7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lin N et al. | Determination of 7-ketocholesterol in plasma by LC-MS for rapid diagnosis of acid SMase-deficient Niemann-Pick disease. | 2014 | J. Lipid Res. | pmid:24190732 |
| Zhang Y et al. | Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 gene. | 2014 | Cardiovasc. Res. | pmid:24445604 |
| Appukuttan A et al. | Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase. | 2013 | Cardiovasc. Res. | pmid:23729662 |
| Chalubinski M et al. | The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers. | 2013 | Inflamm. Res. | pmid:24077843 |
| Dasari B et al. | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. | 2013 | Curr. Eye Res. | pmid:23841471 |
| Xu M et al. | Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes. | 2013 | Biochim. Biophys. Acta | pmid:24095928 |
| Wang SF et al. | 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. | 2013 | Biochem. Pharmacol. | pmid:23792120 |
| Buttari B et al. | 7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages. | 2013 | Biochem. Pharmacol. | pmid:23611834 |
| GarcÃa RA et al. | 11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoEâ»/â» mice. | 2013 | PLoS ONE | pmid:23383297 |
| Wong D and Wang M | Inhibitory activities of some vitamins on the formation of cholesterol oxidation products in beef patties. | 2013 | J. Agric. Food Chem. | pmid:23937446 |
| Okabe A et al. | Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. | 2013 | Redox Biol | pmid:24371802 |
| Chung ML et al. | Profiling of oxidized lipid products of marine fish under acute oxidative stress. | 2013 | Food Chem. Toxicol. | pmid:23220612 |
| Daniil G et al. | Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux. | 2013 | PLoS ONE | pmid:23826352 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol. | 2013 | Biochimie | pmid:22940536 |
| Miah S et al. | Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. | 2013 | Exp. Toxicol. Pathol. | pmid:22999639 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. | 2013 | Biochem. Pharmacol. | pmid:23415904 |
| Ragot K et al. | Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23473804 |
| Loke SY et al. | Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. | 2013 | J. Neurochem. | pmid:23294445 |
| Yamagata K et al. | Epigallocatechin 3-gallate inhibits 7-ketocholesterol-induced monocyte-endothelial cell adhesion. | 2013 | Microvasc. Res. | pmid:23567873 |
| Helmschrodt C et al. | Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. | 2013 | Clin. Chim. Acta | pmid:23827692 |