7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zunin P et al. | Sterol oxidation in meat- and fish-based homogenized baby foods containing vegetable oils. | 2006 Mar-Apr | J AOAC Int | pmid:16640291 |
| Leonarduzzi G et al. | Early involvement of ROS overproduction in apoptosis induced by 7-ketocholesterol. | 2006 Mar-Apr | Antioxid. Redox Signal. | pmid:16677084 |
| Zhou L et al. | Different cytotoxic injuries induced by lysophosphatidylcholine and 7-ketocholesterol in mouse endothelial cells. | 2006 May-Jun | Endothelium | pmid:16840177 |
| Lee CS et al. | Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers. | 2007 | Neurochem. Res. | pmid:17151911 |
| Han JH et al. | Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition. | 2007 | Brain Res. | pmid:17224136 |
| Javitt NB | Oxysterols: functional significance in fetal development and the maintenance of normal retinal function. | 2007 | Curr. Opin. Lipidol. | pmid:17495602 |
| Rittmann BE and Schloendorn J | Engineering away lysosomal junk: medical bioremediation. | 2007 | Rejuvenation Res | pmid:17708688 |
| Fuda H et al. | Oxysterols are substrates for cholesterol sulfotransferase. | 2007 | J. Lipid Res. | pmid:17347498 |
| Palozza P et al. | Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages. | 2007 | Free Radic. Biol. Med. | pmid:17448905 |
| Mazalli MR and Bragagnolo N | Effect of storage on cholesterol oxide formation and fatty acid alterations in egg powder. | 2007 | J. Agric. Food Chem. | pmid:17348676 |
| Ferderbar S et al. | Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. | 2007 | Diabetes Metab. Res. Rev. | pmid:16634125 |
| Nashev LG et al. | Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. | 2007 | PLoS ONE | pmid:17593962 |
| Vitha MF and Clarke RJ | Comparison of excitation and emission ratiometric fluorescence methods for quantifying the membrane dipole potential. | 2007 | Biochim. Biophys. Acta | pmid:16904627 |
| Arca M et al. | Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy. | 2007 | Free Radic. Biol. Med. | pmid:17291993 |
| Erridge C et al. | 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. | 2007 | Free Radic. Res. | pmid:17364953 |
| Larsson H et al. | In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress. | 2007 | Free Radic. Biol. Med. | pmid:17664133 |
| Saldanha T and Bragagnolo N | Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi). | 2007 | Lipids | pmid:17492472 |
| Piga R et al. | Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants. | 2007 | Neurotoxicology | pmid:16942797 |
| Fülöp T et al. | Immunosupportive therapies in aging. | 2007 | Clin Interv Aging | pmid:18044074 |
| Kim JS et al. | Cytoprotective effect of polysaccharide isolated from different mushrooms against 7-ketocholesterol induced damage in mouse liver cell line (BNL CL. 2). | 2007 | Nutr Res Pract | pmid:20368935 |
| Myoishi M et al. | Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. | 2007 | Circulation | pmid:17709641 |
| Vejux A et al. | Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: investigation by flow cytometry and spectral imaging microscopy. | 2007 | Cytometry A | pmid:17458884 |
| Jiang X et al. | Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17154356 |
| Farooqui AA et al. | Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. | 2007 | Brain Res Rev | pmid:17959252 |
| Bravo E and Napolitano M | Mechanisms involved in chylomicron remnant lipid uptake by macrophages. | 2007 | Biochem. Soc. Trans. | pmid:17511627 |
| Sasaki H et al. | Vascular smooth muscle cell apoptosis induced by 7-ketocholesterol was mediated via Ca2+ and inhibited by the calcium channel blocker nifedipine. | 2007 | Metab. Clin. Exp. | pmid:17292724 |
| Wen Y and Leake DS | Low density lipoprotein undergoes oxidation within lysosomes in cells. | 2007 | Circ. Res. | pmid:17446432 |
| Neekhra A et al. | Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17325185 |
| Deiana M et al. | Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate. | 2007 | Food Chem. Toxicol. | pmid:17686562 |
| Joffre C et al. | Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. | 2007 | Curr. Eye Res. | pmid:17453947 |
| Terasaka N et al. | High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17846428 |
| Rentero C et al. | Functional implications of plasma membrane condensation for T cell activation. | 2008 | PLoS ONE | pmid:18509459 |
| Deiana M et al. | Protective effect of hydroxytyrosol and its metabolite homovanillic alcohol on H(2)O(2) induced lipid peroxidation in renal tubular epithelial cells. | 2008 | Food Chem. Toxicol. | pmid:18588937 |
| Bach D et al. | Interaction of 7-ketocholesterol with two major components of the inner leaflet of the plasma membrane: phosphatidylethanolamine and phosphatidylserine. | 2008 | Biochemistry | pmid:18247524 |
| Rosa A et al. | Protective effect of the oligomeric acylphloroglucinols from Myrtus communis on cholesterol and human low density lipoprotein oxidation. | 2008 | Chem. Phys. Lipids | pmid:18498764 |
| Borlak J and Jenke HS | Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation. | 2008 | Mol. Cancer Res. | pmid:18708364 |
| Noguchi N | Role of oxidative stress in adaptive responses in special reference to atherogenesis. | 2008 | J Clin Biochem Nutr | pmid:19015746 |
| Lee CY et al. | Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. | 2008 | Free Radic. Biol. Med. | pmid:18226605 |
| Vejux A et al. | Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis. | 2008 | Braz. J. Med. Biol. Res. | pmid:18719735 |
| Terasaka N et al. | ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. | 2008 | J. Clin. Invest. | pmid:18924609 |
| Rosa A et al. | Protective effect of vanilloids against tert-butyl hydroperoxide-induced oxidative stress in vero cells culture. | 2008 | J. Agric. Food Chem. | pmid:18439017 |
| Freeman-Anderson NE et al. | Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. | 2008 | J. Lipid Res. | pmid:18614816 |
| Ferioli F et al. | Evaluation of cholesterol and lipid oxidation in raw and cooked minced beef stored under oxygen-enriched atmosphere. | 2008 | Meat Sci. | pmid:22063582 |
| Alkazemi D et al. | Oxysterol as a marker of atherogenic dyslipidemia in adolescence. | 2008 | J. Clin. Endocrinol. Metab. | pmid:18713821 |
| Wamil M et al. | 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. | 2008 | Endocrinology | pmid:18755798 |
| Gerry AB et al. | A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein. | 2008 | Atherosclerosis | pmid:17945239 |
| Luthra S et al. | 7-Ketocholesterol activates caspases-3/7, -8, and -12 in human microvascular endothelial cells in vitro. | 2008 | Microvasc. Res. | pmid:18068200 |
| Romeo GR and Kazlauskas A | Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. | 2008 | J. Biol. Chem. | pmid:18230613 |
| Endo K et al. | Determination of serum 7-ketocholesterol concentrations and their relationships with coronary multiple risks in diabetes mellitus. | 2008 | Diabetes Res. Clin. Pract. | pmid:18207277 |
| Palozza P et al. | The protective role of carotenoids against 7-keto-cholesterol formation in solution. | 2008 | Mol. Cell. Biochem. | pmid:18008144 |