Ogilvie KM et al. |
The inhibitory effect of intracerebroventricularly injected interleukin 1beta on testosterone secretion in the rat: role of steroidogenic acute regulatory protein. |
1999 |
Biol. Reprod. |
pmid:9916024
|
Bosc MJ and Nicolle A |
Androstenedione and progesterone production in vitro by the inner or the outer theca cells in preovulatory follicles of gonadotropin stimulated calves. |
1998 |
Anim. Reprod. Sci. |
pmid:9672665
|
Dirami G and Cooke BA |
Effect of a dopamine agonist on luteinizing hormone receptors, cyclic AMP production and steroidogenesis in rat Leydig cells. |
1998 |
Toxicol. Appl. Pharmacol. |
pmid:9653071
|
Lin T et al. |
Interleukin-1 inhibits Leydig cell steroidogenesis without affecting steroidogenic acute regulatory protein messenger ribonucleic acid or protein levels. |
1998 |
J. Endocrinol. |
pmid:9582502
|
Lin T et al. |
Interferon-gamma inhibits the steroidogenic acute regulatory protein messenger ribonucleic acid expression and protein levels in primary cultures of rat Leydig cells. |
1998 |
Endocrinology |
pmid:9564825
|
Huang CJ et al. |
Synergistic activation of RLD-1 by agents triggering PKA and PKC dependent signalling. |
1998 |
Biochem. Biophys. Res. Commun. |
pmid:9500983
|
Marinero MJ et al. |
Specific effect of arachidonic acid on 17beta-hydroxysteroid dehydrogenase in rat Leydig cells. |
1998 |
FEBS Lett. |
pmid:9475159
|
Hawi SR et al. |
Raman microspectroscopy of intracellular cholesterol crystals in cultured bovine coronary artery endothelial cells. |
1997 |
J. Lipid Res. |
pmid:9300781
|
Lala DS et al. |
Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. |
1997 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:9144161
|
Lehmann JM et al. |
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. |
1997 |
J. Biol. Chem. |
pmid:9013544
|
Sugano S et al. |
Identification of intermediates in the conversion of cholesterol to pregnenolone with a reconstituted cytochrome p-450scc system: accumulation of the intermediate modulated by the adrenodoxin level. |
1996 |
J. Biochem. |
pmid:8947841
|
Pezzi V et al. |
Role of calmodulin-dependent protein kinase II in the acute stimulation of aldosterone production. |
1996 |
J. Steroid Biochem. Mol. Biol. |
pmid:8903426
|
Janowski BA et al. |
An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. |
1996 |
Nature |
pmid:8878485
|
Verhagen JC et al. |
Physical effects of biologically formed cholesterol oxidation products on lipid membranes investigated with fluorescence depolarization spectroscopy and electron spin resonance. |
1996 |
J. Lipid Res. |
pmid:8827521
|
Mele PG et al. |
Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland. |
1996 |
Biochim. Biophys. Acta |
pmid:8599603
|
Doris PA et al. |
Ouabain production by cultured adrenal cells. |
1996 |
Endocrinology |
pmid:8593799
|
Fitz TA et al. |
Effects of substrate supplementation with hydroxycholesterol analogues and serum lipoproteins on ovine luteal cell progesterone secretion in vitro: demonstration of prostaglandin F2 alpha luteolytic actions in a defined model system. |
1993 |
J. Reprod. Fertil. |
pmid:8464026
|
Freeman DA et al. |
Finasteride blocks progesterone synthesis in MA-10 Leydig tumor cells. |
1993 |
Endocrinology |
pmid:8404636
|
Boujrad N et al. |
Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam-binding inhibitor. |
1993 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:8390677
|
Sourdaine P and Garnier DH |
Stage-dependent modulation of Sertoli cell steroid production in dogfish (Scyliorhinus canicula). |
1993 |
J. Reprod. Fertil. |
pmid:8385221
|
Stocco DM et al. |
The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells. |
1993 |
Endocrinology |
pmid:8243310
|
Abayasekara DR et al. |
Mode of action of prostaglandin F2 alpha in human luteinized granulosa cells: role of protein kinase C. |
1993 |
Mol. Cell. Endocrinol. |
pmid:8143907
|
Khanna A et al. |
Heat shock protein induction blocks hormone-sensitive steroidogenesis in rat luteal cells. |
1994 |
Steroids |
pmid:8140601
|
Abayasekara RE and Flint AP |
A novel phospholipase C inhibitor U73122, inhibits phospholipase C-independent processes in rat luteal cells. |
1993 |
Biochem. Soc. Trans. |
pmid:8131934
|
Picard-Hagen N et al. |
Glucocorticoids enhance the cholesterol side-chain cleavage activity of ovine adrenocortical mitochondria. |
1995 |
J. Steroid Biochem. Mol. Biol. |
pmid:7577721
|
Brannian JD et al. |
Hydrogen peroxide suppresses low-density lipoprotein (LDL) uptake and LDL-supported steroidogenesis by porcine luteal cells. |
1995 |
Mol. Cell. Endocrinol. |
pmid:7556884
|
Musicki B et al. |
Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells. |
1994 |
Endocrinology |
pmid:7507829
|
Bates SR et al. |
Prevention of the hyperlipidemic serum or LDL-induced cellular cholesterol ester accumulation by 22-hydroxycholesterol and its analogue. |
1983 |
Biochim. Biophys. Acta |
pmid:6615863
|
Huijmans JG et al. |
Effects of some hydroxylated sterols on the steroid production in isolated rat adrenal glomerulosa and fasciculata/reticularis cells in the presence of potassium, angiotensin II or ACTH. |
1984 |
Acta Endocrinol. |
pmid:6322498
|
Huijmans JG et al. |
Conversion of 22S-hydroxy-cholesterol and its effects on the metabolism of other sterols in rat adrenal cells and bovine adrenal mitochondria. |
1982 |
Acta Endocrinol. |
pmid:6289587
|
Huijmans JG et al. |
Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. |
1981 |
Acta Endocrinol. |
pmid:6263029
|
Sullivan MH and Cooke BA |
Stimulation of cholesterol side-chain cleavage by a luteinizing-hormone-releasing hormone (luliberin) agonist (ICI 118630) in rat Leydig cells. |
1983 |
Biochem. J. |
pmid:6230077
|
Risbridger GP et al. |
The interaction of hCG, hydroxysteroids and interstitial fluid on rat Leydig cell steroidogenesis in vitro. |
1986 |
J. Reprod. Fertil. |
pmid:3723471
|
Cupp JR and Vickery LE |
Adrenodoxin with a COOH-terminal deletion (des 116-128) exhibits enhanced activity. |
1989 |
J. Biol. Chem. |
pmid:2912975
|
Yi M et al. |
Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. |
2017 |
Toxicol. Appl. Pharmacol. |
pmid:28729181
|
Carr BR and Mason JI |
The effects of alpha-human atrial natriuretic polypeptide on steroidogenesis by fetal zone cells of the human fetal adrenal gland. |
1988 |
Am. J. Obstet. Gynecol. |
pmid:2849878
|
Li J et al. |
Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis. |
2017 |
Reprod. Biol. Endocrinol. |
pmid:28302174
|
Yoshida K et al. |
Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. |
2018 |
Andrologia |
pmid:28295471
|
Venugopal S et al. |
Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. |
2016 |
J. Biol. Chem. |
pmid:27815506
|
Kim H et al. |
22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. |
2016 |
Biochim. Biophys. Acta |
pmid:27206966
|
Ceroi A et al. |
The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation. |
2016 |
Haematologica |
pmid:26635040
|
Davydov R et al. |
Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. |
2015 |
Biochemistry |
pmid:26603348
|
Huwait EA et al. |
Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages. |
2015 |
J. Cell. Biochem. |
pmid:25752819
|
Newby EA et al. |
Adrenocorticotropic Hormone and PI3K/Akt Inhibition Reduce eNOS Phosphorylation and Increase Cortisol Biosynthesis in Long-Term Hypoxic Ovine Fetal Adrenal Cortical Cells. |
2015 |
Reprod Sci |
pmid:25656500
|
Meikle AW et al. |
Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. |
1989 |
Am. J. Physiol. |
pmid:2558577
|
Na TY et al. |
22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. |
2015 |
J. Pathol. |
pmid:25557254
|
Soodgupta D et al. |
Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes. |
2014 |
Mol. Cell. Biochem. |
pmid:25283515
|
Wang JM et al. |
22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24704452
|
Trompier D et al. |
Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24480443
|
Slominski AT et al. |
In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. |
2014 |
Mol. Cell. Endocrinol. |
pmid:24382416
|
Gondcaille C et al. |
LXR antagonists induce ABCD2 expression. |
2014 |
Biochim. Biophys. Acta |
pmid:24239766
|
Mao D et al. |
ATF3 expression in the corpus luteum: possible role in luteal regression. |
2013 |
Mol. Endocrinol. |
pmid:24196350
|
Raccosta L et al. |
The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. |
2013 |
J. Exp. Med. |
pmid:23897983
|
Høgmoen Åstrand OA et al. |
(2S,3S)-2,6-dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. |
2013 |
Acta Crystallogr C |
pmid:23744388
|
Schaffer S et al. |
Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. |
2013 |
Biochem. Pharmacol. |
pmid:23665353
|
Olala LO et al. |
A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. |
2013 |
Mol. Cell. Endocrinol. |
pmid:23178798
|
Kumar R et al. |
Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. |
2012 |
Exp. Dermatol. |
pmid:23163651
|
Valbuena-Diez AC et al. |
Oxysterol-induced soluble endoglin release and its involvement in hypertension. |
2012 |
Circulation |
pmid:23110859
|
Soodvilai S et al. |
Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. |
2012 |
Am. J. Physiol. Renal Physiol. |
pmid:23077096
|
GarcÃa MM et al. |
Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. |
2012 |
Chem. Biol. Interact. |
pmid:22940207
|
El Roz A et al. |
LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. |
2012 |
Anticancer Res. |
pmid:22753765
|
Tranheim Kase E et al. |
Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. |
2012 |
Lipids |
pmid:22426832
|
Kittayaruksakul S et al. |
Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. |
2012 |
Am. J. Physiol. Renal Physiol. |
pmid:22169006
|
Lecanu L et al. |
A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. |
2012 |
Steroids |
pmid:22138207
|
Hessvik NP et al. |
The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. |
2012 |
J. Steroid Biochem. Mol. Biol. |
pmid:22051079
|
Ortega I et al. |
Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. |
2012 |
Biol. Reprod. |
pmid:21918126
|
Mastrocola R et al. |
Dysregulation of SREBP2 induces BACE1 expression. |
2011 |
Neurobiol. Dis. |
pmid:21726644
|
Guo H et al. |
Interleukin-2 is a potent inhibitor of Leydig cell steroidogenesis. |
1990 |
Endocrinology |
pmid:2167211
|
Cruz-Garcia L et al. |
Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. |
2011 |
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |
pmid:21635958
|
Papadopoulos V and Lecanu L |
Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. |
2012 |
J. Neuroendocrinol. |
pmid:21623958
|
Hedger MP and Eddy EM |
Leydig cell cooperation in vitro: evidence for communication between adult rat Leydig cells. |
1990 Jan-Feb |
J. Androl. |
pmid:2155894
|
Escobar JC et al. |
The human placenta expresses CYP17 and generates androgens de novo. |
2011 |
J. Clin. Endocrinol. Metab. |
pmid:21307141
|
Aye IL et al. |
Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. |
2011 |
Placenta |
pmid:21208656
|
Mast N et al. |
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. |
2011 |
J. Biol. Chem. |
pmid:21159775
|
Chuu CP and Lin HP |
Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. |
2010 |
Anticancer Res. |
pmid:20944148
|
Meikle AW et al. |
Extracellular calcium and luteinizing hormone effects on 22-hydroxycholesterol used for testosterone production in mouse Leydig cells. |
1991 Mar-Apr |
J. Androl. |
pmid:2050582
|
Chen W et al. |
Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. |
2010 |
Exp. Dermatol. |
pmid:20337700
|
Matsushita K et al. |
Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. |
2010 |
J. Biol. Chem. |
pmid:20118482
|
Adachi T et al. |
Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. |
2009 Nov-Dec |
Mol. Pharm. |
pmid:19588995
|
Morello F et al. |
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. |
2009 |
Atherosclerosis |
pmid:19426978
|
Minagawa H et al. |
Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. |
2009 |
J. Neurosci. Res. |
pmid:19326444
|
Demerjian M et al. |
Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. |
2009 |
Exp. Dermatol. |
pmid:19236478
|
Hynynen R et al. |
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. |
2009 |
J. Lipid Res. |
pmid:19224871
|
Arikan S and Yigit AA |
Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. |
2009 |
Anim. Reprod. Sci. |
pmid:19135321
|
Honda A et al. |
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. |
2009 |
J. Lipid Res. |
pmid:18815436
|
Lee JH et al. |
Androgen deprivation by activating the liver X receptor. |
2008 |
Endocrinology |
pmid:18450964
|
Ouimet M et al. |
Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. |
2008 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:18369155
|
Dodo K et al. |
Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
2008 |
Bioorg. Med. Chem. |
pmid:18343126
|
Qu JH et al. |
Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. |
2008 |
Toxicol. Lett. |
pmid:18053657
|
Bates SR et al. |
Expression and biological activity of ABCA1 in alveolar epithelial cells. |
2008 |
Am. J. Respir. Cell Mol. Biol. |
pmid:17884990
|
Yao ZX et al. |
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. |
2007 |
Neuroscience |
pmid:17689017
|
Wang YB et al. |
Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). |
2007 |
J. Toxicol. Environ. Health Part A |
pmid:17479410
|
Kase ET et al. |
22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. |
2006 |
Biochim. Biophys. Acta |
pmid:17055780
|
Piraino G et al. |
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
Shock |
pmid:16878022
|
Supornsilchai V et al. |
Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. |
2006 |
Reprod. Toxicol. |
pmid:16777379
|
Allen JA et al. |
Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. |
2006 |
Endocrinology |
pmid:16690799
|
Mauduit C et al. |
Tumor necrosis factor alpha inhibits gonadotropin action in cultured porcine Leydig cells: site(s) of action. |
1991 |
Endocrinology |
pmid:1659519
|
Cheng S et al. |
Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. |
2006 |
Toxicology |
pmid:16413094
|
Deng R et al. |
Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. |
2006 |
J. Pharmacol. Exp. Ther. |
pmid:16371446
|
Matsuzaki J et al. |
Immunosteroid as a regulator for Th1/Th2 balance: its possible role in autoimmune diseases. |
2005 |
Autoimmunity |
pmid:16227152
|