| MeSH term | MeSH ID | Detail |
|---|---|---|
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Total
1
Zymosterol
Zymosterol is a lipid of Sterol Lipids (ST) class. Zymosterol is associated with abnormalities such as Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease and Virus Diseases. The involved functions are known as Process, enzyme activity, Anabolism, Transcription, Genetic and Synthesis. Zymosterol often locates in Cytosol, Mitochondria, Articular system, Protoplasm and Tissue membrane. The associated genes with Zymosterol are Genome, Homologous Gene, Amino Acids, Acidic, Peptide Fragments and DLC1 gene. The related lipids are zymosterol, Cardiolipins, 25-azacholesterol, Sterols and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Zymosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Zymosterol?
Zymosterol is suspected in Leishmaniasis, Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Zymosterol
PubChem Associated disorders and diseases
What pathways are associated with Zymosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Zymosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Zymosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Zymosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Zymosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Zymosterol?
Knock-out
Knock-out are used in the study 'Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major.' (Chavali AK et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Zymosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Acuna-Johnson AP et al. | Stereochemistry of yeast delta 24-sterol methyl transferase. | 1997 | Bioorg. Med. Chem. | pmid:9208094 |
| Nes WD et al. | Substrate-based inhibitors of the (S)-adenosyl-L-methionine:delta24(25)- to delta24(28)-sterol methyl transferase from Saccharomyces cerevisiae. | 1997 | Arch. Biochem. Biophys. | pmid:9185615 |
| Urbina JA et al. | Modification of the sterol composition of Trypanosoma (Schizotrypanum) cruzi epimastigotes by delta 24(25)-sterol methyl transferase inhibitors and their combinations with ketoconazole. | 1995 | Mol. Biochem. Parasitol. | pmid:8577328 |
| Lange Y | Cholesterol movement from plasma membrane to rough endoplasmic reticulum. Inhibition by progesterone. | 1994 | J. Biol. Chem. | pmid:8106380 |
| Nishino T et al. | Subcellular localization of the enzymes involved in the late stage of ergosterol biosynthesis in yeast. | 1981 | J. Biochem. | pmid:7024258 |
| Taylor UF et al. | Sterol synthesis: a simple method for the isolation of zymosterol (5 alpha-cholesta-8, 24-dien-3 beta-ol) from yeast and spectral properties of zymosterol. | 1981 | J. Lipid Res. | pmid:7012256 |
| Nakanishi S et al. | Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. | 1984 | J. Biochem. | pmid:6397465 |
| Huijmans JG et al. | Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. | 1981 | Acta Endocrinol. | pmid:6263029 |
| Pereira R et al. | The effect of AY-9944 on yeast sterol and sterol ester metabolism. | 1983 | Lipids | pmid:6194399 |
| Chen JK et al. | Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. | 1986 | Exp. Cell Res. | pmid:3943557 |
| Qi Y et al. | Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition. | 2017 | Appl. Environ. Microbiol. | pmid:28710262 |
| HÄ…c-Wydro K et al. | The influence of cholesterol precursor--desmosterol--on artificial lipid membranes. | 2015 | Biochim. Biophys. Acta | pmid:25960185 |
| Medina JM et al. | Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine. | 2015 | Mem. Inst. Oswaldo Cruz | pmid:25742263 |
| HÄ…c-Wydro K et al. | The comparison of zymosterol vs cholesterol membrane properties--the effect of zymosterol on lipid monolayers. | 2014 | Colloids Surf B Biointerfaces | pmid:25444659 |
| Echevarria F et al. | Zymosterol is located in the plasma membrane of cultured human fibroblasts. | 1990 | J. Biol. Chem. | pmid:2341392 |
| Sukhanova A et al. | Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. | 2013 | Cancer Discov | pmid:23125191 |
| Shin GH et al. | Overexpression of genes of the fatty acid biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. | 2012 | Yeast | pmid:22926964 |
| McDonald JG et al. | A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. | 2012 | J. Lipid Res. | pmid:22517925 |
| Kloimwieder A and Winston F | A Screen for Germination Mutants in Saccharomyces cerevisiae. | 2011 | G3 (Bethesda) | pmid:22384326 |
| Lange Y et al. | Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. | 2012 | PLoS ONE | pmid:22276143 |