from endothelial cells: role of liver X receptor alpha. | 2012 | Atherosclerosis | pmid:22749359 |
| Alemany L et al. | Evaluation of the cytotoxic effect of 7keto-stigmasterol and 7keto-cholesterol in human intestinal (Caco-2) cells. | 2012 | Food Chem. Toxicol. | pmid:22750387 |
| Yoda T et al. | Thermo-induced vesicular dynamics of membranes containing cholesterol derivatives. | 2012 | Lipids | pmid:22752691 |
| Schrader C et al. | Genistein as a potential inducer of the anti-atherogenic enzyme paraoxonase-1: studies in cultured hepatocytes in vitro and in rat liver in vivo. | 2012 | J. Cell. Mol. Med. | pmid:22304296 |
| Aye IL et al. | Oxysterols exert proinflammatory effects in placental trophoblasts via TLR4-dependent, cholesterol-sensitive activation of NF-κB. | 2012 | Mol. Hum. Reprod. | pmid:22238372 |
| Butterfield DA et al. | Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. | 2012 | Int. J. Neuropsychopharmacol. | pmid:21767440 |
| Olkkonen VM | Macrophage oxysterols and their binding proteins: roles in atherosclerosis. | 2012 | Curr. Opin. Lipidol. | pmid:22814702 |
| Son SH et al. | Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages. | 2012 | PLoS ONE | pmid:22427949 |
| Mathieu JM et al. | Increased resistance to oxysterol cytotoxicity in fibroblasts transfected with a lysosomally targeted Chromobacterium oxidase. | 2012 | Biotechnol. Bioeng. | pmid:22447444 |
| Pristerà A et al. | Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability. | 2012 | PLoS ONE | pmid:22870192 |
| Lai YL et al. | Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases. | 2012 | J Clin Biochem Nutr | pmid:22247606 |
| Svistounov D et al. | The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells. | 2012 | PLoS ONE | pmid:23029409 |
| Fu D et al. | Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy. | 2012 | Diabetologia | pmid:22935961 |
| Zheng W et al. | Spatial distribution of the pathways of cholesterol homeostasis in human retina. | 2012 | PLoS ONE | pmid:22629470 |
| Xu L et al. | 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. | 2012 | Biochim. Biophys. Acta | pmid:22425966 |
| Corradini SG et al. | Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control. | 2012 | World J. Gastroenterol. | pmid:22408352 |
| RodrÃguez-Carpena JG et al. | Inhibition of cholesterol oxidation products (COPs) formation in emulsified porcine patties by phenolic-rich avocado (Persea americana Mill.) extracts. | 2012 | J. Agric. Food Chem. | pmid:22292505 |
| Chew PY et al. | Does lycopene offer human LDL any protection against myeloperoxidase activity? | 2012 | Mol. Cell. Biochem. | pmid:21987235 |
| Cohen E et al. | Increased Levels of Human Carotid Lesion Linoleic Acid Hydroperoxide in Symptomatic and Asymptomatic Patients Is Inversely Correlated with Serum HDL and Paraoxonase 1 Activity. | 2012 | J Lipids | pmid:22690338 |
| Wu M et al. | Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22678501 |
| Islam MO et al. | Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display. | 2012 | Int J Mol Sci | pmid:22606021 |
| Pédeboscq S et al. | Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro. | 2012 | PLoS ONE | pmid:22590613 |
| Farrell GC et al. | NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications. | 2012 | Gut Liver | pmid:22570745 |
| Harder T | The T Cell Plasma Membrane Lipid Bilayer Stages TCR-proximal Signaling Events. | 2012 | Front Immunol | pmid:22566932 |
| Shentu TP et al. | The role of oxysterols in control of endothelial stiffness. | 2012 | J. Lipid Res. | pmid:22496390 |
| Satchell L and Leake DS | Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis. | 2012 | Biochemistry | pmid:22493939 |
| Cheng AM et al. | Apolipoprotein A-I attenuates palmitate-mediated NF-κB activation by reducing Toll-like receptor-4 recruitment into lipid rafts. | 2012 | PLoS ONE | pmid:22479476 |
| Gui T et al. | Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. | 2012 | Mediators Inflamm. | pmid:22577254 |
| Ketola K et al. | Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. | 2012 | Br. J. Cancer | pmid:22215106 |
| Katsuyama M et al. | Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. | 2012 | J Clin Biochem Nutr | pmid:22247596 |
| Son Y et al. | Roles of 7-ketocholesterol on the homeostasis of intracellular cholesterol level. | 2012 | J. Cardiovasc. Pharmacol. | pmid:22622234 |
| Steffen Y et al. | Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase. | 2012 | Nitric Oxide | pmid:22766265 |
| Rutherford LD and Gieseg SP | 7-ketocholesterol is not cytotoxic to U937 cells when incorporated into acetylated low density lipoprotein. | 2012 | Lipids | pmid:22124807 |
| Catarino S et al. | Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells. | 2012 | Acta Ophthalmol | pmid:22313893 |
| Li W et al. | Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent. | 2012 | Free Radic. Biol. Med. | pmid:22985798 |
| Arciello M et al. | Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. | 2012 | Dig Liver Dis | pmid:22154950 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Lim L et al. | Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. | 2012 | Cell Death Differ. | pmid:21818119 |
| Huang JD et al. | Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization. | 2012 | Biochim. Biophys. Acta | pmid:22342272 |
| Sharma A et al. | Effects of hydroquinone on retinal and vascular cells in vitro. | 2012 May-Jun | Indian J Ophthalmol | pmid:22569379 |
| Alemany L et al. | Relative expression of cholesterol transport-related proteins and inflammation markers through the induction of 7-ketosterol-mediated stress in Caco-2 cells. | 2013 | Food Chem. Toxicol. | pmid:23454145 |
| Amaral J et al. | 7-Ketocholesterol induces inflammation and angiogenesis in vivo: a novel rat model. | 2013 | PLoS ONE | pmid:23409131 |
| Appukuttan A et al. | Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase. | 2013 | Cardiovasc. Res. | pmid:23729662 |
| Chalubinski M et al. | The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers. | 2013 | Inflamm. Res. | pmid:24077843 |
| Tesoriere L et al. | Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress. | 2013 | Br. J. Nutr. | pmid:23228674 |
| Siragusa M and Sessa WC | Telmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and survival. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23702662 |
| He C et al. | 7-Ketocholesterol induces autophagy in vascular smooth muscle cells through Nox4 and Atg4B. | 2013 | Am. J. Pathol. | pmid:23770348 |
| Yue Q et al. | 7-ketocholesterol-induced caspase-mediated apoptosis in Saccharomyces cerevisiae. | 2013 | FEMS Yeast Res. | pmid:24028627 |
| Dasari B et al. | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. | 2013 | Curr. Eye Res. | pmid:23841471 |
| Xu M et al. | Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. | 2013 | Biochim. Biophys. Acta | pmid:24095928 |
| Wang SF et al. | 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. | 2013 | Biochem. Pharmacol. | pmid:23792120 |
| Buttari B et al. | 7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages. | 2013 | Biochem. Pharmacol. | pmid:23611834 |
| GarcÃa RA et al. | 11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoEâ»/â» mice. | 2013 | PLoS ONE | pmid:23383297 |
| Wong D and Wang M | Inhibitory activities of some vitamins on the formation of cholesterol oxidation products in beef patties. | 2013 | J. Agric. Food Chem. | pmid:23937446 |
| Okabe A et al. | Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. | 2013 | Redox Biol | pmid:24371802 |
| Chung ML et al. | Profiling of oxidized lipid products of marine fish under acute oxidative stress. | 2013 | Food Chem. Toxicol. | pmid:23220612 |
| Daniil G et al. | Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux. | 2013 | PLoS ONE | pmid:23826352 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol. | 2013 | Biochimie | pmid:22940536 |
| Miah S et al. | Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. | 2013 | Exp. Toxicol. Pathol. | pmid:22999639 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. | 2013 | Biochem. Pharmacol. | pmid:23415904 |
| Ragot K et al. | Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23473804 |
| Loke SY et al. | Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. | 2013 | J. Neurochem. | pmid:23294445 |
| Yamagata K et al. | Epigallocatechin 3-gallate inhibits 7-ketocholesterol-induced monocyte-endothelial cell adhesion. | 2013 | Microvasc. Res. | pmid:23567873 |
| Helmschrodt C et al. | Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. | 2013 | Clin. Chim. Acta | pmid:23827692 |
| Dorantowicz R et al. | [The effect of 7-ketocholesterol on surface ICAM-1 and PECAM-1 expression in human aortic endothelial cells]. | 2014 | Pol. Merkur. Lekarski | pmid:24868894 |
| Zong Y et al. | Toxicity of 7-ketocholesterol on lethality, growth, reproduction, and germline apoptosis in the nematode Caenorhabditis elegans. | 2014 | J. Toxicol. Environ. Health Part A | pmid:24786678 |
| Levy D et al. | Short-term effects of 7-ketocholesterol on human adipose tissue mesenchymal stem cells in vitro. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24491549 |
| Huang JD et al. | 7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo. | 2014 | PLoS ONE | pmid:25036103 |
| Adiguzel Z et al. | Evaluation of apoptotic molecular pathways for smooth muscle cells isolated from thoracic aortic aneurysms in response to oxidized sterols. | 2014 | Mol. Biol. Rep. | pmid:25266234 |
| Rodriguez IR et al. | 7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen. | 2014 | Exp. Eye Res. | pmid:25261634 |
| Tesoriere L et al. | Oxysterol mixture in hypercholesterolemia-relevant proportion causes oxidative stress-dependent eryptosis. | 2014 | Cell. Physiol. Biochem. | pmid:25228229 |
| Rao X et al. | CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. | 2014 | Circ. Res. | pmid:25186795 |
| Tempel W et al. | Structural characterization of human cholesterol 7α-hydroxylase. | 2014 | J. Lipid Res. | pmid:24927729 |
| Phan HT et al. | Localization of amyloid beta (Aβ1-42) protofibrils in membrane lateral compartments: effect of cholesterol and 7-Ketocholesterol. | 2014 | FEBS Lett. | pmid:25131929 |
| Boenzi S et al. | A new simple and rapid LC-ESI-MS/MS method for quantification of plasma oxysterols as dimethylaminobutyrate esters. Its successful use for the diagnosis of Niemann-Pick type C disease. | 2014 | Clin. Chim. Acta | pmid:25038260 |