Zymosterol

Zymosterol is a lipid of Sterol Lipids (ST) class. Zymosterol is associated with abnormalities such as Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease and Virus Diseases. The involved functions are known as Process, enzyme activity, Anabolism, Transcription, Genetic and Synthesis. Zymosterol often locates in Cytosol, Mitochondria, Articular system, Protoplasm and Tissue membrane. The associated genes with Zymosterol are Genome, Homologous Gene, Amino Acids, Acidic, Peptide Fragments and DLC1 gene. The related lipids are zymosterol, Cardiolipins, 25-azacholesterol, Sterols and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of Zymosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Zymosterol?

Zymosterol is suspected in Leishmaniasis, Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease, Virus Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Zymosterol

MeSH term MeSH ID Detail
Limb Deformities, Congenital D017880 4 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Zymosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Zymosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Zymosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Zymosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Zymosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Zymosterol?

Knock-out

Knock-out are used in the study 'Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major.' (Chavali AK et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Zymosterol

Download all related citations
Per page 10 20 50 100 | Total 82
Authors Title Published Journal PubMed Link
Qi Y et al. Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition. 2017 Appl. Environ. Microbiol. pmid:28710262
HÄ…c-Wydro K et al. The influence of cholesterol precursor--desmosterol--on artificial lipid membranes. 2015 Biochim. Biophys. Acta pmid:25960185
Medina JM et al. Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine. 2015 Mem. Inst. Oswaldo Cruz pmid:25742263
HÄ…c-Wydro K et al. The comparison of zymosterol vs cholesterol membrane properties--the effect of zymosterol on lipid monolayers. 2014 Colloids Surf B Biointerfaces pmid:25444659
Sukhanova A et al. Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. 2013 Cancer Discov pmid:23125191
Shin GH et al. Overexpression of genes of the fatty acid biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. 2012 Yeast pmid:22926964
Lange Y et al. Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. 2012 PLoS ONE pmid:22276143
McDonald JG et al. A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. 2012 J. Lipid Res. pmid:22517925
Alvarez-Vasquez F et al. Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. 2011 PLoS ONE pmid:22194828
Kloimwieder A and Winston F A Screen for Germination Mutants in Saccharomyces cerevisiae. 2011 G3 (Bethesda) pmid:22384326
Kawashima H et al. Differences in sterol composition of gonads of the lottiid limpets Nipponacmea concinna and Nipponacmea fuscoviridis from northeastern Japan. 2011 J Oleo Sci pmid:21937849
Hameed S et al. Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans. 2011 PLoS ONE pmid:21533276
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Ganapathy K et al. Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans. 2011 Arch. Biochem. Biophys. pmid:20946868
Gleason JE et al. Analysis of hypoxia and hypoxia-like states through metabolite profiling. 2011 PLoS ONE pmid:21931840
Alvarez-Rueda N et al. Amino acid substitutions at the major insertion loop of Candida albicans sterol 14alpha-demethylase are involved in fluconazole resistance. 2011 PLoS ONE pmid:21698128
Liu J et al. Effect of substrate features and mutagenesis of active site tyrosine residues on the reaction course catalysed by Trypanosoma brucei sterol C-24-methyltransferase. 2011 Biochem. J. pmid:21736559
Cheng D et al. Lipid pathway alterations in Parkinson's disease primary visual cortex. 2011 PLoS ONE pmid:21387008
Singh A and Prasad R Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints. 2011 PLoS ONE pmid:21559392
Vargas FA et al. Expanding a dynamic flux balance model of yeast fermentation to genome-scale. 2011 BMC Syst Biol pmid:21595919
Blanc M et al. Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. 2011 PLoS Biol. pmid:21408089
Jokela H et al. Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos. 2010 Endocrinology pmid:20185768
Fon Tacer K et al. Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. 2010 J. Steroid Biochem. Mol. Biol. pmid:20206258
Kawashima H et al. Differences in sterol composition between male and female gonads of dominant limpet species. 2009 Lipids pmid:19452182
de Souza W and Rodrigues JC Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. 2009 Interdiscip Perspect Infect Dis pmid:19680554
Leszczynska A et al. Investigating the effects of statins on cellular lipid metabolism using a yeast expression system. 2009 PLoS ONE pmid:20041128
Nes WD et al. Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans. 2009 Arch. Biochem. Biophys. pmid:19014901
Acimovic J et al. Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. 2009 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:19525158
Ishida K et al. Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms. 2009 BMC Microbiol. pmid:19379501
Rintala E et al. Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae. 2009 BMC Genomics pmid:19804647
Cimini D et al. Global transcriptional response of Saccharomyces cerevisiae to the deletion of SDH3. 2009 BMC Syst Biol pmid:19200357
Nes WD et al. Yeast sterol C24-methyltransferase: role of highly conserved tyrosine-81 in catalytic competence studied by site-directed mutagenesis and thermodynamic analysis. 2008 Arch. Biochem. Biophys. pmid:18555004
Snitkin ES et al. Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions. 2008 Genome Biol. pmid:18808699
Andersen MR et al. Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger. 2008 Mol. Syst. Biol. pmid:18364712
Chavali AK et al. Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major. 2008 Mol. Syst. Biol. pmid:18364711
Vinci G et al. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. 2008 PLoS ONE pmid:18682733
Iwaki T et al. Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe. 2008 Microbiology (Reading, Engl.) pmid:18310029
Cushion MT et al. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. 2007 PLoS ONE pmid:17487271
Steffensen KR et al. Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes. 2006 Mol. Cell. Endocrinol. pmid:16895745
Megha O et al. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. 2006 J. Biol. Chem. pmid:16735517
Yang C et al. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. 2006 J. Biol. Chem. pmid:16857673
Zhou W et al. Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei. 2006 J. Biol. Chem. pmid:16414960
Chemler JA et al. Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. 2006 Microb. Cell Fact. pmid:16719921
Liu H et al. Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme. 2005 J. Steroid Biochem. Mol. Biol. pmid:15862963
Germann M et al. Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. 2005 J. Biol. Chem. pmid:16120615
Müllner H et al. YEH2/YLR020c encodes a novel steryl ester hydrolase of the yeast Saccharomyces cerevisiae. 2005 J. Biol. Chem. pmid:15632184
Almaas E et al. The activity reaction core and plasticity of metabolic networks. 2005 PLoS Comput. Biol. pmid:16362071
Liu Y et al. Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells. 2005 Mol. Endocrinol. pmid:15761033
Javitt NB Oxysteroids: a new class of steroids with autocrine and paracrine functions. 2004 Trends Endocrinol. Metab. pmid:15380811
Duarte NC et al. Integrated analysis of metabolic phenotypes in Saccharomyces cerevisiae. 2004 BMC Genomics pmid:15355549
Kaneshiro ES Sterol metabolism in the opportunistic pathogen Pneumocystis: advances and new insights. 2004 Lipids pmid:15638243
Kanagasabai R et al. Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain. 2004 Lipids pmid:15638241
Suárez Y et al. Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. 2004 Cardiovasc. Res. pmid:15485695
Mo C et al. The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p). 2004 Biochim. Biophys. Acta pmid:15522820
Zhou W and Nes WD Sterol methyltransferase2: purification, properties, and inhibition. 2003 Arch. Biochem. Biophys. pmid:14622971
Berthois Y et al. SR31747A is a sigma receptor ligand exhibiting antitumoural activity both in vitro and in vivo. 2003 Br. J. Cancer pmid:12569389
Marijanovic Z et al. Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. 2003 Mol. Endocrinol. pmid:12829805
Veen M et al. Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. 2003 FEMS Yeast Res. pmid:14554200
Pikuleva I and Javitt NB Novel sterols synthesized via the CYP27A1 metabolic pathway. 2003 Arch. Biochem. Biophys. pmid:14622972
Lusa S et al. Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. 2003 J. Biol. Chem. pmid:12657643
Nes WD et al. Active site mapping and substrate channeling in the sterol methyltransferase pathway. 2002 J. Biol. Chem. pmid:12196515
Nes WD et al. Purification, characterization and catalytic properties of human sterol 8-isomerase. 2002 Biochem. J. pmid:12133002
Chevy F et al. Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis. 2002 J. Lipid Res. pmid:12177163
Swain E et al. Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. 2002 J. Biol. Chem. pmid:12006573
Kaneshiro ES et al. The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference. 2002 Mol. Microbiol. pmid:12010494
Baudry K et al. The effect of the erg26-1 mutation on the regulation of lipid metabolism in Saccharomyces cerevisiae. 2001 J. Biol. Chem. pmid:11279045
Soustre I et al. Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae. 2000 FEBS Lett. pmid:10734216
Nes WD et al. Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae. 1997 Arch. Biochem. Biophys. pmid:9185615
Acuna-Johnson AP et al. Stereochemistry of yeast delta 24-sterol methyl transferase. 1997 Bioorg. Med. Chem. pmid:9208094
Urbina JA et al. Modification of the sterol composition of Trypanosoma (Schizotrypanum) cruzi epimastigotes by delta 24(25)-sterol methyl transferase inhibitors and their combinations with ketoconazole. 1995 Mol. Biochem. Parasitol. pmid:8577328
Lange Y Cholesterol movement from plasma membrane to rough endoplasmic reticulum. Inhibition by progesterone. 1994 J. Biol. Chem. pmid:8106380
Lange Y et al. Movement of zymosterol, a precursor of cholesterol, among three membranes in human fibroblasts. 1991 J. Biol. Chem. pmid:1939176
Echevarria F et al. Zymosterol is located in the plasma membrane of cultured human fibroblasts. 1990 J. Biol. Chem. pmid:2341392
Chen JK et al. Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. 1986 Exp. Cell Res. pmid:3943557
Nakanishi S et al. Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. 1984 J. Biochem. pmid:6397465
Pereira R et al. The effect of AY-9944 on yeast sterol and sterol ester metabolism. 1983 Lipids pmid:6194399
Huijmans JG et al. Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. 1981 Acta Endocrinol. pmid:6263029
Taylor UF et al. Sterol synthesis: a simple method for the isolation of zymosterol (5 alpha-cholesta-8, 24-dien-3 beta-ol) from yeast and spectral properties of zymosterol. 1981 J. Lipid Res. pmid:7012256
Nishino T et al. Subcellular localization of the enzymes involved in the late stage of ergosterol biosynthesis in yeast. 1981 J. Biochem. pmid:7024258
SCHROEPFER GJ Conversion of zymosterol-C-14 and zymostenol-H3 to cholesterol by rat liver homogenates and intact rats. 1961 J. Biol. Chem. pmid:13748688
ALEXANDER GJ and SCHWENK E Studies on biosynthesis of cholesterol. IX. Zymosterol as a precursor of cholesterol. 1957 Arch. Biochem. Biophys. pmid:13403684
pmid: