7-Dehydrocholesterol

7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 7-Dehydrocholesterol?

7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Smith-Lemli-Opitz Syndrome D019082 7 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with 7-Dehydrocholesterol

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 7-Dehydrocholesterol?

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Location Cross reference Weighted score Related literatures
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What functions are associated with 7-Dehydrocholesterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with 7-Dehydrocholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 7-Dehydrocholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 7-Dehydrocholesterol?

Mouse Model

Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).

Knock-out

Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).

Rodent Model

Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 7-Dehydrocholesterol

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Authors Title Published Journal PubMed Link
Ciara E et al. SLOS carrier frequency in Poland as determined by screening for Trp151X and Val326Leu DHCR7 mutations. Eur J Med Genet pmid:16497572
pmid:
GREEN J Studies on the analysis of vitamins D. 4. Studies on the irradiation of ergosterol and 7-dehydrocholesterol and the analysis of the products for calciferol, vitamin D3, and component sterols. 1951 Biochem. J. pmid:14858317
GLOVER M et al. Provitamin D3 in tissues and the conversion of cholesterol to 7-dehydrocholesterol in vivo. 1952 Biochem. J. pmid:14944524
MOORE T and WARD RJ 7-Dehydrocholesterol in the sexual organs of the rat. 1952 Biochem. J. pmid:13018188
WELLS WW et al. Intestinal sterols. I. Delta7-cholestenol and 7-dehydrocholesterol in feces. 1955 Arch. Biochem. Biophys. pmid:13259659
GLOVER J and STAINER DW Sterol metabolism. 4. The absorption of 7-dehydrocholesterol in the rat. 1959 Biochem. J. pmid:13651139
MERCER EI and GLOVER J Sterol metabolism. 6. The interconversion of cholesterol, 7-dehydrocholesterol and lathosterol in the rat. 1961 Biochem. J. pmid:13769547
JEFFERSON WE and SISCO G The influence of exogenous steroids on the growth of Aspergillus niger and Torula ***lis. 1961 J. Gen. Physiol. pmid:13789749
KANDUTSCH AA Enzymatic reduction of the delta7 bond of 7-dehydrocholesterol. 1962 J. Biol. Chem. pmid:14453564