MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ciara E et al. | SLOS carrier frequency in Poland as determined by screening for Trp151X and Val326Leu DHCR7 mutations. | Eur J Med Genet | pmid:16497572 | |
pmid: | ||||
GREEN J | Studies on the analysis of vitamins D. 4. Studies on the irradiation of ergosterol and 7-dehydrocholesterol and the analysis of the products for calciferol, vitamin D3, and component sterols. | 1951 | Biochem. J. | pmid:14858317 |
GLOVER M et al. | Provitamin D3 in tissues and the conversion of cholesterol to 7-dehydrocholesterol in vivo. | 1952 | Biochem. J. | pmid:14944524 |
MOORE T and WARD RJ | 7-Dehydrocholesterol in the sexual organs of the rat. | 1952 | Biochem. J. | pmid:13018188 |
WELLS WW et al. | Intestinal sterols. I. Delta7-cholestenol and 7-dehydrocholesterol in feces. | 1955 | Arch. Biochem. Biophys. | pmid:13259659 |
GLOVER J and STAINER DW | Sterol metabolism. 4. The absorption of 7-dehydrocholesterol in the rat. | 1959 | Biochem. J. | pmid:13651139 |
MERCER EI and GLOVER J | Sterol metabolism. 6. The interconversion of cholesterol, 7-dehydrocholesterol and lathosterol in the rat. | 1961 | Biochem. J. | pmid:13769547 |
JEFFERSON WE and SISCO G | The influence of exogenous steroids on the growth of Aspergillus niger and Torula ***lis. | 1961 | J. Gen. Physiol. | pmid:13789749 |
KANDUTSCH AA | Enzymatic reduction of the delta7 bond of 7-dehydrocholesterol. | 1962 | J. Biol. Chem. | pmid:14453564 |
Van Cantfort J and Gielen J | Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro. | 1975 | Eur. J. Biochem. | pmid:1175606 |
Ramsey RB and Fischer VW | Effects of trans-clomiphene in combination with AY-9944 on rat CNS morphology and biochemistry. | 1976 | Acta Neuropathol. | pmid:61699 |
Ayanoglu E et al. | Minor and trace sterols in marine invertebrates V. Isolation, structure elucidation and synthesis of 3beta-hydroxy-26,27-bisnorcholest-5-en-24-one from the sponge Psammaplysilla purpurea. | 1978 | Steroids | pmid:694970 |
Holick MF et al. | Physiologic implications of the formation of previtamin D3 in skin. | 1979 | Trans. Assoc. Am. Physicians | pmid:232946 |
Norris DM and Moore CL | Lack of dietary delta 7-sterol markedly shortens the periods of locomotor vigor, reproduction and longevity of adult female Xyleborus ferrugineus (Coleoptera, Scolytidae). | 1980 | Exp. Gerontol. | pmid:7428856 |
Esvelt RP et al. | 1,25-Dihydroxyvitamin D3 stimulated increase of 7,8-didehydrocholesterol levels in rat skin. | 1980 | Biochemistry | pmid:6894095 |
Takada K et al. | Determination of 7-dehydrocholesterol in rat skin and liver by high-performance liquid chromatography. | 1981 | J. Chromatogr. | pmid:7320109 |
Takada K et al. | Application of high-performance liquid chromatography to the study of esterified 7-dehydrocholesterol in rat skin. | 1981 | Biochim. Biophys. Acta | pmid:7326246 |
Trinder P | Oxidase determination of plasma cholesterol as cholest-4-en-3-one using iso-octane extraction. | 1981 | Ann. Clin. Biochem. | pmid:6942786 |
Maziere JC et al. | Inhibition of human fibroblasts sphingomyelinase by cholesterol and 7-dehydrocholesterol. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6268086 |