MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hemolysis | D006461 | 131 associated lipids |
Abnormalities, Multiple | D000015 | 13 associated lipids |
Intellectual Disability | D008607 | 13 associated lipids |
Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lanthaler B et al. | Characterization of large deletions in the DHCR7 gene. | 2015 | Clin. Genet. | pmid:25040602 |
Xue Y et al. | Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism. | 2015 | J. Invest. Dermatol. | pmid:26214382 |
Su W et al. | Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae. | 2015 | PLoS ONE | pmid:26098102 |
Xu L et al. | Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI. | 2015 | J. Am. Soc. Mass Spectrom. | pmid:25822928 |
Slominski AT et al. | Novel activities of CYP11A1 and their potential physiological significance. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25448732 |
Muchalski H et al. | Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol. | 2015 | Org. Biomol. Chem. | pmid:25435103 |
Endo-Umeda K et al. | 7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity. | 2014 | J. Steroid Biochem. Mol. Biol. | pmid:24269243 |
Clausen DN et al. | Development of molecularly imprinted poly(methacrylic acid)/silica for clean-up and selective extraction of cholesterol in milk prior to analysis by HPLC-UV. | 2014 | Analyst | pmid:25068793 |
Gelzo M et al. | Evaluation of cytotoxic effects of 7-dehydrocholesterol on melanoma cells. | 2014 | Free Radic. Biol. Med. | pmid:24561580 |
Rosecrans R and Dohnal JC | Seasonal vitamin D changes and the impact on health risk assessment. | 2014 | Clin. Biochem. | pmid:24525255 |
Bzdúch V et al. | [Historical aspects of the Smith-Lemli-Opitz syndrome]. | 2014 | Cas. Lek. Cesk. | pmid:24506692 |
Goyal S et al. | Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. | 2014 | J. Lipid Res. | pmid:25017465 |
Merkens MJ et al. | Feeding impairments associated with plasma sterols in Smith-Lemli-Opitz syndrome. | 2014 | J. Pediatr. | pmid:25039049 |
Xu L and Porter NA | Reactivities and products of free radical oxidation of cholestadienols. | 2014 | J. Am. Chem. Soc. | pmid:24625033 |
Björkhem I et al. | On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO. | 2014 | J. Lipid Res. | pmid:24771866 |
Ganmaa D et al. | Vitamin D deficiency in reproductive age Mongolian women: a cross sectional study. | 2014 | J. Steroid Biochem. Mol. Biol. | pmid:24076033 |
Holick MF | Sunlight, ultraviolet radiation, vitamin D and skin cancer: how much sunlight do we need? | 2014 | Adv. Exp. Med. Biol. | pmid:25207357 |
Liu W et al. | A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. | 2014 | J. Lipid Res. | pmid:24259532 |
Hall P et al. | Aripiprazole and trazodone cause elevations of 7-dehydrocholesterol in the absence of Smith-Lemli-Opitz Syndrome. | 2013 Sep-Oct | Mol. Genet. Metab. | pmid:23628460 |
Kawamoto H et al. | An efficient synthesis of 4α- and 4β-hydroxy- 7-dehydrocholesterol, biomarkers for patients with and animal models of the Smith-Lemli-Opitz syndrome. | 2013 Oct-Nov | Chem. Phys. Lipids | pmid:23920082 |