| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Total
4
7-Dehydrocholesterol
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 7-Dehydrocholesterol?
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
PubChem Associated disorders and diseases
What pathways are associated with 7-Dehydrocholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 7-Dehydrocholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 7-Dehydrocholesterol?
Mouse Model
Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 7-Dehydrocholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xu Y et al. | Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. | 2009 | Respir. Res. | pmid:19344509 |
| Korade Z et al. | NRIF is a regulator of neuronal cholesterol biosynthesis genes. | 2009 | J. Mol. Neurosci. | pmid:18677445 |
| Jeibmann A and Paulus W | Drosophila melanogaster as a model organism of brain diseases. | 2009 | Int J Mol Sci | pmid:19333415 |
| Kolejáková K et al. | Spectrum of DHCR7 mutations in Slovak patients with Smith-Lemli-Opitz syndrome and detection of common mutations by PCR-based assays. | 2009 | Gen. Physiol. Biophys. | pmid:19390132 |
| Oberthür A et al. | [Smith-Lemli-Opitz syndrome--case report, diagnostics and therapeutic options]. | 2009 | Z Geburtshilfe Neonatol | pmid:19856245 |
| Fernandes de Abreu DA et al. | Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. | 2009 | Psychoneuroendocrinology | pmid:19545951 |
| Yavuz B et al. | Increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins? | 2009 | Cardiovasc Drugs Ther | pmid:19543962 |
| Ukinc K | Severe osteomalacia presenting with multiple vertebral fractures: a case report and review of the literature. | 2009 | Endocrine | pmid:19543841 |
| Mousavi M et al. | A (13)C solid-state NMR analysis of vitamin D compounds. | 2009 | Solid State Nucl Magn Reson | pmid:19493660 |
| Zechi-Ceide RM et al. | Holoprosencephaly, ectrodactyly, and bilateral cleft of lip and palate: exclusion of SHH, TGIF, SIX3, GLI2, TP73L, and DHCR7 as candidate genes. | 2009 | Am. J. Med. Genet. A | pmid:19449411 |
| Choi BK et al. | Proteomic analysis of the sterol-mediated signaling pathway in Caenorhabditis elegans. | 2009 | Methods Mol. Biol. | pmid:19160669 |
| Li X et al. | Epithelial Cell Gene Expression Induced by Intracellular Staphylococcus aureus. | 2009 | Int J Microbiol | pmid:20016671 |
| Lehmann B | Role of the vitamin D3 pathway in healthy and diseased skin--facts, contradictions and hypotheses. | 2009 | Exp. Dermatol. | pmid:19146580 |
| Janjetovic Z et al. | 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes. | 2009 | PLoS ONE | pmid:19543524 |
| Korade Z et al. | Molecular consequences of altered neuronal cholesterol biosynthesis. | 2009 | J. Neurosci. Res. | pmid:18951487 |
| Benvenuto A et al. | Recent advances in the pathogenesis of syndromic autisms. | 2009 | Int J Pediatr | pmid:19946417 |
| Sobrino A et al. | Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells. | 2009 | PLoS ONE | pmid:20011585 |
| Snellman G et al. | Seasonal genetic influence on serum 25-hydroxyvitamin D levels: a twin study. | 2009 | PLoS ONE | pmid:19915719 |
| Bossé Y et al. | Asthma and genes encoding components of the vitamin D pathway. | 2009 | Respir. Res. | pmid:19852851 |
| Jiang Z et al. | Discovery of novel genetic networks associated with 19 economically important traits in beef cattle. | 2009 | Int. J. Biol. Sci. | pmid:19727437 |
| Xu L et al. | Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes. | 2009 | J. Am. Chem. Soc. | pmid:19705847 |
| Seifert M et al. | Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro. | 2009 | Anticancer Res. | pmid:19667162 |
| Glass D et al. | Pigmentation and vitamin D metabolism in Caucasians: low vitamin D serum levels in fair skin types in the UK. | 2009 | PLoS ONE | pmid:19649299 |
| Epstein E et al. | A population-based cohort study on sun habits and endometrial cancer. | 2009 | Br. J. Cancer | pmid:19550419 |
| Hu VW et al. | Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis. | 2009 | PLoS ONE | pmid:19492049 |
| Cardinal RN and Gregory CA | Osteomalacia and vitamin D deficiency in a psychiatric rehabilitation unit: case report and survey. | 2009 | BMC Res Notes | pmid:19426538 |
| Honkala H et al. | Unraveling the disease pathogenesis behind lethal hydrolethalus syndrome revealed multiple changes in molecular and cellular level. | 2009 | Pathogenetics | pmid:19400947 |
| Wilson CW et al. | Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. | 2009 | PLoS ONE | pmid:19365551 |
| Moliner C et al. | Evidence that the intra-amoebal Legionella drancourtii acquired a sterol reductase gene from eukaryotes. | 2009 | BMC Res Notes | pmid:19327142 |
| Ramagopalan SV et al. | Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. | 2009 | PLoS Genet. | pmid:19197344 |
| Bozek K et al. | Regulation of clock-controlled genes in mammals. | 2009 | PLoS ONE | pmid:19287494 |
| Moy SS et al. | Social approach in genetically engineered mouse lines relevant to autism. | 2009 | Genes Brain Behav. | pmid:19016890 |
| Slominski AT et al. | Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. | 2009 | PLoS ONE | pmid:19190754 |
| Rodgers MA et al. | Identification of an overabundant cholesterol precursor in hepatitis B virus replicating cells by untargeted lipid metabolite profiling. | 2009 | J. Am. Chem. Soc. | pmid:19301856 |
| Warren JT et al. | Studies on the Black Box: incorporation of 3-oxo-7-dehydrocholesterol into ecdysteroids by Drosophila melanogaster and Manduca sexta. | 2009 | Insect Biochem. Mol. Biol. | pmid:19699302 |
| Rangel NL et al. | Light-activated molecular conductivity in the photoreactions of vitamin D3. | 2009 | J Phys Chem A | pmid:19514787 |
| Sordillo J et al. | Development of a new isotopically labeled internal standard for ergosterol measurement by GC/MS. | 2009 | J Environ Monit | pmid:19657536 |
| Le Martelot G et al. | REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. | 2009 | PLoS Biol. | pmid:19721697 |
| Olds WJ and Kimlin MG | Authors' Reply to: Comment on "In vitro model of vitamin D(3) (cholecalciferol) synthesis by UV radiation: Dose-response relationships" by W.J. Olds, A.R. McKinley, M.R. Moore and M.G. Kimlin, J. Photochem. Photobiol. B: Biol. 93 (2008) 88-93. | 2009 | J. Photochem. Photobiol. B, Biol. | pmid:19879156 |
| Acimovic J et al. | Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19525158 |
| Matabosch X et al. | Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase (Dhcr7), the enzyme associated with Smith-Lemli-Opitz syndrome. | 2009 | J. Steroid Biochem. Mol. Biol. | pmid:19406241 |
| Kuehnle K et al. | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. | 2009 | Neurochem. Res. | pmid:19115107 |
| Björn LO et al. | Comment on "In vitro model of vitamin D(3) (cholecalciferol) synthesis by UV radiation: dose-response relationships" by W.J. Olds, A.R. McKinley, M.R. Moore and M.G. Kimlin, J. Photochem. Photobiol. B: Biol. 93 (2008) 88-93. | 2009 | J. Photochem. Photobiol. B, Biol. | pmid:19269846 |
| Rakheja D and Boriack RL | Precholesterol sterols accumulate in lipid rafts of patients with Smith-Lemli-Opitz syndrome and X-linked dominant chondrodysplasia punctata. | 2008 Mar-Apr | Pediatr. Dev. Pathol. | pmid:17378665 |
| Jezela-Stanek A et al. | Mild Smith-Lemli-Opitz syndrome: further delineation of 5 Polish cases and review of the literature. | 2008 Mar-Apr | Eur J Med Genet | pmid:18249054 |
| Leaver MJ et al. | Functional genomics reveals increases in cholesterol biosynthetic genes and highly unsaturated fatty acid biosynthesis after dietary substitution of fish oil with vegetable oils in Atlantic salmon (Salmo salar). | 2008 | BMC Genomics | pmid:18577222 |
| Lonne-Rahm SB et al. | Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress. | 2008 | J Eur Acad Dermatol Venereol | pmid:18181968 |
| Rewitz KF and Gilbert LI | Daphnia Halloween genes that encode cytochrome P450s mediating the synthesis of the arthropod molting hormone: evolutionary implications. | 2008 | BMC Evol. Biol. | pmid:18298845 |
| Kervizic G and Corcos L | Dynamical modeling of the cholesterol regulatory pathway with Boolean networks. | 2008 | BMC Syst Biol | pmid:19025648 |
| Oh Y et al. | Transcriptome analysis reveals new insight into appressorium formation and function in the rice blast fungus Magnaporthe oryzae. | 2008 | Genome Biol. | pmid:18492280 |
| Liss J et al. | Pregnancy and life after preimplantation genetic diagnosis of Smith-Lemli-Opitz syndrome. | 2008 | Fertil. Steril. | pmid:18442819 |
| Payré B et al. | Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. | 2008 | Mol. Cancer Ther. | pmid:19074846 |
| Holick MF | Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? | 2008 | Adv. Exp. Med. Biol. | pmid:18348443 |
| Witsch-Baumgartner M et al. | Age and origin of major Smith-Lemli-Opitz syndrome (SLOS) mutations in European populations. | 2008 | J. Med. Genet. | pmid:17965227 |
| Chittur SV et al. | Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. | 2008 | BMC Genomics | pmid:18959802 |
| de Sain-van der Velden MG et al. | Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX. | 2008 | J. Inherit. Metab. Dis. | pmid:18949577 |
| Lyssenko NN et al. | An unexpectedly high degree of specialization and a widespread involvement in sterol metabolism among the C. elegans putative aminophospholipid translocases. | 2008 | BMC Dev. Biol. | pmid:18831765 |
| Paik MJ et al. | Gas chromatographic-mass spectrometric analyses of cholesterol and its precursors in rat plasma as tert-butyldimethylsilyl derivatives. | 2008 | Clin. Chim. Acta | pmid:18657530 |
| Sunyecz JA | The use of calcium and vitamin D in the management of osteoporosis. | 2008 | Ther Clin Risk Manag | pmid:19209265 |
| Cutolo M | Vitamin D or hormone D deficiency in autoimmune rheumatic diseases, including undifferentiated connective tissue disease. | 2008 | Arthritis Res. Ther. | pmid:19090978 |
| Radonovich LJ et al. | Influenza and ultraviolet germicidal irradiation. | 2008 | Virol. J. | pmid:19087288 |
| Bürglin TR | The Hedgehog protein family. | 2008 | Genome Biol. | pmid:19040769 |
| van Erk MJ et al. | Short-term fatty acid intervention elicits differential gene expression responses in adipose tissue from lean and overweight men. | 2008 | Genes Nutr | pmid:19034550 |
| Li Q et al. | Revisiting oocyte-somatic cell interactions: in search of novel intrafollicular predictors and regulators of oocyte developmental competence. | 2008 | Mol. Hum. Reprod. | pmid:18996952 |
| Vondracek SF et al. | Clinical challenges in the management of osteoporosis. | 2008 | Clin Interv Aging | pmid:18686753 |
| Becker B et al. | Chlamydial genes shed light on the evolution of photoautotrophic eukaryotes. | 2008 | BMC Evol. Biol. | pmid:18627593 |
| Boesze-Battaglia K et al. | Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome. | 2008 | J. Lipid Res. | pmid:18344409 |
| Chang ML et al. | Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis. | 2008 | BMC Genomics | pmid:18307821 |
| Porter FD | Smith-Lemli-Opitz syndrome: pathogenesis, diagnosis and management. | 2008 | Eur. J. Hum. Genet. | pmid:18285838 |
| Bolland MJ et al. | Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report. | 2008 | Ann. Clin. Microbiol. Antimicrob. | pmid:18226256 |
| Morvan J and Tooze SA | Discovery and progress in our understanding of the regulated secretory pathway in neuroendocrine cells. | 2008 | Histochem. Cell Biol. | pmid:18197413 |
| Yoshida T et al. | Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry. | 2008 | Anal Chem Insights | pmid:19609389 |
| Paila YD et al. | Signaling by the human serotonin(1A) receptor is impaired in cellular model of Smith-Lemli-Opitz Syndrome. | 2008 | Biochim. Biophys. Acta | pmid:18381059 |
| Javitt NB | Oxysterols: novel biologic roles for the 21st century. | 2008 | Steroids | pmid:18068744 |
| Róg T et al. | Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers. | 2008 | J Chem Phys | pmid:19045210 |
| Olds WJ et al. | In vitro model of vitamin D3 (cholecalciferol) synthesis by UV radiation: dose-response relationships. | 2008 | J. Photochem. Photobiol. B, Biol. | pmid:18755599 |
| Guizzetti M and Costa LG | Sonic hedgehog in Smith-Lemli-Opitz syndrome and tumor development. | 2008 | J. Pediatr. Hematol. Oncol. | pmid:18776754 |
| Oslejskova H et al. | Malignant intracranial germinoma in Smith-Lemli-Opitz syndrome: cholesterol homeostasis possibly connecting morphogenesis and cancer development. | 2008 | J. Pediatr. Hematol. Oncol. | pmid:18776762 |
| Shrivastava S et al. | Differential effects of cholesterol and its immediate biosynthetic precursors on membrane organization. | 2008 | Biochemistry | pmid:18442257 |
| Marcos J et al. | Cholesterol biosynthesis from birth to adulthood in a mouse model for 7-dehydrosterol reductase deficiency (Smith-Lemli-Opitz syndrome). | 2007 | Steroids | pmid:17714750 |
| Eapen BR | Photosensitivity in Smith-Lemli-Opitz syndrome: a flux balance analysis of altered metabolism. | 2007 | Bioinformation | pmid:18188427 |
| Singh P et al. | Differential effects of cholesterol and 7-dehydrocholesterol on the ligand binding activity of the hippocampal serotonin(1A) receptor: implications in SLOS. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17493586 |
| Samuli Ollila OH et al. | Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol. | 2007 | J. Struct. Biol. | pmid:17369050 |
| Javitt NB | Oxysterols: functional significance in fetal development and the maintenance of normal retinal function. | 2007 | Curr. Opin. Lipidol. | pmid:17495602 |
| Pérez-Castrillón JL et al. | Effects of Atorvastatin on vitamin D levels in patients with acute ischemic heart disease. | 2007 | Am. J. Cardiol. | pmid:17398180 |
| Haas D et al. | Effects of cholesterol and simvastatin treatment in patients with Smith-Lemli-Opitz syndrome (SLOS). | 2007 | J. Inherit. Metab. Dis. | pmid:17497248 |
| Waye JS et al. | De novo mutation of the DHCR7 gene in a fetus with severe Smith-Lemli-Opitz (or RSH) syndrome. | 2007 | Am. J. Med. Genet. A | pmid:17595012 |
| Waye JS et al. | Prenatal diagnosis of Smith-Lemli-Opitz syndrome (SLOS) by DHCR7 mutation analysis. | 2007 | Prenat. Diagn. | pmid:17441222 |
| Bzduch V et al. | Sacral dimple as a skin manifestation of the Smith-Lemli-Opitz syndrome. | 2007 | J. Inherit. Metab. Dis. | pmid:17347909 |
| Sayre RM et al. | Reintroduction of a classic vitamin D ultraviolet source. | 2007 | J. Steroid Biochem. Mol. Biol. | pmid:17293107 |
| Dixon KM et al. | In vivo relevance for photoprotection by the vitamin D rapid response pathway. | 2007 | J. Steroid Biochem. Mol. Biol. | pmid:17223553 |
| Chattopadhyay A et al. | Differential effects of cholesterol and 7-dehydrocholesterol on ligand binding of solubilized hippocampal serotonin1A receptors: implications in SLOS. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17904101 |
| Mabley JG et al. | Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D. | 2007 | Int. J. Mol. Med. | pmid:17487428 |
| Osmancevic A et al. | UVB therapy increases 25(OH) vitamin D syntheses in postmenopausal women with psoriasis. | 2007 | Photodermatol Photoimmunol Photomed | pmid:17803595 |
| van der Mei IA et al. | The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude. | 2007 | Environ. Health Perspect. | pmid:17687438 |
| Otani T et al. | Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. | 2007 | Br. J. Cancer | pmid:17622244 |
| Neuprez A et al. | Vitamin D inadequacy in Belgian postmenopausal osteoporotic women. | 2007 | BMC Public Health | pmid:17462085 |
| Hagiwara K et al. | Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice. | 2007 | Biol. Pharm. Bull. | pmid:17409533 |
| Wilcox CB et al. | Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. | 2007 | BMC Cancer | pmid:18070364 |
| Steffen KM et al. | Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. | 2007 | J Perinatol | pmid:17855807 |