| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
Total
1
22(r)-hydroxycholesterol
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
Cross Reference
Introduction
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22(r)-hydroxycholesterol?
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22(r)-hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22(r)-hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 22(r)-hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22(r)-hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Høgmoen Åstrand OA et al. | (2S,3S)-2,6-dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. | 2013 | Acta Crystallogr C | pmid:23744388 |
| Huijmans JG et al. | Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. | 1981 | Acta Endocrinol. | pmid:6263029 |
| Huijmans JG et al. | Effects of some hydroxylated sterols on the steroid production in isolated rat adrenal glomerulosa and fasciculata/reticularis cells in the presence of potassium, angiotensin II or ACTH. | 1984 | Acta Endocrinol. | pmid:6322498 |
| Huijmans JG et al. | Conversion of 22S-hydroxy-cholesterol and its effects on the metabolism of other sterols in rat adrenal cells and bovine adrenal mitochondria. | 1982 | Acta Endocrinol. | pmid:6289587 |
| Tang CK et al. | Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. | 2004 | Acta Pharmacol. Sin. | pmid:15132822 |
| Carr BR and Mason JI | The effects of alpha-human atrial natriuretic polypeptide on steroidogenesis by fetal zone cells of the human fetal adrenal gland. | 1988 | Am. J. Obstet. Gynecol. | pmid:2849878 |
| Meikle AW et al. | Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. | 1989 | Am. J. Physiol. | pmid:2558577 |
| Bortnick AE et al. | Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12909583 |
| Kittayaruksakul S et al. | Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22169006 |
| Soodvilai S et al. | Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:23077096 |
| Bates SR et al. | Expression and biological activity of ABCA1 in alveolar epithelial cells. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:17884990 |
| Yoshida K et al. | Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. | 2018 | Andrologia | pmid:28295471 |
| Arikan S and Yigit AA | Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. | 2009 | Anim. Reprod. Sci. | pmid:19135321 |
| Bosc MJ and Nicolle A | Androstenedione and progesterone production in vitro by the inner or the outer theca cells in preovulatory follicles of gonadotropin stimulated calves. | 1998 | Anim. Reprod. Sci. | pmid:9672665 |
| El Roz A et al. | LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. | 2012 | Anticancer Res. | pmid:22753765 |
| Chuu CP and Lin HP | Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. | 2010 | Anticancer Res. | pmid:20944148 |
| Huuskonen J et al. | Role of p160 coactivator complex in the activation of liver X receptor. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14764426 |
| Dubuc G et al. | Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15178557 |
| Suzuki S et al. | Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14726413 |
| Reddy ST et al. | ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12426219 |
| Ouimet M et al. | Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18369155 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
| Matsuzaki J et al. | Immunosteroid as a regulator for Th1/Th2 balance: its possible role in autoimmune diseases. | 2005 | Autoimmunity | pmid:16227152 |
| Malerød L et al. | Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12470667 |
| Trompier D et al. | Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24480443 |
| Wang JM et al. | 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24704452 |
| Nishida Y et al. | Expression and functional analyses of novel mutations of ATP-binding cassette transporter-1 in Japanese patients with high-density lipoprotein deficiency. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11785958 |
| Huang CJ et al. | Synergistic activation of RLD-1 by agents triggering PKA and PKC dependent signalling. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9500983 |
| Stein O et al. | Macrophage cholesterol efflux to free apoprotein A-I in C3H and C57BL/6 mice. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11820773 |
| Lorkowski S et al. | Genomic sequence and structure of the human ABCG1 (ABC8) gene. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11162488 |
| Tu AY and Albers JJ | Functional analysis of the transcriptional activity of the mouse phospholipid transfer protein gene. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11573953 |
| Sullivan MH and Cooke BA | Stimulation of cholesterol side-chain cleavage by a luteinizing-hormone-releasing hormone (luliberin) agonist (ICI 118630) in rat Leydig cells. | 1983 | Biochem. J. | pmid:6230077 |
| Antonio V et al. | Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells. | 2003 | Biochem. J. | pmid:12882648 |
| Schaffer S et al. | Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. | 2013 | Biochem. Pharmacol. | pmid:23665353 |
| Abayasekara RE and Flint AP | A novel phospholipase C inhibitor U73122, inhibits phospholipase C-independent processes in rat luteal cells. | 1993 | Biochem. Soc. Trans. | pmid:8131934 |
| Davydov R et al. | Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. | 2015 | Biochemistry | pmid:26603348 |
| Kase ET et al. | 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. | 2006 | Biochim. Biophys. Acta | pmid:17055780 |
| Mele PG et al. | Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland. | 1996 | Biochim. Biophys. Acta | pmid:8599603 |
| Gondcaille C et al. | LXR antagonists induce ABCD2 expression. | 2014 | Biochim. Biophys. Acta | pmid:24239766 |
| Bates SR et al. | Prevention of the hyperlipidemic serum or LDL-induced cellular cholesterol ester accumulation by 22-hydroxycholesterol and its analogue. | 1983 | Biochim. Biophys. Acta | pmid:6615863 |
| Kim H et al. | 22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. | 2016 | Biochim. Biophys. Acta | pmid:27206966 |
| Ortega I et al. | Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. | 2012 | Biol. Reprod. | pmid:21918126 |
| Ogilvie KM et al. | The inhibitory effect of intracerebroventricularly injected interleukin 1beta on testosterone secretion in the rat: role of steroidogenic acute regulatory protein. | 1999 | Biol. Reprod. | pmid:9916024 |
| Stocco CO and Deis RP | Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy. | 1999 | Biol. Reprod. | pmid:10026123 |
| Dodo K et al. | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | 2008 | Bioorg. Med. Chem. | pmid:18343126 |
| GarcÃa MM et al. | Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. | 2012 | Chem. Biol. Interact. | pmid:22940207 |
| Valbuena-Diez AC et al. | Oxysterol-induced soluble endoglin release and its involvement in hypertension. | 2012 | Circulation | pmid:23110859 |
| O'Connell BJ et al. | Cellular physiology of cholesterol efflux in vascular endothelial cells. | 2004 | Circulation | pmid:15492319 |
| Cruz-Garcia L et al. | Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. | 2011 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:21635958 |