MeSH term | MeSH ID | Detail |
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Hyperlipoproteinemias | D006951 | 15 associated lipids |
Cholestane-3beta,5alpha,6beta-triol is a lipid of Sterol Lipids (ST) class. Cholestane-3beta,5alpha,6beta-triol is associated with abnormalities such as Niemann-Pick Diseases, Hypercholesterolemia, Familial, Xanthomatosis, Cerebrotendinous, Neurodegenerative Disorders and Metabolic Diseases. The involved functions are known as Adjudication, Oxidation, Mutation, cholesterol transport and Process. Cholestane-3beta,5alpha,6beta-triol often locates in Lysosomal, Blood, Body tissue, peroxisome and Cytoplasmic Granules. The associated genes with Cholestane-3beta,5alpha,6beta-triol are CALCA gene, NPC2 gene, Alleles, SNW1 Gene and ADRBK1 gene. The related lipids are 7-ketocholesterol, Sterols and Cholestanes.
To understand associated biological information of Cholestane-3beta,5alpha,6beta-triol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cholestane-3beta,5alpha,6beta-triol is suspected in Hypercholesterolemia, Familial, Galactosemias, Liver diseases, Niemann-Pick Diseases, Xanthomatosis, Cerebrotendinous, Metabolic Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cholestane-3beta,5alpha,6beta-triol
MeSH term | MeSH ID | Detail |
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Hyperlipoproteinemias | D006951 | 15 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tang R and Huang K | Inhibiting effect of selenium on oxysterols-induced apoptosis of rat vascular smooth muscle cells. | 2004 | J. Inorg. Biochem. | pmid:15522395 |
Liu H et al. | Cholestane-3beta, 5alpha, 6beta-triol promotes vascular smooth muscle cells calcification. | 2004 | Life Sci. | pmid:15556166 |
Cheng YW et al. | Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation. | 2005 | Food Chem. Toxicol. | pmid:15721210 |
Rontani JF and Aubert C | Electron ionization mass spectral fragmentation of cholestane-3beta,4alpha,5alpha-triol and cholestane-3beta,5alpha,6alpha/beta-triol bis- and tris-trimethylsilyl derivatives. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15954177 |
Nakazawa T et al. | Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo. | 2005 | J. Atheroscler. Thromb. | pmid:16020912 |
Tang R et al. | Mechanisms of selenium inhibition of cell apoptosis induced by oxysterols in rat vascular smooth muscle cells. | 2005 | Arch. Biochem. Biophys. | pmid:16039982 |
Liu H et al. | Cholestane-3beta,5alpha,6beta-triol inhibits osteoblastic differentiation and promotes apoptosis of rat bone marrow stromal cells. | 2005 | J. Cell. Biochem. | pmid:16052487 |
Dzikovski B et al. | High-field ESR on aligned membranes: a simple method to record spectra from different membrane orientations in the magnetic field. | 2006 | J. Magn. Reson. | pmid:16427793 |
Wu Q and Huang K | Protective effect of ebselen on cytotoxicity induced by cholestane-3 beta, 5 alpha, 6 beta-triol in ECV-304 cells. | 2006 | Biochim. Biophys. Acta | pmid:16581291 |
Ferderbar S et al. | Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. | 2007 | Diabetes Metab. Res. Rev. | pmid:16634125 |