Yoshida K et al. |
Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. |
2018 |
Andrologia |
pmid:28295471
|
Yi M et al. |
Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. |
2017 |
Toxicol. Appl. Pharmacol. |
pmid:28729181
|
Li J et al. |
Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis. |
2017 |
Reprod. Biol. Endocrinol. |
pmid:28302174
|
Venugopal S et al. |
Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. |
2016 |
J. Biol. Chem. |
pmid:27815506
|
Kim H et al. |
22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. |
2016 |
Biochim. Biophys. Acta |
pmid:27206966
|
Ceroi A et al. |
The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation. |
2016 |
Haematologica |
pmid:26635040
|
Huwait EA et al. |
Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages. |
2015 |
J. Cell. Biochem. |
pmid:25752819
|
Newby EA et al. |
Adrenocorticotropic Hormone and PI3K/Akt Inhibition Reduce eNOS Phosphorylation and Increase Cortisol Biosynthesis in Long-Term Hypoxic Ovine Fetal Adrenal Cortical Cells. |
2015 |
Reprod Sci |
pmid:25656500
|
Na TY et al. |
22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. |
2015 |
J. Pathol. |
pmid:25557254
|
Davydov R et al. |
Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. |
2015 |
Biochemistry |
pmid:26603348
|
Trompier D et al. |
Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24480443
|
Wang JM et al. |
22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24704452
|
Gondcaille C et al. |
LXR antagonists induce ABCD2 expression. |
2014 |
Biochim. Biophys. Acta |
pmid:24239766
|
Slominski AT et al. |
In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. |
2014 |
Mol. Cell. Endocrinol. |
pmid:24382416
|
Soodgupta D et al. |
Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes. |
2014 |
Mol. Cell. Biochem. |
pmid:25283515
|
Mao D et al. |
ATF3 expression in the corpus luteum: possible role in luteal regression. |
2013 |
Mol. Endocrinol. |
pmid:24196350
|
Høgmoen Åstrand OA et al. |
(2S,3S)-2,6-dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. |
2013 |
Acta Crystallogr C |
pmid:23744388
|
Raccosta L et al. |
The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. |
2013 |
J. Exp. Med. |
pmid:23897983
|
Schaffer S et al. |
Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. |
2013 |
Biochem. Pharmacol. |
pmid:23665353
|
Olala LO et al. |
A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. |
2013 |
Mol. Cell. Endocrinol. |
pmid:23178798
|
El Roz A et al. |
LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. |
2012 |
Anticancer Res. |
pmid:22753765
|
Papadopoulos V and Lecanu L |
Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. |
2012 |
J. Neuroendocrinol. |
pmid:21623958
|
Hessvik NP et al. |
The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. |
2012 |
J. Steroid Biochem. Mol. Biol. |
pmid:22051079
|
Lecanu L et al. |
A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. |
2012 |
Steroids |
pmid:22138207
|
GarcÃa MM et al. |
Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. |
2012 |
Chem. Biol. Interact. |
pmid:22940207
|
Kittayaruksakul S et al. |
Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. |
2012 |
Am. J. Physiol. Renal Physiol. |
pmid:22169006
|
Tranheim Kase E et al. |
Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. |
2012 |
Lipids |
pmid:22426832
|
Valbuena-Diez AC et al. |
Oxysterol-induced soluble endoglin release and its involvement in hypertension. |
2012 |
Circulation |
pmid:23110859
|
Soodvilai S et al. |
Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. |
2012 |
Am. J. Physiol. Renal Physiol. |
pmid:23077096
|
Kumar R et al. |
Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. |
2012 |
Exp. Dermatol. |
pmid:23163651
|
Ortega I et al. |
Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. |
2012 |
Biol. Reprod. |
pmid:21918126
|
Cruz-Garcia L et al. |
Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. |
2011 |
Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. |
pmid:21635958
|
Mast N et al. |
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. |
2011 |
J. Biol. Chem. |
pmid:21159775
|
Escobar JC et al. |
The human placenta expresses CYP17 and generates androgens de novo. |
2011 |
J. Clin. Endocrinol. Metab. |
pmid:21307141
|
Mastrocola R et al. |
Dysregulation of SREBP2 induces BACE1 expression. |
2011 |
Neurobiol. Dis. |
pmid:21726644
|
Aye IL et al. |
Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. |
2011 |
Placenta |
pmid:21208656
|
Chuu CP and Lin HP |
Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. |
2010 |
Anticancer Res. |
pmid:20944148
|
Matsushita K et al. |
Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. |
2010 |
J. Biol. Chem. |
pmid:20118482
|
Chen W et al. |
Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. |
2010 |
Exp. Dermatol. |
pmid:20337700
|
Adachi T et al. |
Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. |
2009 Nov-Dec |
Mol. Pharm. |
pmid:19588995
|
Demerjian M et al. |
Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. |
2009 |
Exp. Dermatol. |
pmid:19236478
|
Arikan S and Yigit AA |
Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. |
2009 |
Anim. Reprod. Sci. |
pmid:19135321
|
Hynynen R et al. |
OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. |
2009 |
J. Lipid Res. |
pmid:19224871
|
Honda A et al. |
Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. |
2009 |
J. Lipid Res. |
pmid:18815436
|
Minagawa H et al. |
Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. |
2009 |
J. Neurosci. Res. |
pmid:19326444
|
Morello F et al. |
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. |
2009 |
Atherosclerosis |
pmid:19426978
|
Lee JH et al. |
Androgen deprivation by activating the liver X receptor. |
2008 |
Endocrinology |
pmid:18450964
|
Qu JH et al. |
Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. |
2008 |
Toxicol. Lett. |
pmid:18053657
|
Dodo K et al. |
Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. |
2008 |
Bioorg. Med. Chem. |
pmid:18343126
|
Bates SR et al. |
Expression and biological activity of ABCA1 in alveolar epithelial cells. |
2008 |
Am. J. Respir. Cell Mol. Biol. |
pmid:17884990
|
Ouimet M et al. |
Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. |
2008 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:18369155
|
Wang YB et al. |
Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). |
2007 |
J. Toxicol. Environ. Health Part A |
pmid:17479410
|
Yao ZX et al. |
22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. |
2007 |
Neuroscience |
pmid:17689017
|
Cheng S et al. |
Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. |
2006 |
Toxicology |
pmid:16413094
|
Deng R et al. |
Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. |
2006 |
J. Pharmacol. Exp. Ther. |
pmid:16371446
|
Kase ET et al. |
22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. |
2006 |
Biochim. Biophys. Acta |
pmid:17055780
|
Supornsilchai V et al. |
Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. |
2006 |
Reprod. Toxicol. |
pmid:16777379
|
Allen JA et al. |
Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. |
2006 |
Endocrinology |
pmid:16690799
|
Piraino G et al. |
Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. |
2006 |
Shock |
pmid:16878022
|
Poon SL et al. |
Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis. |
2005 |
Life Sci. |
pmid:15680312
|
Weedon-Fekjaer MS et al. |
Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line. |
2005 |
Placenta |
pmid:16226121
|
Shouhed D et al. |
Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. |
2005 |
J. Cell. Biochem. |
pmid:15880703
|
Norata GD et al. |
Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. |
2005 |
Int. J. Mol. Med. |
pmid:16142410
|
Yasuda T et al. |
Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages. |
2005 |
J. Steroid Biochem. Mol. Biol. |
pmid:16146692
|
Matsuzaki J et al. |
Immunosteroid as a regulator for Th1/Th2 balance: its possible role in autoimmune diseases. |
2005 |
Autoimmunity |
pmid:16227152
|
Hauet T et al. |
Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. |
2005 |
Mol. Endocrinol. |
pmid:15498831
|
Sriraman V and Jagannadha Rao A |
Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. |
2004 |
Mol. Cell. Endocrinol. |
pmid:15353182
|
Huuskonen J et al. |
Role of p160 coactivator complex in the activation of liver X receptor. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:14764426
|
Lecanu L et al. |
Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. |
2004 |
Steroids |
pmid:14715372
|
Dubuc G et al. |
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:15178557
|
Yoon JH et al. |
Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. |
2004 |
Hepatology |
pmid:14999691
|
Llaverias G et al. |
Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. |
2004 |
J. Lipid Res. |
pmid:15314095
|
Suzuki S et al. |
Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:14726413
|
Denis M et al. |
Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). |
2004 |
J. Biol. Chem. |
pmid:14660648
|
Schmuth M et al. |
The effect of LXR activators on AP-1 proteins in keratinocytes. |
2004 |
J. Invest. Dermatol. |
pmid:15191540
|
Haidar B et al. |
Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. |
2004 |
J. Biol. Chem. |
pmid:14701824
|
O'Connell BJ et al. |
Cellular physiology of cholesterol efflux in vascular endothelial cells. |
2004 |
Circulation |
pmid:15492319
|
Tang CK et al. |
Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. |
2004 |
Acta Pharmacol. Sin. |
pmid:15132822
|
Cheng J et al. |
The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. |
2003 |
Toxicology |
pmid:12699903
|
Hsu CC et al. |
Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. |
2003 |
FEBS Lett. |
pmid:12753921
|
Bortnick AE et al. |
Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. |
2003 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:12909583
|
Ide T et al. |
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. |
2003 |
Mol. Endocrinol. |
pmid:12730332
|
Koldamova RP et al. |
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. |
2003 |
J. Biol. Chem. |
pmid:12547833
|
Nguyen DH and Taub DD |
Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. |
2003 |
Exp. Cell Res. |
pmid:12706121
|
Fowler AJ et al. |
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. |
2003 |
J. Invest. Dermatol. |
pmid:12542530
|
Xia H and Redman CM |
Oxysterols suppress constitutive fibrinogen expression. |
2003 |
Thromb. Haemost. |
pmid:12876624
|
Antonio V et al. |
Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. |
2003 |
Biochem. J. |
pmid:12882648
|
Goodwin B et al. |
Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. |
2003 |
Mol. Endocrinol. |
pmid:12554795
|
Kaneko E et al. |
Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. |
2003 |
J. Biol. Chem. |
pmid:12847102
|
Nazarov PA et al. |
Formation and functioning of fused cholesterol side-chain cleavage enzymes. |
2003 |
DNA Cell Biol. |
pmid:12823901
|
Thiboutot D et al. |
Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). |
2003 |
J. Invest. Dermatol. |
pmid:12787114
|
Malerød L et al. |
Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:12470667
|
Yao ZX et al. |
22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. |
2002 |
J. Neurochem. |
pmid:12437582
|
Goldman JM and Murr AS |
Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway. |
2002 |
Toxicology |
pmid:11836015
|
Kömüves LG et al. |
Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. |
2002 |
J. Invest. Dermatol. |
pmid:11851872
|
Nishida Y et al. |
Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:11785958
|
Reddy ST et al. |
ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. |
2002 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:12426219
|
Stein O et al. |
Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:11820773
|
Wellington CL et al. |
Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. |
2002 |
J. Lipid Res. |
pmid:12401893
|
Ragoobir J et al. |
Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins. |
2002 |
J. Endocrinol. |
pmid:11927389
|