| MeSH term | MeSH ID | Detail |
|---|---|---|
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Total
1
Zymosterol
Zymosterol is a lipid of Sterol Lipids (ST) class. Zymosterol is associated with abnormalities such as Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease and Virus Diseases. The involved functions are known as Process, enzyme activity, Anabolism, Transcription, Genetic and Synthesis. Zymosterol often locates in Cytosol, Mitochondria, Articular system, Protoplasm and Tissue membrane. The associated genes with Zymosterol are Genome, Homologous Gene, Amino Acids, Acidic, Peptide Fragments and DLC1 gene. The related lipids are zymosterol, Cardiolipins, 25-azacholesterol, Sterols and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of Zymosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Zymosterol?
Zymosterol is suspected in Leishmaniasis, Congenital Abnormality, Coronary Arteriosclerosis, Liver diseases, Alzheimer's Disease, Virus Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Zymosterol
PubChem Associated disorders and diseases
What pathways are associated with Zymosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Zymosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Zymosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Zymosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Zymosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Zymosterol?
Knock-out
Knock-out are used in the study 'Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major.' (Chavali AK et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Zymosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Germann M et al. | Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. | 2005 | J. Biol. Chem. | pmid:16120615 |
| Müllner H et al. | YEH2/YLR020c encodes a novel steryl ester hydrolase of the yeast Saccharomyces cerevisiae. | 2005 | J. Biol. Chem. | pmid:15632184 |
| Echevarria F et al. | Zymosterol is located in the plasma membrane of cultured human fibroblasts. | 1990 | J. Biol. Chem. | pmid:2341392 |
| Megha O et al. | Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. | 2006 | J. Biol. Chem. | pmid:16735517 |
| Yang C et al. | Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. | 2006 | J. Biol. Chem. | pmid:16857673 |
| Zhou W et al. | Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei. | 2006 | J. Biol. Chem. | pmid:16414960 |
| SCHROEPFER GJ | Conversion of zymosterol-C-14 and zymostenol-H3 to cholesterol by rat liver homogenates and intact rats. | 1961 | J. Biol. Chem. | pmid:13748688 |
| Lusa S et al. | Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells. | 2003 | J. Biol. Chem. | pmid:12657643 |
| Acimovic J et al. | Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19525158 |
| Chevy F et al. | Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis. | 2002 | J. Lipid Res. | pmid:12177163 |
| McDonald JG et al. | A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. | 2012 | J. Lipid Res. | pmid:22517925 |
| Taylor UF et al. | Sterol synthesis: a simple method for the isolation of zymosterol (5 alpha-cholesta-8, 24-dien-3 beta-ol) from yeast and spectral properties of zymosterol. | 1981 | J. Lipid Res. | pmid:7012256 |
| Liu H et al. | Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15862963 |
| Fon Tacer K et al. | Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206258 |
| Kawashima H et al. | Differences in sterol composition between male and female gonads of dominant limpet species. | 2009 | Lipids | pmid:19452182 |
| Pereira R et al. | The effect of AY-9944 on yeast sterol and sterol ester metabolism. | 1983 | Lipids | pmid:6194399 |
| Kaneshiro ES | Sterol metabolism in the opportunistic pathogen Pneumocystis: advances and new insights. | 2004 | Lipids | pmid:15638243 |
| Kanagasabai R et al. | Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain. | 2004 | Lipids | pmid:15638241 |
| Medina JM et al. | Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine. | 2015 | Mem. Inst. Oswaldo Cruz | pmid:25742263 |
| Chemler JA et al. | Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae. | 2006 | Microb. Cell Fact. | pmid:16719921 |