| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Total
4
7-Dehydrocholesterol
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 7-Dehydrocholesterol?
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
PubChem Associated disorders and diseases
What pathways are associated with 7-Dehydrocholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 7-Dehydrocholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 7-Dehydrocholesterol?
Mouse Model
Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 7-Dehydrocholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Gaoua W et al. | Oxidized derivatives of 7-dehydrocholesterol induce growth retardation in cultured rat embryos: a model for antenatal growth retardation in the Smith-Lemli-Opitz syndrome. | 1999 | J. Lipid Res. | pmid:10064734 |
| Kratz LE and Kelley RI | Prenatal diagnosis of the RSH/Smith-Lemli-Opitz syndrome. | 1999 | Am. J. Med. Genet. | pmid:10069707 |
| Andersson HC et al. | Adrenal insufficiency in Smith-Lemli-Opitz syndrome. | 1999 | Am. J. Med. Genet. | pmid:10069708 |
| Bick DP et al. | Prenatal diagnosis of Smith-Lemli-Opitz syndrome in a pregnancy with low maternal serum oestriol and a sex-reversed fetus. | 1999 | Prenat. Diagn. | pmid:10073912 |
| Fliesler SJ et al. | Marked alteration of sterol metabolism and composition without compromising retinal development or function. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10393050 |
| Neklason DW et al. | Biochemical variants of Smith-Lemli-Opitz syndrome. | 1999 | Am. J. Med. Genet. | pmid:10405455 |
| Honda A et al. | Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver. | 1999 | J. Lipid Res. | pmid:10428990 |
| Anstey AV et al. | Characterization of photosensitivity in the Smith-Lemli-Opitz syndrome: a new congenital photosensitivity syndrome. | 1999 | Br. J. Dermatol. | pmid:10583043 |
| Rizzo C et al. | A simple and rapid HPLC method for simultaneous determination of plasma 7-dehydrocholesterol and vitamin E: its application in Smith-Lemli-Opitz patients. | 2000 | Clin. Chim. Acta | pmid:10612721 |
| Papadimou E et al. | Modulation of ribonuclease P activity by calcipotriol. | 2000 | Eur. J. Biochem. | pmid:10672028 |
| Nowaczyk MJ | Plasma measurement of 7-dehydrocholesterol to detect carriers of Smith-Lemli-Opitz syndrome. | 2000 | Prenat. Diagn. | pmid:10694693 |
| Linck LM et al. | Fetal demise with Smith-Lemli-Opitz syndrome confirmed by tissue sterol analysis and the absence of measurable 7-dehydrocholesterol Delta(7)-reductase activity in chorionic villi. | 2000 | Prenat. Diagn. | pmid:10719329 |
| Gaoua W et al. | Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model. | 2000 | J. Lipid Res. | pmid:10744785 |
| Obi-Tabot ET et al. | A human skin equivalent model that mimics the photoproduction of vitamin D3 in human skin. | 2000 | In Vitro Cell. Dev. Biol. Anim. | pmid:10777061 |
| Roux C et al. | Role of cholesterol in embryonic development. | 2000 | Am. J. Clin. Nutr. | pmid:10799401 |
| Wolf C and Chachaty C | Compared effects of cholesterol and 7-dehydrocholesterol on sphingomyelin-glycerophospholipid bilayers studied by ESR. | 2000 | Biophys. Chem. | pmid:10852314 |
| Diener AC et al. | Sterol methyltransferase 1 controls the level of cholesterol in plants. | 2000 | Plant Cell | pmid:10852933 |
| Chen TC et al. | An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. | 2000 | J. Nutr. Biochem. | pmid:10876100 |
| Jira PE et al. | Simvastatin. A new therapeutic approach for Smith-Lemli-Opitz syndrome. | 2000 | J. Lipid Res. | pmid:10946022 |