| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Total
4
7-Dehydrocholesterol
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 7-Dehydrocholesterol?
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
PubChem Associated disorders and diseases
What pathways are associated with 7-Dehydrocholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 7-Dehydrocholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 7-Dehydrocholesterol?
Mouse Model
Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with 7-Dehydrocholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Davies JR et al. | The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate. | 2011 | Cancer Causes Control | pmid:21853245 |
| Yoshiyama-Yanagawa T et al. | The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme. | 2011 | J. Biol. Chem. | pmid:21632547 |
| Mason RS | Vitamin D: a hormone for all seasons. | 2011 | Climacteric | pmid:20964549 |
| Mykles DL | Ecdysteroid metabolism in crustaceans. | 2011 | J. Steroid Biochem. Mol. Biol. | pmid:20837145 |
| Holick MF | Vitamin D: evolutionary, physiological and health perspectives. | 2011 | Curr Drug Targets | pmid:20795941 |
| Nes WD | Biosynthesis of cholesterol and other sterols. | 2011 | Chem. Rev. | pmid:21902244 |
| Yamamoto M et al. | Structural requirements of virion-associated cholesterol for infectivity, buoyant density and apolipoprotein association of hepatitis C virus. | 2011 | J. Gen. Virol. | pmid:21593275 |
| Schmidt S et al. | Coping with time scales in disease systems analysis: application to bone remodeling. | 2011 | J Pharmacokinet Pharmacodyn | pmid:22028207 |
| Ko HS et al. | Prenatal diagnosis of congenital lipoid adrenal hyperplasia (CLAH) by molecular genetic testing in Korean siblings. | 2011 | Yonsei Med. J. | pmid:22028173 |
| Kim HS et al. | Vitamin d, and kidney disease. | 2011 | Electrolyte Blood Press | pmid:21998600 |
| Donkena KV and Young CY | Vitamin d, sunlight and prostate cancer risk. | 2011 | Adv Prev Med | pmid:21991434 |
| Ziats MN and Rennert OM | Expression profiling of autism candidate genes during human brain development implicates central immune signaling pathways. | 2011 | PLoS ONE | pmid:21935439 |
| Mallah EM et al. | Plasma concentrations of 25-hydroxyvitamin D among Jordanians: Effect of biological and habitual factors on vitamin D status. | 2011 | BMC Clin Pathol | pmid:21816088 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Shaman J et al. | Shortcomings of vitamin D-based model simulations of seasonal influenza. | 2011 | PLoS ONE | pmid:21677774 |
| Sloka S et al. | Predominance of Th2 polarization by vitamin D through a STAT6-dependent mechanism. | 2011 | J Neuroinflammation | pmid:21605467 |
| Chakraborti CK | Vitamin D as a promising anticancer agent. | 2011 | Indian J Pharmacol | pmid:21572642 |
| Niwa R and Niwa YS | The Fruit Fly Drosophila melanogaster as a Model System to Study Cholesterol Metabolism and Homeostasis. | 2011 | Cholesterol | pmid:21512589 |
| Kim CJ | Vitamin D dependent rickets type I. | 2011 | Korean J Pediatr | pmid:21503197 |
| Singh P et al. | Transcriptomic analysis in a Drosophila model identifies previously implicated and novel pathways in the therapeutic mechanism in neuropsychiatric disorders. | 2011 | Front Neurosci | pmid:21503142 |
| Castro R et al. | The effect of light on critical illness. | 2011 | Crit Care | pmid:21457502 |
| Cooper JD et al. | Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. | 2011 | Diabetes | pmid:21441443 |
| Larkin EK et al. | Agreement of blood spot card measurements of vitamin D levels with serum, whole blood specimen types and a dietary recall instrument. | 2011 | PLoS ONE | pmid:21304997 |
| Mkhikian H et al. | Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. | 2011 | Nat Commun | pmid:21629267 |
| Bours PH et al. | Seasonal variation of serum 25-hydroxyvitamin D levels in adult patients with inflammatory bowel disease. | 2011 | Osteoporos Int | pmid:21113577 |
| Stottmann RW et al. | Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. | 2011 | PLoS Genet. | pmid:21912524 |
| Wicherts IS et al. | Sunlight exposure or vitamin D supplementation for vitamin D-deficient non-western immigrants: a randomized clinical trial. | 2011 | Osteoporos Int | pmid:20683712 |
| Tang JY et al. | Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas. | 2011 | Cancer Prev Res (Phila) | pmid:21436386 |
| Vanmierlo T et al. | Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. | 2011 | Plant Foods Hum Nutr | pmid:21431910 |
| Ou Q et al. | Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development. | 2011 | PLoS Biol. | pmid:21980261 |
| Fedorov VB et al. | Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus). | 2011 | BMC Genomics | pmid:21453527 |
| Orsi M and Essex JW | The ELBA force field for coarse-grain modeling of lipid membranes. | 2011 | PLoS ONE | pmid:22194874 |
| Bianconi SE et al. | Adrenal function in Smith-Lemli-Opitz syndrome. | 2011 | Am. J. Med. Genet. A | pmid:21990131 |
| Sauer SW et al. | Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease. | 2011 | Biochim. Biophys. Acta | pmid:21920437 |
| Athippozhy A et al. | Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. | 2011 | BMC Genomics | pmid:21291544 |
| Cheng D et al. | Lipid pathway alterations in Parkinson's disease primary visual cortex. | 2011 | PLoS ONE | pmid:21387008 |
| Shah I et al. | Misleading measures in Vitamin D analysis: a novel LC-MS/MS assay to account for epimers and isobars. | 2011 | Nutr J | pmid:21569549 |
| Mason RS et al. | Vitamin D: the light side of sunshine. | 2011 | Eur J Clin Nutr | pmid:21731037 |
| Bidet M et al. | The hedgehog receptor patched is involved in cholesterol transport. | 2011 | PLoS ONE | pmid:21931618 |
| Selmi C et al. | Environmental pathways to autoimmune diseases: the cases of primary biliary cirrhosis and multiple sclerosis. | 2011 | Arch Med Sci | pmid:22295019 |
| Boone LR et al. | Mechanism of resistance to dietary cholesterol. | 2011 | J Lipids | pmid:22007308 |
| Acimovic J et al. | Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis. | 2011 | Drug Metab. Dispos. | pmid:20952551 |
| Ren G et al. | Alterations in membrane caveolae and BKCa channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome. | 2011 | Mol. Genet. Metab. | pmid:21724437 |
| Tang KC and Sension RJ | The influence of the optical pulse shape on excited state dynamics in provitamin D3. | 2011 | Faraday Discuss. | pmid:22452077 |
| Larsen L et al. | Expression and localization of microRNAs in perinatal rat pancreas: role of miR-21 in regulation of cholesterol metabolism. | 2011 | PLoS ONE | pmid:22022489 |
| Kaddurah-Daouk R et al. | Enteric microbiome metabolites correlate with response to simvastatin treatment. | 2011 | PLoS ONE | pmid:22022402 |
| Blanc M et al. | Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. | 2011 | PLoS Biol. | pmid:21408089 |
| Xu L et al. | Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. | 2011 | J. Lipid Res. | pmid:21817059 |
| Dalgård C et al. | Vitamin D status in relation to glucose metabolism and type 2 diabetes in septuagenarians. | 2011 | Diabetes Care | pmid:21515843 |
| AÄimoviÄ J et al. | Circadian rhythm of cholesterol synthesis in mouse liver: a statistical analysis of the post-squalene metabolites in wild-type and Crem-knock-out mice. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21531203 |