MeSH term | MeSH ID | Detail |
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Limb Deformities, Congenital | D017880 | 4 associated lipids |
Zymosterol is a lipid of Sterol Lipids (ST) class. Zymosterol is associated with abnormalities such as Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease and Virus Diseases. The involved functions are known as Process, enzyme activity, Anabolism, Transcription, Genetic and Synthesis. Zymosterol often locates in Cytosol, Mitochondria, Articular system, Protoplasm and Tissue membrane. The associated genes with Zymosterol are Genome, Homologous Gene, Amino Acids, Acidic, Peptide Fragments and DLC1 gene. The related lipids are zymosterol, Cardiolipins, 25-azacholesterol, Sterols and Steroids. The related experimental models are Knock-out.
To understand associated biological information of Zymosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zymosterol is suspected in Leishmaniasis, Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Zymosterol
MeSH term | MeSH ID | Detail |
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Limb Deformities, Congenital | D017880 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major.' (Chavali AK et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Berthois Y et al. | SR31747A is a sigma receptor ligand exhibiting antitumoural activity both in vitro and in vivo. | 2003 | Br. J. Cancer | pmid:12569389 |
Sukhanova A et al. | Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. | 2013 | Cancer Discov | pmid:23125191 |
Suárez Y et al. | Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. | 2004 | Cardiovasc. Res. | pmid:15485695 |
Nes WD | Biosynthesis of cholesterol and other sterols. | 2011 | Chem. Rev. | pmid:21902244 |
HÄ…c-Wydro K et al. | The comparison of zymosterol vs cholesterol membrane properties--the effect of zymosterol on lipid monolayers. | 2014 | Colloids Surf B Biointerfaces | pmid:25444659 |
Jokela H et al. | Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos. | 2010 | Endocrinology | pmid:20185768 |
Chen JK et al. | Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. | 1986 | Exp. Cell Res. | pmid:3943557 |
Soustre I et al. | Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae. | 2000 | FEBS Lett. | pmid:10734216 |
Veen M et al. | Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. | 2003 | FEMS Yeast Res. | pmid:14554200 |
Kloimwieder A and Winston F | A Screen for Germination Mutants in Saccharomyces cerevisiae. | 2011 | G3 (Bethesda) | pmid:22384326 |