Cholestane-3beta,5alpha,6beta-triol

Cholestane-3beta,5alpha,6beta-triol is a lipid of Sterol Lipids (ST) class. Cholestane-3beta,5alpha,6beta-triol is associated with abnormalities such as Niemann-Pick Diseases, Hypercholesterolemia, Familial, Xanthomatosis, Cerebrotendinous, Neurodegenerative Disorders and Metabolic Diseases. The involved functions are known as Adjudication, Oxidation, Mutation, cholesterol transport and Process. Cholestane-3beta,5alpha,6beta-triol often locates in Lysosomal, Blood, Body tissue, peroxisome and Cytoplasmic Granules. The associated genes with Cholestane-3beta,5alpha,6beta-triol are CALCA gene, NPC2 gene, Alleles, SNW1 Gene and ADRBK1 gene. The related lipids are 7-ketocholesterol, Sterols and Cholestanes.

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Introduction

To understand associated biological information of Cholestane-3beta,5alpha,6beta-triol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cholestane-3beta,5alpha,6beta-triol?

Cholestane-3beta,5alpha,6beta-triol is suspected in Hypercholesterolemia, Familial, Galactosemias, Liver diseases, Niemann-Pick Diseases, Xanthomatosis, Cerebrotendinous, Metabolic Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cholestane-3beta,5alpha,6beta-triol

MeSH term MeSH ID Detail
Hyperlipoproteinemias D006951 15 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Cholestane-3beta,5alpha,6beta-triol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cholestane-3beta,5alpha,6beta-triol?

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What functions are associated with Cholestane-3beta,5alpha,6beta-triol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cholestane-3beta,5alpha,6beta-triol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cholestane-3beta,5alpha,6beta-triol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cholestane-3beta,5alpha,6beta-triol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Cholestane-3beta,5alpha,6beta-triol

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Authors Title Published Journal PubMed Link
Tang R and Huang K Inhibiting effect of selenium on oxysterols-induced apoptosis of rat vascular smooth muscle cells. 2004 J. Inorg. Biochem. pmid:15522395
Liu H et al. Cholestane-3beta, 5alpha, 6beta-triol promotes vascular smooth muscle cells calcification. 2004 Life Sci. pmid:15556166
Cheng YW et al. Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. 2005 Food Chem. Toxicol. pmid:15721210
Rontani JF and Aubert C Electron ionization mass spectral fragmentation of cholestane-3beta,4alpha,5alpha-triol and cholestane-3beta,5alpha,6alpha/beta-triol bis- and tris-trimethylsilyl derivatives. 2005 Rapid Commun. Mass Spectrom. pmid:15954177
Nakazawa T et al. Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo. 2005 J. Atheroscler. Thromb. pmid:16020912
Tang R et al. Mechanisms of selenium inhibition of cell apoptosis induced by oxysterols in rat vascular smooth muscle cells. 2005 Arch. Biochem. Biophys. pmid:16039982
Liu H et al. Cholestane-3beta,5alpha,6beta-triol inhibits osteoblastic differentiation and promotes apoptosis of rat bone marrow stromal cells. 2005 J. Cell. Biochem. pmid:16052487
Dzikovski B et al. High-field ESR on aligned membranes: a simple method to record spectra from different membrane orientations in the magnetic field. 2006 J. Magn. Reson. pmid:16427793
Wu Q and Huang K Protective effect of ebselen on cytotoxicity induced by cholestane-3 beta, 5 alpha, 6 beta-triol in ECV-304 cells. 2006 Biochim. Biophys. Acta pmid:16581291
Ferderbar S et al. Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. 2007 Diabetes Metab. Res. Rev. pmid:16634125