| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperlipoproteinemias | D006951 | 15 associated lipids |
Total
1
Cholestane-3beta,5alpha,6beta-triol
Cholestane-3beta,5alpha,6beta-triol is a lipid of Sterol Lipids (ST) class. Cholestane-3beta,5alpha,6beta-triol is associated with abnormalities such as Niemann-Pick Diseases, Hypercholesterolemia, Familial, Xanthomatosis, Cerebrotendinous, Neurodegenerative Disorders and Metabolic Diseases. The involved functions are known as Adjudication, Oxidation, Mutation, cholesterol transport and Process. Cholestane-3beta,5alpha,6beta-triol often locates in Lysosomal, Blood, Body tissue, peroxisome and Cytoplasmic Granules. The associated genes with Cholestane-3beta,5alpha,6beta-triol are CALCA gene, NPC2 gene, Alleles, SNW1 Gene and ADRBK1 gene. The related lipids are 7-ketocholesterol, Sterols and Cholestanes.
Cross Reference
Introduction
To understand associated biological information of Cholestane-3beta,5alpha,6beta-triol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cholestane-3beta,5alpha,6beta-triol?
Cholestane-3beta,5alpha,6beta-triol is suspected in Hypercholesterolemia, Familial, Galactosemias, Liver diseases, Niemann-Pick Diseases, Xanthomatosis, Cerebrotendinous, Metabolic Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cholestane-3beta,5alpha,6beta-triol
PubChem Associated disorders and diseases
What pathways are associated with Cholestane-3beta,5alpha,6beta-triol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cholestane-3beta,5alpha,6beta-triol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Cholestane-3beta,5alpha,6beta-triol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Cholestane-3beta,5alpha,6beta-triol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Cholestane-3beta,5alpha,6beta-triol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Cholestane-3beta,5alpha,6beta-triol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Cholestane-3beta,5alpha,6beta-triol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tang L et al. | Cholestane-3β, 5α, 6β-triol suppresses neuronal hyperexcitability via binding to voltage-gated sodium channels. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29307820 |
| Soules R et al. | Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS. | 2017 | Chem. Phys. Lipids | pmid:28554594 |
| Kannenberg F et al. | Determination of serum cholestane-3β,5α,6β-triol by gas chromatography-mass spectrometry for identification of Niemann-Pick type C (NPC) disease. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26940355 |
| Boenzi S et al. | Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism. | 2016 | J. Lipid Res. | pmid:26733147 |
| Ribas GS et al. | Selective screening of Niemann-Pick type C Brazilian patients by cholestane-3β,5α,6β-triol and chitotriosidase measurements followed by filipin staining and NPC1/NPC2 gene analysis. | 2016 | Clin. Chim. Acta | pmid:27234403 |
| Reunert J et al. | Rapid Diagnosis of 83 Patients with Niemann Pick Type C Disease and Related Cholesterol Transport Disorders by Cholestantriol Screening. | 2016 | EBioMedicine | pmid:26981555 |
| Pajares S et al. | Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency. | 2015 | J. Lipid Res. | pmid:26239048 |
| Yan M et al. | Characterization of a Synthetic Steroid 24-keto-cholest-5-en-3β, 19-diol as a Neuroprotectant. | 2015 | CNS Neurosci Ther | pmid:25678034 |
| Tang L et al. | Cholesterol metabolite cholestane-3β,5α,6β-triol suppresses epileptic seizures by negative modulation of voltage-gated sodium channels. | 2015 | Steroids | pmid:25578735 |
| Hu H et al. | The major cholesterol metabolite cholestane-3β,5α,6β-triol functions as an endogenous neuroprotectant. | 2014 | J. Neurosci. | pmid:25143622 |