7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Son SH et al. | Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages. | 2012 | PLoS ONE | pmid:22427949 |
| Mathieu JM et al. | Increased resistance to oxysterol cytotoxicity in fibroblasts transfected with a lysosomally targeted Chromobacterium oxidase. | 2012 | Biotechnol. Bioeng. | pmid:22447444 |
| Lai YL et al. | Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases. | 2012 | J Clin Biochem Nutr | pmid:22247606 |
| Pédeboscq S et al. | Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro. | 2012 | PLoS ONE | pmid:22590613 |
| Gui T et al. | Diverse roles of macrophages in atherosclerosis: from inflammatory biology to biomarker discovery. | 2012 | Mediators Inflamm. | pmid:22577254 |
| Katsuyama M et al. | Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. | 2012 | J Clin Biochem Nutr | pmid:22247596 |
| Ostrowska M et al. | Cerebrotendinous xanthomatosis: a rare cause of spinocerebellar syndrome. | 2011 Nov-Dec | Neurol. Neurochir. Pol. | pmid:22212991 |
| Aluf Y et al. | Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule. | 2011 Jul-Aug | Neuropharmacology | pmid:21414328 |
| Menéndez-Carreño M et al. | Correlation between serum content of the main COPs (cholesterol oxidation products) from autoxidation and cardiovascular risk factors. | 2011 Jan-Feb | Nutr Hosp | pmid:21519741 |
| Ebrahimi KB and Handa JT | Lipids, lipoproteins, and age-related macular degeneration. | 2011 | J Lipids | pmid:21822496 |
| Magenau A et al. | Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. | 2011 | Traffic | pmid:21883764 |
| Palozza P et al. | Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression. | 2011 | J. Nutr. Biochem. | pmid:20573495 |
| Flück CE et al. | Characterization of novel StAR (steroidogenic acute regulatory protein) mutations causing non-classic lipoid adrenal hyperplasia. | 2011 | PLoS ONE | pmid:21647419 |
| Marchetti V et al. | Differential macrophage polarization promotes tissue remodeling and repair in a model of ischemic retinopathy. | 2011 | Sci Rep | pmid:22355595 |
| Itabe H et al. | The Dynamics of Oxidized LDL during Atherogenesis. | 2011 | J Lipids | pmid:21660303 |
| Aye IL et al. | Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | 2011 | Placenta | pmid:21208656 |
| Le Lay S et al. | Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. | 2011 | PLoS ONE | pmid:21858084 |
| Rosa A et al. | Protective role of arzanol against lipid peroxidation in biological systems. | 2011 | Chem. Phys. Lipids | pmid:20932961 |
| Shinkyo R et al. | Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. | 2011 | J. Biol. Chem. | pmid:21813643 |
| Xu L et al. | Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. | 2011 | J. Lipid Res. | pmid:21817059 |