7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
To understand associated biological information of 7-Ketocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Ketocholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, endothelial dysfunction, Senile Plaques, Hypercholesterolemia, Hypercholesterolemia, Familial and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7-Ketocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.' (Hakamata H et al., 1998) and Knock-out are used in the study 'Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.' (Hans CP et al., 2008).
Mouse Model are used in the study 'Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.' (Luthra S et al., 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Inouye M et al. | Glycated hemoglobin and lipid peroxidation in erythrocytes of diabetic patients. | 1999 | Metab. Clin. Exp. | pmid:10024083 |
| van Reyk DM et al. | Prooxidant and antioxidant activities of macrophages in metal-mediated LDL oxidation: the importance of metal sequestration. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195944 |
| Myers SJ and Stanley KK | Src family kinase activation in glycosphingolipid-rich membrane domains of endothelial cells treated with oxidised low density lipoprotein. | 1999 | Atherosclerosis | pmid:10217369 |
| Lyons MA and Brown AJ | 7-Ketocholesterol. | 1999 Mar-Apr | Int. J. Biochem. Cell Biol. | pmid:10224662 |
| Lizard G et al. | Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10323769 |
| Zarev S et al. | Major differences in oxysterol formation in human low density lipoproteins (LDLs) oxidized by *OH/O2*- free radicals or by copper. | 1999 | FEBS Lett. | pmid:10371147 |
| Gelissen IC et al. | Oxysterol efflux from macrophage foam cells: the essential role of acceptor phospholipid. | 1999 | J. Lipid Res. | pmid:10484610 |
| Urano Y et al. | Vascular smooth muscle cell outgrowth, proliferation, and apoptosis in young and old rats. | 1999 | Atherosclerosis | pmid:10487492 |
| Lyons MA et al. | Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols. | 1999 | J. Lipid Res. | pmid:10508204 |
| Pirillo A et al. | Oxysterols from oxidized LDL are cytotoxic but fail to induce hsp70 expression in endothelial cells. | 1999 | FEBS Lett. | pmid:10580102 |
| Rao ML et al. | Induction of apoptosis and necrosis in human neuroblastoma cells by cholesterol oxides. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10672272 |
| Brown AJ et al. | Cholesterol and oxysterol metabolism and subcellular distribution in macrophage foam cells. Accumulation of oxidized esters in lysosomes. | 2000 | J. Lipid Res. | pmid:10681406 |
| Lizard G et al. | Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis. | 2000 | Free Radic. Biol. Med. | pmid:10754270 |
| Tsuzuki D et al. | Analysis of 7-ketocholesterol in low density lipoprotein and fatty acid composition in erythrocyte membranes of patients on maintenance hemodialysis and healthy controls. | 2000 | Clin. Chim. Acta | pmid:10767401 |
| Hakamata H et al. | Cytotoxic effect of oxidized low density lipoprotein on macrophages. | 1998 | J. Atheroscler. Thromb. | pmid:10855560 |
| Brown AJ et al. | Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. | 2000 | J. Biol. Chem. | pmid:10869358 |
| Yoshida T et al. | Cholestan-3beta,5alpha,6beta-triol, but not 7-ketocholesterol, suppresses taurocholate-induced mucin secretion by cultured dog gallbladder epithelial cells. | 2000 | FEBS Lett. | pmid:10922480 |
| Liao HS et al. | Expression of class A scavenger receptor inhibits apoptosis of macrophages triggered by oxidized low density lipoprotein and oxysterol. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10938019 |
| Norlin M et al. | 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). | 2000 | J. Lipid Res. | pmid:11013305 |
| Perségol L et al. | Co-incubation of native and oxidized low-density lipoproteins: potentiation of relaxation impairment. | 2000 | Eur. J. Pharmacol. | pmid:11040350 |
| Savouret JF et al. | 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor. | 2001 | J. Biol. Chem. | pmid:11042205 |
| Bourdon E et al. | Involvement of oxysterols and lysophosphatidylcholine in the oxidized LDL-induced impairment of serum albumin synthesis by HEPG2 cells. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11116066 |
| Abo K et al. | Comparative analysis of plasma and erythrocyte 7-ketocholesterol as a marker for oxidative stress in patients with diabetes mellitus. | 2000 | Clin. Biochem. | pmid:11124339 |
| Song C et al. | Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis. | 2001 | Steroids | pmid:11182136 |
| Tomasik A et al. | Impact of baseline level of 7-ketocholesterol on the rate of coronary reintervention in coronary artery disease patients--results of an observational study with questionnaire-based follow up. | 2000 Jul-Aug | Med. Sci. Monit. | pmid:11208404 |
| Lee JI et al. | Formation of cholesterol oxides in irradiated raw and cooked chicken meat during storage. | 2001 | Poult. Sci. | pmid:11214329 |
| Lyons MA and Brown AJ | 7-Ketocholesterol delivered to mice in chylomicron remnant-like particles is rapidly metabolised, excreted and does not accumulate in aorta. | 2001 | Biochim. Biophys. Acta | pmid:11239823 |
| Hamilton JA et al. | Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL. | 2001 | Biochem. J. | pmid:11256965 |
| Moreira EF et al. | Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. | 2001 | J. Biol. Chem. | pmid:11278871 |
| Han J et al. | Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I. | 2001 | J. Biol. Chem. | pmid:11278882 |
| Burnett JR et al. | Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. | 2001 | Clin. Chim. Acta | pmid:11282095 |
| Thomas SR et al. | Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout mice. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11304477 |
| Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
| Tamasawa N et al. | An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture. | 2001 | Biochim. Biophys. Acta | pmid:11325610 |
| Kimura T et al. | Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | 2001 | J. Biol. Chem. | pmid:11427538 |
| Gaus K et al. | A kinetic model to evaluate cholesterol efflux from THP-1 macrophages to apolipoprotein A-1. | 2001 | Biochemistry | pmid:11478905 |
| Miyajima H et al. | Increased oxysterols associated with iron accumulation in the brains and visceral organs of acaeruloplasminaemia patients. | 2001 | QJM | pmid:11493718 |
| O'Callaghan YC et al. | Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols. | 2001 | Cell Biol. Toxicol. | pmid:11499696 |
| Englund MC et al. | 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages. | 2001 | Atherosclerosis | pmid:11500175 |
| Smondyrev AM and Berkowitz ML | Effects of oxygenated sterol on phospholipid bilayer properties: a molecular dynamics simulation. | 2001 | Chem. Phys. Lipids | pmid:11518570 |
| Lyons MA and Brown AJ | Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells. | 2001 | Lipids | pmid:11521968 |
| Skrzep-Poloczek B et al. | Nephrotic origin hyperlipidemia, relative reduction of vitamin E level and subsequent oxidative stress may promote atherosclerosis. | 2001 | Nephron | pmid:11528235 |
| Iuliano L et al. | Bioavailability of vitamin E as function of food intake in healthy subjects: effects on plasma peroxide-scavenging activity and cholesterol-oxidation products. | 2001 | Arterioscler. Thromb. Vasc. Biol. | pmid:11597949 |
| Gaus K et al. | Inhibition of cholesterol efflux by 7-ketocholesterol: comparison between cells, plasma membrane vesicles, and liposomes as cholesterol donors. | 2001 | Biochemistry | pmid:11669638 |
| Sleer LS et al. | Interaction of caveolin with 7-ketocholesterol. | 2001 | Atherosclerosis | pmid:11689206 |
| Phillips JE et al. | 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells. | 2001 | Atherosclerosis | pmid:11689214 |
| Echarte M et al. | Oxidation process affecting fatty acids and cholesterol in fried and roasted salmon. | 2001 | J. Agric. Food Chem. | pmid:11714374 |
| Dulak J et al. | Vascular endothelial growth factor synthesis in vascular smooth muscle cells is enhanced by 7-ketocholesterol and lysophosphatidylcholine independently of their effect on nitric oxide generation. | 2001 | Atherosclerosis | pmid:11730812 |
| Van Cantfort J and Gielen J | Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro. | 1975 | Eur. J. Biochem. | pmid:1175606 |