7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jacheć W et al. | Lipid peroxidation and vitamin E in human coronary atherosclerotic lesions. | 2003 | Clin. Chim. Acta | pmid:12636930 |
| Iuliano L et al. | Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status. | 2003 | Anal. Biochem. | pmid:12531208 |
| Tuomainen TP et al. | Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. | 2003 | Free Radic. Biol. Med. | pmid:14556856 |
| Diestel A et al. | Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. | 2003 | J. Exp. Med. | pmid:14657223 |
| Bortolomeazzi R et al. | Presence of phytosterol oxides in crude vegetable oils and their fate during refining. | 2003 | J. Agric. Food Chem. | pmid:12670187 |
| Monier S et al. | Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12670484 |
| Rosenblat M et al. | Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12615656 |
| Ong JM et al. | Oxysterol-induced toxicity in R28 and ARPE-19 cells. | 2003 | Neurochem. Res. | pmid:12718442 |
| Adachi J et al. | 7-hydroperoxycholesterol and oxysterols as indices of oxidative stress: chronic ethanol feeding and rat skeletal muscle. | 2003 | Leg Med (Tokyo) | pmid:12935564 |
| Girão H et al. | 7-ketocholesterol stimulates differentiation of lens epithelial cells. | 2003 | Mol. Vis. | pmid:14551533 |
| Geng YJ et al. | Cholesterol crystallization and macrophage apoptosis: implication for atherosclerotic plaque instability and rupture. | 2003 | Biochem. Pharmacol. | pmid:14555225 |
| McKeague AL et al. | Staurosporine-induced apoptosis and hydrogen peroxide-induced necrosis in two human breast cell lines. | 2003 | Br. J. Cancer | pmid:12556971 |
| Adachi J et al. | Consecutive administration of paraquat to rats induces enhanced cholesterol peroxidation and lung injury. | 2003 | Arch. Toxicol. | pmid:12799775 |
| Zhang Y et al. | Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1. | 2003 | J. Biol. Chem. | pmid:12533546 |
| Ong WY et al. | Increase in cholesterol and cholesterol oxidation products, and role of cholesterol oxidation products in kainate-induced neuronal injury. | 2003 | Brain Pathol. | pmid:12946016 |
| Akiba S et al. | Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL. | 2003 | Biochem. Biophys. Res. Commun. | pmid:14521937 |
| Petrón MJ et al. | Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams. | 2003 | J. Agric. Food Chem. | pmid:12952434 |
| Jessup W et al. | Oxidized lipoproteins and macrophages. | 2002 | Vascul. Pharmacol. | pmid:12449020 |
| Oyama T et al. | Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells. | 2002 | J. Atheroscler. Thromb. | pmid:12236314 |
| Miyashita Y et al. | Oxysterol-induced apoptosis of vascular smooth muscle cells is reduced by HMG-CoA reductase inhibitor, pravastatin. | 2002 | J. Atheroscler. Thromb. | pmid:12238640 |
| Hayden JM et al. | Induction of monocyte differentiation and foam cell formation in vitro by 7-ketocholesterol. | 2002 | J. Lipid Res. | pmid:11792719 |
| Baggio SR et al. | Cholesterol oxides, cholesterol, total lipid, and fatty acid composition in turkey meat. | 2002 | J. Agric. Food Chem. | pmid:12358469 |
| Kim JW et al. | Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro. | 2002 | Exp. Mol. Med. | pmid:12085989 |
| Tomoyori H et al. | Lymphatic transport of dietary cholesterol oxidation products, cholesterol and triacylglycerols in rats. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036056 |
| Kahn E et al. | Flow cytometry and factor analysis evaluation of confocal image sequences of morphologic and functional changes occurring at the mitochondrial level during 7-ketocholesterol-induced cell death. | 2002 | Anal. Quant. Cytol. Histol. | pmid:12508695 |
| Lyons MA et al. | Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice. | 2002 | Biochim. Biophys. Acta | pmid:12020639 |
| Zwirska-Korczala K et al. | [Assessment of plasma lipid profile oxysterols and vitamin E concentration in morbidity obese patients with coexisting arterial hypertension and non-insulin dependent diabetes mellitus]. | 2002 | Pol. Arch. Med. Wewn. | pmid:12107969 |
| Ghelli A et al. | 7-Ketocholesterol and staurosporine induce opposite changes in intracellular pH, associated with distinct types of cell death in ECV304 cells. | 2002 | Arch. Biochem. Biophys. | pmid:12051665 |
| Deckert V et al. | The impairment of endothelium-dependent arterial relaxation by 7-ketocholesterol is associated with an early activation of protein kinase C. | 2002 | Br. J. Pharmacol. | pmid:12381679 |
| Liu Q et al. | Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for beta(2)-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages. | 2002 | J. Lipid Res. | pmid:12235181 |
| Fujita T et al. | Chronic ethanol feeding increases 7-hydroperoxycholesterol and oxysterols in rat skeletal muscle. | 2002 | Metab. Clin. Exp. | pmid:12037727 |
| Deckert V et al. | Prevention of LDL alpha-tocopherol consumption, cholesterol oxidation, and vascular endothelium dysfunction by polyphenolic compounds from red wine. | 2002 | Atherosclerosis | pmid:12208469 |
| Miguet-Alfonsi C et al. | Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. | 2002 | Biochem. Pharmacol. | pmid:12147305 |
| Gregorio-King CC et al. | Effect of oxysterols on hematopoietic progenitor cells. | 2002 | Exp. Hematol. | pmid:12135663 |
| Uemura M et al. | Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation. | 2002 | Eur. J. Pharmacol. | pmid:12450566 |
| Maeda Y et al. | A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. | 2002 | Steroids | pmid:12117617 |
| Meynier A et al. | Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters. | 2002 | Br. J. Nutr. | pmid:12010578 |
| Ando M et al. | Dietary cholesterol-oxidation products accumulate in serum and liver in apolipoprotein E-deficient mice, but do not accelerate atherosclerosis. | 2002 | Br. J. Nutr. | pmid:12323083 |
| Scopesi F et al. | 7-ketocholesterol in human and adapted milk formulas. | 2002 | Clin Nutr | pmid:12381334 |
| Moriel P et al. | Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension. | 2002 | Braz. J. Med. Biol. Res. | pmid:12426629 |
| Fainaru O et al. | Active labour is associated with increased oxidisibility of serum lipids ex vivo. | 2002 | BJOG | pmid:12197375 |
| Csallany AS et al. | Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions. | 2002 | Int J Food Sci Nutr | pmid:12396465 |
| Echarte M et al. | Oxidation process affecting fatty acids and cholesterol in fried and roasted salmon. | 2001 | J. Agric. Food Chem. | pmid:11714374 |
| Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
| Iuliano L et al. | Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11597949 |
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Lee JI et al. | Formation of cholesterol oxides in irradiated raw and cooked chicken meat during storage. | 2001 | Poult. Sci. | pmid:11214329 |
| Englund MC et al. | 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages. | 2001 | Atherosclerosis | pmid:11500175 |
| Tamasawa N et al. | An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture. | 2001 | Biochim. Biophys. Acta | pmid:11325610 |
| Lyons MA and Brown AJ | 7-Ketocholesterol delivered to mice in chylomicron remnant-like particles is rapidly metabolised, excreted and does not accumulate in aorta. | 2001 | Biochim. Biophys. Acta | pmid:11239823 |
| Dulak J et al. | Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation. | 2001 | Atherosclerosis | pmid:11730812 |
| Sleer LS et al. | Interaction of caveolin with 7-ketocholesterol. | 2001 | Atherosclerosis | pmid:11689206 |
| Skrzep-Poloczek B et al. | Nephrotic origin hyperlipidemia, relative reduction of vitamin E level and subsequent oxidative stress may promote atherosclerosis. | 2001 | Nephron | pmid:11528235 |
| Phillips JE et al. | 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells. | 2001 | Atherosclerosis | pmid:11689214 |
| Mahfouz M and Kummerow F | Oxidized low density lipoprotein inhibits prostacyclin generation by rat aorta in vitro: a key role of lysolecithin. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785781 |
| Lyons MA and Brown AJ | Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells. | 2001 | Lipids | pmid:11521968 |
| Han J et al. | Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I. | 2001 | J. Biol. Chem. | pmid:11278882 |
| Burnett JR et al. | Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. | 2001 | Clin. Chim. Acta | pmid:11282095 |
| Gaus K et al. | A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1. | 2001 | Biochemistry | pmid:11478905 |
| Savouret JF et al. | 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor. | 2001 | J. Biol. Chem. | pmid:11042205 |
| Miyajima H et al. | Increased oxysterols associated with iron accumulation in the brains and visceral organs of acaeruloplasminaemia patients. | 2001 | QJM | pmid:11493718 |
| Kimura T et al. | Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | 2001 | J. Biol. Chem. | pmid:11427538 |
| Thomas SR et al. | Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11304477 |
| Moreira EF et al. | Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. | 2001 | J. Biol. Chem. | pmid:11278871 |
| Hamilton JA et al. | Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL. | 2001 | Biochem. J. | pmid:11256965 |
| Gaus K et al. | Inhibition of cholesterol efflux by 7-ketocholesterol: comparison between cells, plasma membrane vesicles, and liposomes as cholesterol donors. | 2001 | Biochemistry | pmid:11669638 |
| Nam KC et al. | Cholesterol oxidation products in irradiated raw meat with different packaging and storage time. | 2001 | Meat Sci. | pmid:22062435 |
| Ahn DU et al. | Effect of irradiation and packaging conditions after cooking on the formation of cholesterol and lipid oxidation products in meats during storage. | 2001 | Meat Sci. | pmid:22061714 |
| Song C et al. | Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis. | 2001 | Steroids | pmid:11182136 |
| Smondyrev AM and Berkowitz ML | Effects of oxygenated sterol on phospholipid bilayer properties: a molecular dynamics simulation. | 2001 | Chem. Phys. Lipids | pmid:11518570 |
| Tomasik A et al. | Impact of baseline level of 7-ketocholesterol on the rate of coronary reintervention in coronary artery disease patients--results of an observational study with questionnaire-based follow up. | 2000 Jul-Aug | Med. Sci. Monit. | pmid:11208404 |
| Norlin M et al. | 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | 2000 | J. Lipid Res. | pmid:11013305 |
| Brown AJ et al. | Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. | 2000 | J. Lipid Res. | pmid:10681406 |
| Bourdon E et al. | Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116066 |
| Lizard G et al. | Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. | 2000 | Free Radic. Biol. Med. | pmid:10754270 |
| Abo K et al. | Comparative analysis of plasma and erythrocyte 7-ketocholesterol as a marker for oxidative stress in patients with diabetes mellitus. | 2000 | Clin. Biochem. | pmid:11124339 |
| Perségol L et al. | Co-incubation of native and oxidized low-density lipoproteins: potentiation of relaxation impairment. | 2000 | Eur. J. Pharmacol. | pmid:11040350 |
| Liao HS et al. | Expression of class A scavenger receptor inhibits apoptosis of macrophages triggered by oxidized low density lipoprotein and oxysterol. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10938019 |
| Brown AJ et al. | Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. | 2000 | J. Biol. Chem. | pmid:10869358 |
| Yoshida T et al. | Cholestan-3beta,5alpha,6beta-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cells. | 2000 | FEBS Lett. | pmid:10922480 |
| Tsuzuki D et al. | Analysis of 7-ketocholesterol in low density lipoprotein and fatty acid composition in erythrocyte membranes of patients on maintenance hemodialysis and healthy controls. | 2000 | Clin. Chim. Acta | pmid:10767401 |
| Lyons MA and Brown AJ | 7-Ketocholesterol. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224662 |
| Myers SJ and Stanley KK | Src family kinase activation in glycosphingolipid-rich membrane domains of endothelial cells treated with oxidised low density lipoprotein. | 1999 | Atherosclerosis | pmid:10217369 |
| van Reyk DM et al. | Prooxidant and antioxidant activities of macrophages in metal-mediated LDL oxidation: the importance of metal sequestration. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195944 |
| Zarev S et al. | Major differences in oxysterol formation in human low density lipoproteins (LDLs) oxidized by *OH/O2*- free radicals or by copper. | 1999 | FEBS Lett. | pmid:10371147 |
| Gelissen IC et al. | Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid. | 1999 | J. Lipid Res. | pmid:10484610 |
| Urano Y et al. | Vascular smooth muscle cell outgrowth, proliferation, and apoptosis in young and old rats. | 1999 | Atherosclerosis | pmid:10487492 |
| Lizard G et al. | Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10323769 |
| Pirillo A et al. | Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells. | 1999 | FEBS Lett. | pmid:10580102 |
| Inouye M et al. | Glycated hemoglobin and lipid peroxidation in erythrocytes of diabetic patients. | 1999 | Metab. Clin. Exp. | pmid:10024083 |
| Rao ML et al. | Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672272 |
| Lyons MA et al. | Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols. | 1999 | J. Lipid Res. | pmid:10508204 |
| Hakamata H et al. | Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein. | 1998 | J. Lipid Res. | pmid:9548582 |
| Cantwell H and Devery R | The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox. | 1998 | Cell Biol. Toxicol. | pmid:9879932 |
| Dushkin M et al. | Effects of oxysterols upon macrophage and lymphocyte functions in vitro. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9644113 |
| Hakamata H et al. | Cytotoxic effect of oxidized low density lipoprotein on macrophages. | 1998 | J. Atheroscler. Thromb. | pmid:10855560 |
| Pinchuk I et al. | Kinetic analysis of copper-induced peroxidation of LDL. | 1998 | Biochim. Biophys. Acta | pmid:9461257 |
| Hwee Ming Cheng and Kalyana Sundram | Cholesterol oxides and natural autoantibodies. | 1998 | Atherosclerosis | pmid:9862183 |
| Linseisen J and Wolfram G | Absorption of cholesterol oxidation products from ordinary foodstuff in humans. | 1998 | Ann. Nutr. Metab. | pmid:9745108 |
| Deckert V et al. | Inhibition by cholesterol oxides of NO release from human vascular endothelial cells. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9672065 |