MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Schmidt DA et al. | Quantifying the vitamin D3 synthesizing potential of UVB lamps at specific distances over time. | 2010 Nov-Dec | Zoo Biol. | pmid:20839282 |
Oberthür A et al. | [Smith-Lemli-Opitz syndrome--case report, diagnostics and therapeutic options]. | 2009 | Z Geburtshilfe Neonatol | pmid:19856245 |
Ko HS et al. | Prenatal diagnosis of congenital lipoid adrenal hyperplasia (CLAH) by molecular genetic testing in Korean siblings. | 2011 | Yonsei Med. J. | pmid:22028173 |
Lu ZR et al. | [Preparation of milligram quantity of vitamin D3 isomers by a two-step high performance liquid chromatographic method]. | 1992 | Yao Xue Xue Bao | pmid:1332420 |
Radonovich LJ et al. | Influenza and ultraviolet germicidal irradiation. | 2008 | Virol. J. | pmid:19087288 |
How KL et al. | Photosynthesis of vitamin D3 in cats. | 1994 | Vet. Rec. | pmid:8009805 |
Thiem U et al. | VITA-D: cholecalciferol substitution in vitamin D deficient kidney transplant recipients: a randomized, placebo-controlled study to evaluate the post-transplant outcome. | 2009 | Trials | pmid:19480654 |
Holick MF et al. | Physiologic implications of the formation of previtamin D3 in skin. | 1979 | Trans. Assoc. Am. Physicians | pmid:232946 |
Sunyecz JA | The use of calcium and vitamin D in the management of osteoporosis. | 2008 | Ther Clin Risk Manag | pmid:19209265 |
Repetto M et al. | Teratogenic effect of the cholesterol synthesis inhibitor AY 9944 on rat embryos in vitro. | 1990 | Teratology | pmid:1708171 |