MeSH term | MeSH ID | Detail |
---|---|---|
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Hemolysis | D006461 | 131 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lu L et al. | Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans. | 2012 | Hum. Genet. | pmid:21972121 |
Al-Owain M et al. | Smith-Lemli-Opitz syndrome among Arabs. | 2012 | Clin. Genet. | pmid:21696385 |
Chagas CE et al. | Focus on vitamin D, inflammation and type 2 diabetes. | 2012 | Nutrients | pmid:22347618 |
Chesney RW | Theobald palm and his remarkable observation: how the sunshine vitamin came to be recognized. | 2012 | Nutrients | pmid:22347617 |
Jones AP et al. | Vitamin D and allergic disease: sunlight at the end of the tunnel? | 2012 | Nutrients | pmid:22347615 |
Godar DE et al. | Solar UV doses of young Americans and vitamin D3 production. | 2012 | Environ. Health Perspect. | pmid:21852226 |
Shackleton CH | Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesis. | 2012 | Lipids | pmid:21874273 |
Roullet JB et al. | No evidence for mevalonate shunting in moderately affected children with Smith-Lemli-Opitz syndrome. | 2012 | J. Inherit. Metab. Dis. | pmid:22391996 |
Lim L et al. | Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease. | 2012 | Cell Death Differ. | pmid:21818119 |
Tuckey RC et al. | Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol. | 2012 | Drug Metab. Dispos. | pmid:22106170 |