| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Abnormalities, Multiple | D000015 | 13 associated lipids |
| Intellectual Disability | D008607 | 13 associated lipids |
| Smith-Lemli-Opitz Syndrome | D019082 | 7 associated lipids |
Total
4
7-Dehydrocholesterol
7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.
Cross Reference
Introduction
To understand associated biological information of 7-Dehydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 7-Dehydrocholesterol?
7-Dehydrocholesterol is suspected in Dehydration, Congenital Abnormality, Exanthema, Vitamin D Deficiency, Retinal Degeneration, Hereditary Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 7-Dehydrocholesterol
PubChem Associated disorders and diseases
What pathways are associated with 7-Dehydrocholesterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 7-Dehydrocholesterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 7-Dehydrocholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 7-Dehydrocholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 7-Dehydrocholesterol?
Mouse Model
Mouse Model are used in the study 'An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome.' (Xu L et al., 2011) and Mouse Model are used in the study 'Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.' (Xu L et al., 2013).
Knock-out
Knock-out are used in the study 'Immunoglobulin E receptor signaling and asthma.' (Wu LC, 2011) and Knock-out are used in the study 'Novel activities of CYP11A1 and their potential physiological significance.' (Slominski AT et al., 2015).
Rodent Model
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014) and Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 7-Dehydrocholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yoshiyama-Yanagawa T et al. | The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme. | 2011 | J. Biol. Chem. | pmid:21632547 |
| Zarowski M et al. | Prevalence of sleep problems in Smith-Lemli-Opitz syndrome. | 2011 | Am. J. Med. Genet. A | pmid:21626671 |
| Nowaczyk MJ | Epiphyseal stippling is not a feature of 7-dehydrocholesterol reductase deficiency (Smith-Lemli-Opitz syndrome). | 2011 | Am. J. Med. Genet. A | pmid:21595006 |
| Mason RS | Vitamin D: a hormone for all seasons. | 2011 | Climacteric | pmid:20964549 |
| Yamamoto M et al. | Structural requirements of virion-associated cholesterol for infectivity, buoyant density and apolipoprotein association of hepatitis C virus. | 2011 | J. Gen. Virol. | pmid:21593275 |
| Gimenez G et al. | Insight into cross-talk between intra-amoebal pathogens. | 2011 | BMC Genomics | pmid:22047552 |
| Kupfer SS et al. | Genetic associations in the vitamin D receptor and colorectal cancer in African Americans and Caucasians. | 2011 | PLoS ONE | pmid:22046258 |
| Schmidt S et al. | Coping with time scales in disease systems analysis: application to bone remodeling. | 2011 | J Pharmacokinet Pharmacodyn | pmid:22028207 |
| Ko HS et al. | Prenatal diagnosis of congenital lipoid adrenal hyperplasia (CLAH) by molecular genetic testing in Korean siblings. | 2011 | Yonsei Med. J. | pmid:22028173 |
| Vejux A et al. | Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments. | 2011 | J Ophthalmol | pmid:21577274 |
| Shaman J et al. | Shortcomings of vitamin D-based model simulations of seasonal influenza. | 2011 | PLoS ONE | pmid:21677774 |
| Sloka S et al. | Predominance of Th2 polarization by vitamin D through a STAT6-dependent mechanism. | 2011 | J Neuroinflammation | pmid:21605467 |
| Chakraborti CK | Vitamin D as a promising anticancer agent. | 2011 | Indian J Pharmacol | pmid:21572642 |
| Mkhikian H et al. | Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. | 2011 | Nat Commun | pmid:21629267 |
| Bours PH et al. | Seasonal variation of serum 25-hydroxyvitamin D levels in adult patients with inflammatory bowel disease. | 2011 | Osteoporos Int | pmid:21113577 |
| Elias PM et al. | Pathogenesis of the cutaneous phenotype in inherited disorders of cholesterol metabolism: Therapeutic implications for topical treatment of these disorders. | 2011 | Dermatoendocrinol | pmid:21695019 |
| Boone LR et al. | Mechanism of resistance to dietary cholesterol. | 2011 | J Lipids | pmid:22007308 |
| Acimovic J et al. | Inhibition of human sterol Δ7-reductase and other postlanosterol enzymes by LK-980, a novel inhibitor of cholesterol synthesis. | 2011 | Drug Metab. Dispos. | pmid:20952551 |
| Larsen L et al. | Expression and localization of microRNAs in perinatal rat pancreas: role of miR-21 in regulation of cholesterol metabolism. | 2011 | PLoS ONE | pmid:22022489 |
| Kaddurah-Daouk R et al. | Enteric microbiome metabolites correlate with response to simvastatin treatment. | 2011 | PLoS ONE | pmid:22022402 |
| Idelevich A et al. | 1,25(OH)2D3 alters growth plate maturation and bone architecture in young rats with normal renal function. | 2011 | PLoS ONE | pmid:21695192 |
| AÄimoviÄ J et al. | Circadian rhythm of cholesterol synthesis in mouse liver: a statistical analysis of the post-squalene metabolites in wild-type and Crem-knock-out mice. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21531203 |
| Schmidt DA et al. | Quantifying the vitamin D3 synthesizing potential of UVB lamps at specific distances over time. | 2010 Nov-Dec | Zoo Biol. | pmid:20839282 |
| Lehmann B and Meurer M | Vitamin D metabolism. | 2010 Jan-Feb | Dermatol Ther | pmid:20136904 |
| Osmancevic A et al. | Vitamin D status in psoriasis patients during different treatments with phototherapy. | 2010 | J. Photochem. Photobiol. B, Biol. | pmid:20579901 |
| Auslander M et al. | The effect of tert-butyl hydroperoxide on hepatic transcriptome expression patterns in the striped sea bream (Lithognathus mormyrus; Teleostei). | 2010 | Free Radic. Res. | pmid:20553222 |
| Amaral C et al. | Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20630811 |
| Shaygannejad V et al. | A Comparative Study of 25 (OH) Vitamin D Serum Levels in Patients with Multiple Sclerosis and Control Group in Isfahan, Iran. | 2010 | Int J Prev Med | pmid:21566791 |
| Heppner HJ et al. | Laboratory aspects relating to the detection and prevention of frailty. | 2010 | Int J Prev Med | pmid:21566784 |
| Patti GJ et al. | Nanostructure-initiator mass spectrometry (NIMS) imaging of brain cholesterol metabolites in Smith-Lemli-Opitz syndrome. | 2010 | Neuroscience | pmid:20670678 |
| Alcolea PJ et al. | Temperature increase prevails over acidification in gene expression modulation of amastigote differentiation in Leishmania infantum. | 2010 | BMC Genomics | pmid:20074347 |
| Annweiler C et al. | Fall prevention and vitamin D in the elderly: an overview of the key role of the non-bone effects. | 2010 | J Neuroeng Rehabil | pmid:20937091 |
| Ma Y et al. | Vitamin D in combination cancer treatment. | 2010 | J Cancer | pmid:20842231 |
| Belin S et al. | Ascorbic Acid and gene expression: another example of regulation of gene expression by small molecules? | 2010 | Curr. Genomics | pmid:20808524 |
| Jiang XS et al. | Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications. | 2010 | Hum. Mol. Genet. | pmid:20067919 |
| Weaver DD et al. | Cyclopia (synophthalmia) in Smith-Lemli-Opitz syndrome: First reported case and consideration of mechanism. | 2010 | Am J Med Genet C Semin Med Genet | pmid:20104611 |
| Gohin M et al. | Comparative transcriptomic analysis of follicle-enclosed oocyte maturational and developmental competence acquisition in two non-mammalian vertebrates. | 2010 | BMC Genomics | pmid:20059772 |
| Nordin BE | Evolution of the calcium paradigm: the relation between vitamin D, serum calcium and calcium absorption. | 2010 | Nutrients | pmid:22254068 |
| Ko JS et al. | A novel DHCR7 mutation in a Smith-Lemli-Opitz syndrome infant presenting with neonatal cholestasis. | 2010 | J. Korean Med. Sci. | pmid:20052364 |
| Ullah MI et al. | Does vitamin d deficiency cause hypertension? Current evidence from clinical studies and potential mechanisms. | 2010 | Int J Endocrinol | pmid:20049157 |
| Maverakis E et al. | Light, including ultraviolet. | 2010 | J. Autoimmun. | pmid:20018479 |
| Rejnmark L et al. | Simvastatin does not affect vitamin d status, but low vitamin d levels are associated with dyslipidemia: results from a randomised, controlled trial. | 2010 | Int J Endocrinol | pmid:20016680 |
| Matabosch X et al. | Increasing cholesterol synthesis in 7-dehydrosterol reductase (DHCR7) deficient mouse models through gene transfer. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20800683 |
| Korade Z et al. | Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome. | 2010 | J. Lipid Res. | pmid:20702862 |
| Fuse S et al. | Continuous-flow synthesis of vitamin D3. | 2010 | Chem. Commun. (Camb.) | pmid:20877825 |
| Serra M et al. | Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20804844 |
| Chau PL | New insights into the molecular mechanisms of general anaesthetics. | 2010 | Br. J. Pharmacol. | pmid:20735416 |
| Fon Tacer K et al. | Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. | 2010 | J. Steroid Biochem. Mol. Biol. | pmid:20206258 |
| Pérez-Castrillón JL et al. | Vitamin d levels and lipid response to atorvastatin. | 2010 | Int J Endocrinol | pmid:20016682 |
| Sánchez-Wandelmer J et al. | Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells. | 2010 | Neuroscience | pmid:20123000 |