| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Total
4
7-Dehydrocholesterol
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 7-Dehydrocholesterol?
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
PubChem Associated disorders and diseases
What pathways are associated with 7-Dehydrocholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 7-Dehydrocholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 7-Dehydrocholesterol?
Mouse Model
Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 7-Dehydrocholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang Y et al. | A simple and precise method to detect sterol esterification activity of lecithin/cholesterol acyltransferase by high-performance liquid chromatography. | 2018 | Anal Bioanal Chem | pmid:29307006 |
| Kurogi K et al. | Sulfation of vitamin D -related compounds-identification and characterization of the responsible human cytosolic sulfotransferases. | 2017 | FEBS Lett. | pmid:28746983 |
| Sharif NF et al. | Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome. | 2017 | Genes Brain Behav. | pmid:28220990 |
| Huang SS et al. | 7-Dehydrocholesterol (7-DHC), But Not Cholesterol, Causes Suppression of Canonical TGF-β Signaling and Is Likely Involved in the Development of Atherosclerotic Cardiovascular Disease (ASCVD). | 2017 | J. Cell. Biochem. | pmid:27862220 |
| Vasilevskaya AV et al. | Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27289046 |
| Miller WL | Genetic disorders of Vitamin D biosynthesis and degradation. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27060335 |
| Endo-Umeda K et al. | 1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28736297 |
| Özçelik R et al. | Prepartum daylight exposure increases serum calcium concentrations in dairy cows at the onset of lactation. | 2017 | J. Anim. Sci. | pmid:29108038 |
| Travessa A et al. | Prenatal diagnosis of holoprosencephaly associated with Smith-Lemli-Opitz syndrome (SLOS) in a 46,XX fetus. | 2017 | Taiwan J Obstet Gynecol | pmid:28805615 |
| Korade Ž et al. | Effect of psychotropic drug treatment on sterol metabolism. | 2017 | Schizophr. Res. | pmid:28202290 |
| Griffiths WJ et al. | Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26976653 |
| Movassaghi M et al. | Vitamin D levels in Smith-Lemli-Opitz syndrome. | 2017 | Am. J. Med. Genet. A | pmid:28796426 |
| Wassif CA et al. | A placebo-controlled trial of simvastatin therapy in Smith-Lemli-Opitz syndrome. | 2017 | Genet. Med. | pmid:27513191 |
| Satué M et al. | Titanium implants coated with UV-irradiated vitamin D precursor and vitamin E: in vivo performance and coating stability. | 2017 | Clin Oral Implants Res | pmid:26926140 |
| Ehrhardt M et al. | Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. | 2016 | J. Biotechnol. | pmid:26638999 |
| Kim HY et al. | Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells. | 2016 | Chem. Res. Toxicol. | pmid:27097157 |
| Prabhu AV et al. | DHCR7: A vital enzyme switch between cholesterol and vitamin D production. | 2016 | Prog. Lipid Res. | pmid:27697512 |
| Balajthy A et al. | 7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome. | 2016 | Pflugers Arch. | pmid:27315086 |
| Tsukagoshi Y et al. | Functional characterization of CYP71D443, a cytochrome P450 catalyzing C-22 hydroxylation in the 20-hydroxyecdysone biosynthesis of Ajuga hairy roots. | 2016 | Phytochemistry | pmid:27017303 |
| Grigalavicius M et al. | Layer Thickness of SPF 30 Sunscreen and Formation of Pre-vitamin D. | 2016 | Anticancer Res. | pmid:26977044 |
| Staneva G et al. | Metabolic Precursor of Cholesterol Causes Formation of Chained Aggregates of Liquid-Ordered Domains. | 2016 | Langmuir | pmid:26783730 |
| Kühn J et al. | Oral intake of 7-dehydrocholesterol increases vitamin D concentrations in the liver and kidney. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26709139 |
| Satué M et al. | UV-activated 7-dehydrocholesterol-coated titanium implants promote differentiation of human umbilical cord mesenchymal stem cells into osteoblasts. | 2016 | J Biomater Appl | pmid:25899927 |
| Satué M et al. | Improved human gingival fibroblast response to titanium implants coated with ultraviolet-irradiated vitamin D precursor and vitamin E. | 2016 | J. Periodont. Res. | pmid:26271967 |
| Sever N et al. | Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27162362 |
| Francis KR et al. | Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/β-catenin defects in neuronal cholesterol synthesis phenotypes. | 2016 | Nat. Med. | pmid:26998835 |
| Prabhu AV et al. | Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis. | 2016 | J. Biol. Chem. | pmid:26887953 |
| Pfeffer BA et al. | Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density. | 2016 | Exp. Eye Res. | pmid:26854824 |
| Korade Z et al. | The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts. | 2016 | J. Med. Chem. | pmid:26789657 |
| Blassberg R et al. | Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome. | 2016 | Hum. Mol. Genet. | pmid:26685159 |
| Gou-FÃ bregas M et al. | 7-dehydrocholesterol efficiently supports Ret signaling in a mouse model of Smith-Opitz-Lemli syndrome. | 2016 | Sci Rep | pmid:27334845 |
| Benesch MG et al. | A calorimetric and spectroscopic comparison of the effects of cholesterol and its immediate biosynthetic precursors 7-dehydrocholesterol and desmosterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. | 2015 | Chem. Phys. Lipids | pmid:26368000 |
| Koczok K et al. | [Inborn error of cholesterol biosynthesis: Smith-Lemli-Opitz syndrome]. | 2015 | Orv Hetil | pmid:26551309 |
| Becker S et al. | LC-MS/MS-based quantification of cholesterol and related metabolites in dried blood for the screening of inborn errors of sterol metabolism. | 2015 | Anal Bioanal Chem | pmid:25963649 |
| Enya S et al. | The silkworm glutathione S-transferase gene noppera-bo is required for ecdysteroid biosynthesis and larval development. | 2015 | Insect Biochem. Mol. Biol. | pmid:25881968 |
| Radtke J et al. | Isolated Conglutin γ from Lupin, but not Phytate, Lowers Serum Cholesterol Without Influencing Vascular Lesion Development in the ApoE-deficient Mouse Model. | 2015 | Plant Foods Hum Nutr | pmid:25814378 |
| Poklepovich TJ et al. | Expression and functional characterization of a C-7 cholesterol desaturase from Tetrahymena thermophila in an insect cell line. | 2015 | Steroids | pmid:25681633 |
| Satué M et al. | Cholecalciferol synthesized after UV-activation of 7-dehydrocholesterol onto titanium implants inhibits osteoclastogenesis in vitro. | 2015 | J Biomed Mater Res A | pmid:25369149 |
| Pierens SL and Fraser DR | The origin and metabolism of vitamin D in rainbow trout. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25305412 |
| Lanthaler B et al. | Characterization of large deletions in the DHCR7 gene. | 2015 | Clin. Genet. | pmid:25040602 |
| Slominski AT et al. | Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland. | 2015 | Sci Rep | pmid:26445902 |
| Xue Y et al. | Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism. | 2015 | J. Invest. Dermatol. | pmid:26214382 |
| Su W et al. | Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae. | 2015 | PLoS ONE | pmid:26098102 |
| Xu L et al. | Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI. | 2015 | J. Am. Soc. Mass Spectrom. | pmid:25822928 |
| Slominski AT et al. | Novel activities of CYP11A1 and their potential physiological significance. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25448732 |
| Muchalski H et al. | Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol. | 2015 | Org. Biomol. Chem. | pmid:25435103 |
| Endo-Umeda K et al. | 7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity. | 2014 | J. Steroid Biochem. Mol. Biol. | pmid:24269243 |
| Clausen DN et al. | Development of molecularly imprinted poly(methacrylic acid)/silica for clean-up and selective extraction of cholesterol in milk prior to analysis by HPLC-UV. | 2014 | Analyst | pmid:25068793 |
| Gelzo M et al. | Evaluation of cytotoxic effects of 7-dehydrocholesterol on melanoma cells. | 2014 | Free Radic. Biol. Med. | pmid:24561580 |
| Rosecrans R and Dohnal JC | Seasonal vitamin D changes and the impact on health risk assessment. | 2014 | Clin. Biochem. | pmid:24525255 |
| Bzdúch V et al. | [Historical aspects of the Smith-Lemli-Opitz syndrome]. | 2014 | Cas. Lek. Cesk. | pmid:24506692 |
| Goyal S et al. | Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. | 2014 | J. Lipid Res. | pmid:25017465 |
| Merkens MJ et al. | Feeding impairments associated with plasma sterols in Smith-Lemli-Opitz syndrome. | 2014 | J. Pediatr. | pmid:25039049 |
| Xu L and Porter NA | Reactivities and products of free radical oxidation of cholestadienols. | 2014 | J. Am. Chem. Soc. | pmid:24625033 |
| Björkhem I et al. | On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO. | 2014 | J. Lipid Res. | pmid:24771866 |
| Ganmaa D et al. | Vitamin D deficiency in reproductive age Mongolian women: a cross sectional study. | 2014 | J. Steroid Biochem. Mol. Biol. | pmid:24076033 |
| Holick MF | Sunlight, ultraviolet radiation, vitamin D and skin cancer: how much sunlight do we need? | 2014 | Adv. Exp. Med. Biol. | pmid:25207357 |
| Liu W et al. | A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. | 2014 | J. Lipid Res. | pmid:24259532 |
| Hall P et al. | Aripiprazole and trazodone cause elevations of 7-dehydrocholesterol in the absence of Smith-Lemli-Opitz Syndrome. | 2013 Sep-Oct | Mol. Genet. Metab. | pmid:23628460 |
| Kawamoto H et al. | An efficient synthesis of 4α- and 4β-hydroxy- 7-dehydrocholesterol, biomarkers for patients with and animal models of the Smith-Lemli-Opitz syndrome. | 2013 Oct-Nov | Chem. Phys. Lipids | pmid:23920082 |
| Arruda BC et al. | Photochemical ring-opening and ground state relaxation in α-terpinene with comparison to provitamin D3. | 2013 | J Phys Chem B | pmid:23387423 |
| Singh P et al. | Differential effect of sterols on dipole potential in hippocampal membranes: implications for receptor function. | 2013 | Biochim. Biophys. Acta | pmid:23201544 |
| Keller RK et al. | Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz Syndrome. | 2013 | Lipids | pmid:23361583 |
| Dixon KM et al. | Vitamin D and death by sunshine. | 2013 | Int J Mol Sci | pmid:23334476 |
| Korade Z et al. | Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome. | 2013 | J. Inherit. Metab. Dis. | pmid:22718275 |
| Porter NA | A perspective on free radical autoxidation: the physical organic chemistry of polyunsaturated fatty acid and sterol peroxidation. | 2013 | J. Org. Chem. | pmid:23445181 |
| Rajeev R and Sunoj RB | Mechanism and stereoselectivity of biologically important oxygenation reactions of the 7-dehydrocholesterol radical. | 2013 | J. Org. Chem. | pmid:23829766 |
| Kuan V et al. | DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudes. | 2013 | BMC Evol. Biol. | pmid:23837623 |
| Windsor K et al. | Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome. | 2013 | J. Lipid Res. | pmid:23828810 |
| Satué M et al. | UV photoactivation of 7-dehydrocholesterol on titanium implants enhances osteoblast differentiation and decreases Rankl gene expression. | 2013 | Acta Biomater | pmid:23201015 |
| Xu L et al. | Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells. | 2013 | J. Lipid Res. | pmid:23381570 |
| Shimomura H et al. | Detoxification of 7-dehydrocholesterol fatal to Helicobacter pylori is a novel role of cholesterol glucosylation. | 2013 | J. Bacteriol. | pmid:23144252 |
| Satué M et al. | UV-irradiated 7-dehydrocholesterol coating on polystyrene surfaces is converted to active vitamin D by osteoblastic MC3T3-E1 cells. | 2013 | Photochem. Photobiol. Sci. | pmid:23538933 |
| Pondeville E et al. | Microarray and RNAi analysis of P450s in Anopheles gambiae male and female steroidogenic tissues: CYP307A1 is required for ecdysteroid synthesis. | 2013 | PLoS ONE | pmid:24324583 |
| Kohler M et al. | Influence of altitude on vitamin D and bone metabolism of lactating sheep and goats. | 2013 | J. Anim. Sci. | pmid:24045489 |
| Desotelle JA et al. | The circadian control of skin and cutaneous photodamage. | 2012 Sep-Oct | Photochem. Photobiol. | pmid:22277067 |
| Radlović N et al. | Vitamin D in the light of current knowledge. | 2012 Jan-Feb | Srp Arh Celok Lek | pmid:22462359 |
| Haldar S et al. | Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential. | 2012 | Biophys. J. | pmid:22500756 |
| Alloza I et al. | ANKRD55 and DHCR7 are novel multiple sclerosis risk loci. | 2012 | Genes Immun. | pmid:22130326 |
| Laaksi I | Vitamin D and respiratory infection in adults. | 2012 | Proc Nutr Soc | pmid:22115013 |
| Lu L et al. | Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans. | 2012 | Hum. Genet. | pmid:21972121 |
| Al-Owain M et al. | Smith-Lemli-Opitz syndrome among Arabs. | 2012 | Clin. Genet. | pmid:21696385 |
| Voruganti VS et al. | Variants in CPT1A, FADS1, and FADS2 are Associated with Higher Levels of Estimated Plasma and Erythrocyte Delta-5 Desaturases in Alaskan Eskimos. | 2012 | Front Genet | pmid:22701466 |
| Park HY et al. | Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis. | 2012 | J. Korean Med. Sci. | pmid:22690097 |
| Wagner CL et al. | Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus. | 2012 | Nutrients | pmid:22666547 |
| Shaygannejad V et al. | Effects of adjunct low-dose vitamin d on relapsing-remitting multiple sclerosis progression: preliminary findings of a randomized placebo-controlled trial. | 2012 | Mult Scler Int | pmid:22567287 |
| Zhao G et al. | Factors Associated with Vitamin D Deficiency and Inadequacy among Women of Childbearing Age in the United States. | 2012 | ISRN Obstet Gynecol | pmid:22523695 |
| Reilly L et al. | Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium. | 2012 | J Parasitol Res | pmid:22523639 |
| Schwalfenberg GK | Solar radiation and vitamin D: mitigating environmental factors in autoimmune disease. | 2012 | J Environ Public Health | pmid:22523507 |
| Lee SS and Schroeder FC | Steroids as central regulators of organismal development and lifespan. | 2012 | PLoS Biol. | pmid:22505849 |
| Theodoratou E et al. | Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis. | 2012 | PLoS ONE | pmid:22701574 |
| Panicker SP et al. | Sterol intermediates of cholesterol biosynthesis inhibit hair growth and trigger an innate immune response in cicatricial alopecia. | 2012 | PLoS ONE | pmid:22685570 |
| Wollam J et al. | A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. | 2012 | PLoS Biol. | pmid:22505847 |
| Chakraborty A et al. | Long term induction by pterostilbene results in autophagy and cellular differentiation in MCF-7 cells via ROS dependent pathway. | 2012 | Mol. Cell. Endocrinol. | pmid:22273805 |
| Slominski AT et al. | Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes. | 2012 | Int. J. Biochem. Cell Biol. | pmid:22877869 |
| Lang M et al. | Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species. | 2012 | Science | pmid:23019649 |
| Desai NS et al. | Effects of sunlight and diet on vitamin D status of pulmonary tuberculosis patients in Tbilisi, Georgia. | 2012 | Nutrition | pmid:22304856 |
| Xu L et al. | DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model. | 2012 | Neurobiol. Dis. | pmid:22182693 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |
| Förster F et al. | Transcriptome analysis in tardigrade species reveals specific molecular pathways for stress adaptations. | 2012 | Bioinform Biol Insights | pmid:22563243 |