7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leonarduzzi G et al. | Trojan horse-like behavior of a biologically representative mixture of oxysterols. | 2004 Feb-Apr | Mol. Aspects Med. | pmid:15051324 |
| Scopesi F et al. | Cholesterol oxidation in intravenous lipid emulsions: safety of preparations before and after experimental hyperoxia. | 2004 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:15449575 |
| Jessup W and Brown AJ | Novel routes for metabolism of 7-ketocholesterol. | 2005 | Rejuvenation Res | pmid:15798369 |
| Lee HS et al. | TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15993097 |
| Freeman NE et al. | Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages. | 2005 | J. Lipid Res. | pmid:15995174 |
| Berthier A et al. | 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways. | 2005 | FEBS J. | pmid:15955068 |
| Kasperczyk S et al. | Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead. | 2005 | Hum Exp Toxicol | pmid:16004195 |
| Miyashita Y et al. | Apoptosis induced by 7-ketocholesterol is enhanced in smooth muscle cells derived from OLETF rats. | 2005 | J. Atheroscler. Thromb. | pmid:15942119 |
| Lemaire-Ewing S et al. | Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. | 2005 | Cell Biol. Toxicol. | pmid:16142584 |
| Raith K et al. | A new LC/APCI-MS method for the determination of cholesterol oxidation products in food. | 2005 | J Chromatogr A | pmid:15844526 |
| Rimner A et al. | Relevance and mechanism of oxysterol stereospecifity in coronary artery disease. | 2005 | Free Radic. Biol. Med. | pmid:15649656 |
| Rosa A et al. | Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues. | 2005 | Toxicol. Lett. | pmid:15795088 |
| Rho MC et al. | 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death. | 2005 | J. Mol. Cell. Cardiol. | pmid:16198370 |
| Vejux A et al. | 7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionation. | 2005 | Cytometry A | pmid:15739183 |
| Massey JB and Pownall HJ | The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I. | 2005 | Biochemistry | pmid:16042420 |
| Yoshioka N et al. | Oxysterols increase in diabetic rats. | 2005 | Free Radic. Res. | pmid:15788234 |
| Sahai E et al. | Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. | 2005 | BMC Biotechnol. | pmid:15910685 |
| Prunet C et al. | Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study. | 2005 | J. Biochem. Mol. Toxicol. | pmid:16292754 |
| Corradini SG et al. | High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. | 2005 | Liver Transpl. | pmid:16258953 |
| Boaz M et al. | Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort. | 2005 | Nephron Clin Pract | pmid:15849477 |
| Leoni V et al. | Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis. | 2005 | J. Lipid Res. | pmid:15576852 |
| Kinumi T et al. | Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL. | 2005 | Free Radic. Res. | pmid:16298863 |
| Cheng YW et al. | Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. | 2005 | Food Chem. Toxicol. | pmid:15721210 |
| Brown BE et al. | Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells. | 2005 | Diabetologia | pmid:15660260 |
| Napolitano M and Bravo E | Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. | 2005 | Eur. J. Clin. Invest. | pmid:16101668 |
| Suh MH et al. | Antioxidative activity of microencapsulated gamma-oryzanol on high cholesterol-fed rats. | 2005 | J. Agric. Food Chem. | pmid:16332125 |
| Ozaki H et al. | Enhancement of MMP-9 activity in THP-1 cells by 7-ketocholesterol and its suppression by the HMG-CoA reductase inhibitor fluvastatin. | 2005 | J. Atheroscler. Thromb. | pmid:16394614 |
| Rosa A et al. | Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA. | 2005 | Free Radic. Res. | pmid:16298741 |
| Adachi J et al. | Enhanced lipid peroxidation in tourniquet-release mice. | 2006 | Clin. Chim. Acta | pmid:16624265 |
| Staprans I et al. | Ezetimibe inhibits the incorporation of dietary oxidized cholesterol into lipoproteins. | 2006 | J. Lipid Res. | pmid:16894239 |
| Naito Y et al. | Azelnidipine, a new calcium channel blocker, inhibits endothelial inflammatory response by reducing intracellular levels of reactive oxygen species. | 2006 | Eur. J. Pharmacol. | pmid:16919261 |
| Luthra S et al. | Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17122150 |
| Ohtsuka M et al. | Lipids deposited in human atheromatous lesions induce apoptosis of human vascular smooth muscle cells. | 2006 | J. Atheroscler. Thromb. | pmid:17146154 |
| Kiss L et al. | Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function. | 2006 | Int. J. Mol. Med. | pmid:17089016 |
| Lee JW et al. | Expression and localization of sterol 27-hydroxylase (CYP27A1) in monkey retina. | 2006 | Exp. Eye Res. | pmid:16549062 |
| Odermatt A et al. | Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1. | 2006 | Mol. Cell. Endocrinol. | pmid:16412558 |
| Kim YJ et al. | 7-Ketocholesterol enhances 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells. | 2006 | J Neural Transm | pmid:16715209 |
| Stanley N et al. | Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions. | 2006 | Free Radic. Biol. Med. | pmid:16632123 |
| Lee HW et al. | Formation of cholesterol oxidation products in marinated foods during heating. | 2006 | J. Agric. Food Chem. | pmid:16787042 |
| Lee CS et al. | Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor. | 2006 | Neuroreport | pmid:16407768 |
| Kahn E et al. | Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells. | 2006 | Anal. Quant. Cytol. Histol. | pmid:17220145 |
| Adachi J et al. | Skeletal muscle and liver oxysterols during fasting and alcohol exposure. | 2006 | Metab. Clin. Exp. | pmid:16324930 |
| Steffen Y et al. | Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio. | 2006 | Free Radic. Biol. Med. | pmid:16962939 |
| Larsson DA et al. | Oxysterol mixtures, in atheroma-relevant proportions, display synergistic and proapoptotic effects. | 2006 | Free Radic. Biol. Med. | pmid:16934673 |
| Hall MC | The effect of oxysterols, individually and as a representative mixture from food, on in vitro cultured bovine ovarian granulosa cells. | 2006 | Mol. Cell. Biochem. | pmid:16983501 |
| Nakagawa K et al. | Protective effect of daidzein against acute ethanol-induced lipid peroxidation in rat jejunum. | 2006 | Kobe J Med Sci | pmid:17006054 |
| Maeda Y et al. | Species differences among various rodents in the conversion of 7alpha-hydroxycholesterol in liver microsomes. | 2006 | Steroids | pmid:16455124 |
| Dushkin MI et al. | Effects of hydroxysterols and atorvastatin on lipopolysaccharide-induced secretion of tumor necrosis factor and interleukin-10 by mouse macrophages. | 2006 | Bull. Exp. Biol. Med. | pmid:16984105 |
| He X et al. | Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. | 2006 | J. Neuropathol. Exp. Neurol. | pmid:16825952 |
| Zunin P et al. | Sterol oxidation in meat- and fish-based homogenized baby foods containing vegetable oils. | 2006 Mar-Apr | J AOAC Int | pmid:16640291 |