| MeSH term | MeSH ID | Detail |
|---|---|---|
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Total
1
Zymosterol
Zymosterol is a lipid of Sterol Lipids (ST) class. Zymosterol is associated with abnormalities such as Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease and Virus Diseases. The involved functions are known as Process, enzyme activity, Anabolism, Transcription, Genetic and Synthesis. Zymosterol often locates in Cytosol, Mitochondria, Articular system, Protoplasm and Tissue membrane. The associated genes with Zymosterol are Genome, Homologous Gene, Amino Acids, Acidic, Peptide Fragments and DLC1 gene. The related lipids are zymosterol, Cardiolipins, 25-azacholesterol, Sterols and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Zymosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Zymosterol?
Zymosterol is suspected in Leishmaniasis, Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Zymosterol
PubChem Associated disorders and diseases
What pathways are associated with Zymosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Zymosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Zymosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Zymosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Zymosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Zymosterol?
Knock-out
Knock-out are used in the study 'Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major.' (Chavali AK et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Zymosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berthois Y et al. | SR31747A is a sigma receptor ligand exhibiting antitumoural activity both in vitro and in vivo. | 2003 | Br. J. Cancer | pmid:12569389 |
| Sukhanova A et al. | Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. | 2013 | Cancer Discov | pmid:23125191 |
| Suárez Y et al. | Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. | 2004 | Cardiovasc. Res. | pmid:15485695 |
| Nes WD | Biosynthesis of cholesterol and other sterols. | 2011 | Chem. Rev. | pmid:21902244 |
| HÄ…c-Wydro K et al. | The comparison of zymosterol vs cholesterol membrane properties--the effect of zymosterol on lipid monolayers. | 2014 | Colloids Surf B Biointerfaces | pmid:25444659 |
| Jokela H et al. | Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos. | 2010 | Endocrinology | pmid:20185768 |
| Chen JK et al. | Biochemical characterization of the cholesterol-dependent growth of the NS-1 mouse myeloma cell line. | 1986 | Exp. Cell Res. | pmid:3943557 |
| Soustre I et al. | Sterol metabolism and ERG2 gene regulation in the yeast Saccharomyces cerevisiae. | 2000 | FEBS Lett. | pmid:10734216 |
| Veen M et al. | Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae. | 2003 | FEMS Yeast Res. | pmid:14554200 |
| Kloimwieder A and Winston F | A Screen for Germination Mutants in Saccharomyces cerevisiae. | 2011 | G3 (Bethesda) | pmid:22384326 |
| Snitkin ES et al. | Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions. | 2008 | Genome Biol. | pmid:18808699 |
| de Souza W and Rodrigues JC | Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. | 2009 | Interdiscip Perspect Infect Dis | pmid:19680554 |
| Kawashima H et al. | Differences in sterol composition of gonads of the lottiid limpets Nipponacmea concinna and Nipponacmea fuscoviridis from northeastern Japan. | 2011 | J Oleo Sci | pmid:21937849 |
| Nakanishi S et al. | Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. | 1984 | J. Biochem. | pmid:6397465 |
| Nishino T et al. | Subcellular localization of the enzymes involved in the late stage of ergosterol biosynthesis in yeast. | 1981 | J. Biochem. | pmid:7024258 |
| Lange Y | Cholesterol movement from plasma membrane to rough endoplasmic reticulum. Inhibition by progesterone. | 1994 | J. Biol. Chem. | pmid:8106380 |
| Echevarria F et al. | Zymosterol is located in the plasma membrane of cultured human fibroblasts. | 1990 | J. Biol. Chem. | pmid:2341392 |
| Baudry K et al. | The effect of the erg26-1 mutation on the regulation of lipid metabolism in Saccharomyces cerevisiae. | 2001 | J. Biol. Chem. | pmid:11279045 |
| Swain E et al. | Sterol-dependent regulation of sphingolipid metabolism in Saccharomyces cerevisiae. | 2002 | J. Biol. Chem. | pmid:12006573 |
| Lange Y et al. | Movement of zymosterol, a precursor of cholesterol, among three membranes in human fibroblasts. | 1991 | J. Biol. Chem. | pmid:1939176 |