| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Total
4
7-Dehydrocholesterol
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 7-Dehydrocholesterol?
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
PubChem Associated disorders and diseases
What pathways are associated with 7-Dehydrocholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 7-Dehydrocholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 7-Dehydrocholesterol?
Mouse Model
Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 7-Dehydrocholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arruda BC et al. | Photochemical ring-opening and ground state relaxation in α-terpinene with comparison to provitamin D3. | 2013 | J Phys Chem B | pmid:23387423 |
| Singh P et al. | Differential effect of sterols on dipole potential in hippocampal membranes: implications for receptor function. | 2013 | Biochim. Biophys. Acta | pmid:23201544 |
| Keller RK et al. | Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz Syndrome. | 2013 | Lipids | pmid:23361583 |
| Dixon KM et al. | Vitamin D and death by sunshine. | 2013 | Int J Mol Sci | pmid:23334476 |
| Korade Z et al. | Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome. | 2013 | J. Inherit. Metab. Dis. | pmid:22718275 |
| Porter NA | A perspective on free radical autoxidation: the physical organic chemistry of polyunsaturated fatty acid and sterol peroxidation. | 2013 | J. Org. Chem. | pmid:23445181 |
| Rajeev R and Sunoj RB | Mechanism and stereoselectivity of biologically important oxygenation reactions of the 7-dehydrocholesterol radical. | 2013 | J. Org. Chem. | pmid:23829766 |
| Kuan V et al. | DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudes. | 2013 | BMC Evol. Biol. | pmid:23837623 |
| Windsor K et al. | Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome. | 2013 | J. Lipid Res. | pmid:23828810 |
| Satué M et al. | UV photoactivation of 7-dehydrocholesterol on titanium implants enhances osteoblast differentiation and decreases Rankl gene expression. | 2013 | Acta Biomater | pmid:23201015 |
| Xu L et al. | Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells. | 2013 | J. Lipid Res. | pmid:23381570 |
| Shimomura H et al. | Detoxification of 7-dehydrocholesterol fatal to Helicobacter pylori is a novel role of cholesterol glucosylation. | 2013 | J. Bacteriol. | pmid:23144252 |
| Satué M et al. | UV-irradiated 7-dehydrocholesterol coating on polystyrene surfaces is converted to active vitamin D by osteoblastic MC3T3-E1 cells. | 2013 | Photochem. Photobiol. Sci. | pmid:23538933 |
| Pondeville E et al. | Microarray and RNAi analysis of P450s in Anopheles gambiae male and female steroidogenic tissues: CYP307A1 is required for ecdysteroid synthesis. | 2013 | PLoS ONE | pmid:24324583 |
| Kohler M et al. | Influence of altitude on vitamin D and bone metabolism of lactating sheep and goats. | 2013 | J. Anim. Sci. | pmid:24045489 |
| Desotelle JA et al. | The circadian control of skin and cutaneous photodamage. | 2012 Sep-Oct | Photochem. Photobiol. | pmid:22277067 |
| Radlović N et al. | Vitamin D in the light of current knowledge. | 2012 Jan-Feb | Srp Arh Celok Lek | pmid:22462359 |
| Liu JL et al. | Mitochondrial oxidative stress alters a pathway in Caenorhabditis elegans strongly resembling that of bile acid biosynthesis and secretion in vertebrates. | 2012 | PLoS Genet. | pmid:22438816 |
| Chen C and Tripp CP | A comparison of the behavior of cholesterol, 7-dehydrocholesterol and ergosterol in phospholipid membranes. | 2012 | Biochim. Biophys. Acta | pmid:22465065 |
| Xu L et al. | 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. | 2012 | Biochim. Biophys. Acta | pmid:22425966 |