22(r)-hydroxycholesterol

22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.

Cross Reference

Introduction

To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 22(r)-hydroxycholesterol?

22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with 22(r)-hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 22(r)-hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 22(r)-hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 22(r)-hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 22(r)-hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 22(r)-hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 22(r)-hydroxycholesterol

Download all related citations
Per page 10 20 50 100 | Total 161
Authors Title Published Journal PubMed Link
Yoshida K et al. Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. 2018 Andrologia pmid:28295471
Yi M et al. Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. 2017 Toxicol. Appl. Pharmacol. pmid:28729181
Li J et al. Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis. 2017 Reprod. Biol. Endocrinol. pmid:28302174
Venugopal S et al. Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. 2016 J. Biol. Chem. pmid:27815506
Kim H et al. 22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. 2016 Biochim. Biophys. Acta pmid:27206966
Ceroi A et al. The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation. 2016 Haematologica pmid:26635040
Huwait EA et al. Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages. 2015 J. Cell. Biochem. pmid:25752819
Newby EA et al. Adrenocorticotropic Hormone and PI3K/Akt Inhibition Reduce eNOS Phosphorylation and Increase Cortisol Biosynthesis in Long-Term Hypoxic Ovine Fetal Adrenal Cortical Cells. 2015 Reprod Sci pmid:25656500
Na TY et al. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. 2015 J. Pathol. pmid:25557254
Davydov R et al. Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. 2015 Biochemistry pmid:26603348
Trompier D et al. Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. 2014 Biochem. Biophys. Res. Commun. pmid:24480443
Wang JM et al. 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. 2014 Biochem. Biophys. Res. Commun. pmid:24704452
Gondcaille C et al. LXR antagonists induce ABCD2 expression. 2014 Biochim. Biophys. Acta pmid:24239766
Slominski AT et al. In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. 2014 Mol. Cell. Endocrinol. pmid:24382416
Soodgupta D et al. Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes. 2014 Mol. Cell. Biochem. pmid:25283515
Mao D et al. ATF3 expression in the corpus luteum: possible role in luteal regression. 2013 Mol. Endocrinol. pmid:24196350
Høgmoen Åstrand OA et al. (2S,3S)-2,6-dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. 2013 Acta Crystallogr C pmid:23744388
Raccosta L et al. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. 2013 J. Exp. Med. pmid:23897983
Schaffer S et al. Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. 2013 Biochem. Pharmacol. pmid:23665353
Olala LO et al. A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. 2013 Mol. Cell. Endocrinol. pmid:23178798
El Roz A et al. LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. 2012 Anticancer Res. pmid:22753765
Papadopoulos V and Lecanu L Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. 2012 J. Neuroendocrinol. pmid:21623958
Hessvik NP et al. The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. 2012 J. Steroid Biochem. Mol. Biol. pmid:22051079
Lecanu L et al. A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. 2012 Steroids pmid:22138207
García MM et al. Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. 2012 Chem. Biol. Interact. pmid:22940207
Kittayaruksakul S et al. Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. 2012 Am. J. Physiol. Renal Physiol. pmid:22169006
Tranheim Kase E et al. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. 2012 Lipids pmid:22426832
Valbuena-Diez AC et al. Oxysterol-induced soluble endoglin release and its involvement in hypertension. 2012 Circulation pmid:23110859
Soodvilai S et al. Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. 2012 Am. J. Physiol. Renal Physiol. pmid:23077096
Kumar R et al. Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. 2012 Exp. Dermatol. pmid:23163651
Ortega I et al. Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. 2012 Biol. Reprod. pmid:21918126
Cruz-Garcia L et al. Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21635958
Mast N et al. Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. 2011 J. Biol. Chem. pmid:21159775
Escobar JC et al. The human placenta expresses CYP17 and generates androgens de novo. 2011 J. Clin. Endocrinol. Metab. pmid:21307141
Mastrocola R et al. Dysregulation of SREBP2 induces BACE1 expression. 2011 Neurobiol. Dis. pmid:21726644
Aye IL et al. Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. 2011 Placenta pmid:21208656
Chuu CP and Lin HP Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. 2010 Anticancer Res. pmid:20944148
Matsushita K et al. Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. 2010 J. Biol. Chem. pmid:20118482
Chen W et al. Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. 2010 Exp. Dermatol. pmid:20337700
Adachi T et al. Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. 2009 Nov-Dec Mol. Pharm. pmid:19588995
Demerjian M et al. Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. 2009 Exp. Dermatol. pmid:19236478
Arikan S and Yigit AA Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. 2009 Anim. Reprod. Sci. pmid:19135321
Hynynen R et al. OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. 2009 J. Lipid Res. pmid:19224871
Honda A et al. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. 2009 J. Lipid Res. pmid:18815436
Minagawa H et al. Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. 2009 J. Neurosci. Res. pmid:19326444
Morello F et al. LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. 2009 Atherosclerosis pmid:19426978
Lee JH et al. Androgen deprivation by activating the liver X receptor. 2008 Endocrinology pmid:18450964
Qu JH et al. Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. 2008 Toxicol. Lett. pmid:18053657
Dodo K et al. Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. 2008 Bioorg. Med. Chem. pmid:18343126
Bates SR et al. Expression and biological activity of ABCA1 in alveolar epithelial cells. 2008 Am. J. Respir. Cell Mol. Biol. pmid:17884990
Ouimet M et al. Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18369155
Wang YB et al. Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). 2007 J. Toxicol. Environ. Health Part A pmid:17479410
Yao ZX et al. 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. 2007 Neuroscience pmid:17689017
Cheng S et al. Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. 2006 Toxicology pmid:16413094
Deng R et al. Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. 2006 J. Pharmacol. Exp. Ther. pmid:16371446
Kase ET et al. 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. 2006 Biochim. Biophys. Acta pmid:17055780
Supornsilchai V et al. Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. 2006 Reprod. Toxicol. pmid:16777379
Allen JA et al. Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. 2006 Endocrinology pmid:16690799
Piraino G et al. Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. 2006 Shock pmid:16878022
Poon SL et al. Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis. 2005 Life Sci. pmid:15680312
Weedon-Fekjaer MS et al. Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line. 2005 Placenta pmid:16226121
Shouhed D et al. Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. 2005 J. Cell. Biochem. pmid:15880703
Norata GD et al. Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. 2005 Int. J. Mol. Med. pmid:16142410
Yasuda T et al. Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages. 2005 J. Steroid Biochem. Mol. Biol. pmid:16146692
Matsuzaki J et al. Immunosteroid as a regulator for Th1/Th2 balance: its possible role in autoimmune diseases. 2005 Autoimmunity pmid:16227152
Hauet T et al. Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. 2005 Mol. Endocrinol. pmid:15498831
Sriraman V and Jagannadha Rao A Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. 2004 Mol. Cell. Endocrinol. pmid:15353182
Huuskonen J et al. Role of p160 coactivator complex in the activation of liver X receptor. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14764426
Lecanu L et al. Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. 2004 Steroids pmid:14715372
Dubuc G et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15178557
Yoon JH et al. Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. 2004 Hepatology pmid:14999691
Llaverias G et al. Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. 2004 J. Lipid Res. pmid:15314095
Suzuki S et al. Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:14726413
Denis M et al. Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). 2004 J. Biol. Chem. pmid:14660648
Schmuth M et al. The effect of LXR activators on AP-1 proteins in keratinocytes. 2004 J. Invest. Dermatol. pmid:15191540
Haidar B et al. Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. 2004 J. Biol. Chem. pmid:14701824
O'Connell BJ et al. Cellular physiology of cholesterol efflux in vascular endothelial cells. 2004 Circulation pmid:15492319
Tang CK et al. Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. 2004 Acta Pharmacol. Sin. pmid:15132822
Cheng J et al. The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. 2003 Toxicology pmid:12699903
Hsu CC et al. Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. 2003 FEBS Lett. pmid:12753921
Bortnick AE et al. Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12909583
Ide T et al. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. 2003 Mol. Endocrinol. pmid:12730332
Koldamova RP et al. 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. 2003 J. Biol. Chem. pmid:12547833
Nguyen DH and Taub DD Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. 2003 Exp. Cell Res. pmid:12706121
Fowler AJ et al. Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. 2003 J. Invest. Dermatol. pmid:12542530
Xia H and Redman CM Oxysterols suppress constitutive fibrinogen expression. 2003 Thromb. Haemost. pmid:12876624
Antonio V et al. Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. 2003 Biochem. J. pmid:12882648
Goodwin B et al. Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. 2003 Mol. Endocrinol. pmid:12554795
Kaneko E et al. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. 2003 J. Biol. Chem. pmid:12847102
Nazarov PA et al. Formation and functioning of fused cholesterol side-chain cleavage enzymes. 2003 DNA Cell Biol. pmid:12823901
Thiboutot D et al. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). 2003 J. Invest. Dermatol. pmid:12787114
Malerød L et al. Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. 2002 Biochem. Biophys. Res. Commun. pmid:12470667
Yao ZX et al. 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. 2002 J. Neurochem. pmid:12437582
Goldman JM and Murr AS Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway. 2002 Toxicology pmid:11836015
Kömüves LG et al. Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. 2002 J. Invest. Dermatol. pmid:11851872
Nishida Y et al. Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. 2002 Biochem. Biophys. Res. Commun. pmid:11785958
Reddy ST et al. ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12426219
Stein O et al. Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice. 2002 Biochem. Biophys. Res. Commun. pmid:11820773
Wellington CL et al. Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. 2002 J. Lipid Res. pmid:12401893
Ragoobir J et al. Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins. 2002 J. Endocrinol. pmid:11927389