MeSH term | MeSH ID | Detail |
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Limb Deformities, Congenital | D017880 | 4 associated lipids |
Zymosterol is a lipid of Sterol Lipids (ST) class. Zymosterol is associated with abnormalities such as Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease and Virus Diseases. The involved functions are known as Process, enzyme activity, Anabolism, Transcription, Genetic and Synthesis. Zymosterol often locates in Cytosol, Mitochondria, Articular system, Protoplasm and Tissue membrane. The associated genes with Zymosterol are Genome, Homologous Gene, Amino Acids, Acidic, Peptide Fragments and DLC1 gene. The related lipids are zymosterol, Cardiolipins, 25-azacholesterol, Sterols and Steroids. The related experimental models are Knock-out.
To understand associated biological information of Zymosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Zymosterol is suspected in Leishmaniasis, Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Zymosterol
MeSH term | MeSH ID | Detail |
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Limb Deformities, Congenital | D017880 | 4 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major.' (Chavali AK et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Huijmans JG et al. | Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. | 1981 | Acta Endocrinol. | pmid:6263029 |
Qi Y et al. | Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition. | 2017 | Appl. Environ. Microbiol. | pmid:28710262 |
Nes WD et al. | Yeast sterol C24-methyltransferase: role of highly conserved tyrosine-81 in catalytic competence studied by site-directed mutagenesis and thermodynamic analysis. | 2008 | Arch. Biochem. Biophys. | pmid:18555004 |
Nes WD et al. | Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae. | 1997 | Arch. Biochem. Biophys. | pmid:9185615 |
Zhou W and Nes WD | Sterol methyltransferase2: purification, properties, and inhibition. | 2003 | Arch. Biochem. Biophys. | pmid:14622971 |
Ganapathy K et al. | Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans. | 2011 | Arch. Biochem. Biophys. | pmid:20946868 |
Nes WD et al. | Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. | 2009 | Arch. Biochem. Biophys. | pmid:19014901 |
Pikuleva I and Javitt NB | Novel sterols synthesized via the CYP27A1 metabolic pathway. | 2003 | Arch. Biochem. Biophys. | pmid:14622972 |
ALEXANDER GJ and SCHWENK E | Studies on biosynthesis of cholesterol. IX. Zymosterol as a precursor of cholesterol. | 1957 | Arch. Biochem. Biophys. | pmid:13403684 |