22(r)-hydroxycholesterol

22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.

Cross Reference

Introduction

To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 22(r)-hydroxycholesterol?

22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with 22(r)-hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 22(r)-hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 22(r)-hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 22(r)-hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 22(r)-hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 22(r)-hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 22(r)-hydroxycholesterol

Download all related citations
Per page 10 20 50 100 | Total 161
Authors Title Published Journal PubMed Link
pmid:
CHAUDHURI AC et al. Biosynthesis of pregnenolone from 22-hydroxycholesterol. 1962 J. Biol. Chem. pmid:13878470
Huijmans JG et al. Effects of 22S-hydroxy-cholesterol and other hydroxylated sterols on the ACTH-stimulated steroid production in rat adrenal cells. 1981 Acta Endocrinol. pmid:6263029
Huijmans JG et al. Conversion of 22S-hydroxy-cholesterol and its effects on the metabolism of other sterols in rat adrenal cells and bovine adrenal mitochondria. 1982 Acta Endocrinol. pmid:6289587
Sullivan MH and Cooke BA Stimulation of cholesterol side-chain cleavage by a luteinizing-hormone-releasing hormone (luliberin) agonist (ICI 118630) in rat Leydig cells. 1983 Biochem. J. pmid:6230077
Bates SR et al. Prevention of the hyperlipidemic serum or LDL-induced cellular cholesterol ester accumulation by 22-hydroxycholesterol and its analogue. 1983 Biochim. Biophys. Acta pmid:6615863
Huijmans JG et al. Effects of some hydroxylated sterols on the steroid production in isolated rat adrenal glomerulosa and fasciculata/reticularis cells in the presence of potassium, angiotensin II or ACTH. 1984 Acta Endocrinol. pmid:6322498
Risbridger GP et al. The interaction of hCG, hydroxysteroids and interstitial fluid on rat Leydig cell steroidogenesis in vitro. 1986 J. Reprod. Fertil. pmid:3723471
Carr BR and Mason JI The effects of alpha-human atrial natriuretic polypeptide on steroidogenesis by fetal zone cells of the human fetal adrenal gland. 1988 Am. J. Obstet. Gynecol. pmid:2849878
Cupp JR and Vickery LE Adrenodoxin with a COOH-terminal deletion (des 116-128) exhibits enhanced activity. 1989 J. Biol. Chem. pmid:2912975
Meikle AW et al. Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. 1989 Am. J. Physiol. pmid:2558577
Guo H et al. Interleukin-2 is a potent inhibitor of Leydig cell steroidogenesis. 1990 Endocrinology pmid:2167211
Hedger MP and Eddy EM Leydig cell cooperation in vitro: evidence for communication between adult rat Leydig cells. 1990 Jan-Feb J. Androl. pmid:2155894
Mauduit C et al. Tumor necrosis factor alpha inhibits gonadotropin action in cultured porcine Leydig cells: site(s) of action. 1991 Endocrinology pmid:1659519
Meikle AW et al. Extracellular calcium and luteinizing hormone effects on 22-hydroxycholesterol used for testosterone production in mouse Leydig cells. 1991 Mar-Apr J. Androl. pmid:2050582
Gocze PM and Freeman DA A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells. 1992 Endocrinology pmid:1332853
Fitz TA et al. Effects of substrate supplementation with hydroxycholesterol analogues and serum lipoproteins on ovine luteal cell progesterone secretion in vitro: demonstration of prostaglandin F2 alpha luteolytic actions in a defined model system. 1993 J. Reprod. Fertil. pmid:8464026
Abayasekara DR et al. Mode of action of prostaglandin F2 alpha in human luteinized granulosa cells: role of protein kinase C. 1993 Mol. Cell. Endocrinol. pmid:8143907
Abayasekara RE and Flint AP A novel phospholipase C inhibitor U73122, inhibits phospholipase C-independent processes in rat luteal cells. 1993 Biochem. Soc. Trans. pmid:8131934
Stocco DM et al. The effects of hydrogen peroxide on steroidogenesis in mouse Leydig tumor cells. 1993 Endocrinology pmid:8243310
Sourdaine P and Garnier DH Stage-dependent modulation of Sertoli cell steroid production in dogfish (Scyliorhinus canicula). 1993 J. Reprod. Fertil. pmid:8385221
Freeman DA et al. Finasteride blocks progesterone synthesis in MA-10 Leydig tumor cells. 1993 Endocrinology pmid:8404636
Boujrad N et al. Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam-binding inhibitor. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8390677
Musicki B et al. Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells. 1994 Endocrinology pmid:7507829
Khanna A et al. Heat shock protein induction blocks hormone-sensitive steroidogenesis in rat luteal cells. 1994 Steroids pmid:8140601
Picard-Hagen N et al. Glucocorticoids enhance the cholesterol side-chain cleavage activity of ovine adrenocortical mitochondria. 1995 J. Steroid Biochem. Mol. Biol. pmid:7577721
Brannian JD et al. Hydrogen peroxide suppresses low-density lipoprotein (LDL) uptake and LDL-supported steroidogenesis by porcine luteal cells. 1995 Mol. Cell. Endocrinol. pmid:7556884
Verhagen JC et al. Physical effects of biologically formed cholesterol oxidation products on lipid membranes investigated with fluorescence depolarization spectroscopy and electron spin resonance. 1996 J. Lipid Res. pmid:8827521
Mele PG et al. Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland. 1996 Biochim. Biophys. Acta pmid:8599603
Sugano S et al. Identification of intermediates in the conversion of cholesterol to pregnenolone with a reconstituted cytochrome p-450scc system: accumulation of the intermediate modulated by the adrenodoxin level. 1996 J. Biochem. pmid:8947841
Doris PA et al. Ouabain production by cultured adrenal cells. 1996 Endocrinology pmid:8593799
Pezzi V et al. Role of calmodulin-dependent protein kinase II in the acute stimulation of aldosterone production. 1996 J. Steroid Biochem. Mol. Biol. pmid:8903426
Janowski BA et al. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. 1996 Nature pmid:8878485
Hawi SR et al. Raman microspectroscopy of intracellular cholesterol crystals in cultured bovine coronary artery endothelial cells. 1997 J. Lipid Res. pmid:9300781
Lehmann JM et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. 1997 J. Biol. Chem. pmid:9013544
Lala DS et al. Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9144161
Marinero MJ et al. Specific effect of arachidonic acid on 17beta-hydroxysteroid dehydrogenase in rat Leydig cells. 1998 FEBS Lett. pmid:9475159
Huang CJ et al. Synergistic activation of RLD-1 by agents triggering PKA and PKC dependent signalling. 1998 Biochem. Biophys. Res. Commun. pmid:9500983
Lin T et al. Interferon-gamma inhibits the steroidogenic acute regulatory protein messenger ribonucleic acid expression and protein levels in primary cultures of rat Leydig cells. 1998 Endocrinology pmid:9564825
Lin T et al. Interleukin-1 inhibits Leydig cell steroidogenesis without affecting steroidogenic acute regulatory protein messenger ribonucleic acid or protein levels. 1998 J. Endocrinol. pmid:9582502
Bosc MJ and Nicolle A Androstenedione and progesterone production in vitro by the inner or the outer theca cells in preovulatory follicles of gonadotropin stimulated calves. 1998 Anim. Reprod. Sci. pmid:9672665
Dirami G and Cooke BA Effect of a dopamine agonist on luteinizing hormone receptors, cyclic AMP production and steroidogenesis in rat Leydig cells. 1998 Toxicol. Appl. Pharmacol. pmid:9653071
Cymeryng CB et al. Effects of L-arginine in rat adrenal cells: involvement of nitric oxide synthase. 1999 Endocrinology pmid:10385387
Hanley K et al. Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. 1999 J. Invest. Dermatol. pmid:10571735
Ogilvie KM et al. The inhibitory effect of intracerebroventricularly injected interleukin 1beta on testosterone secretion in the rat: role of steroidogenic acute regulatory protein. 1999 Biol. Reprod. pmid:9916024
Wiebel FF et al. Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer. 1999 Mol. Endocrinol. pmid:10406462
Stocco CO and Deis RP Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy. 1999 Biol. Reprod. pmid:10026123
Hanley K et al. Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. 2000 J. Invest. Dermatol. pmid:10692116
Costet P et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. 2000 J. Biol. Chem. pmid:10858438
Murono EP et al. Octylphenol inhibits testosterone biosynthesis by cultured precursor and immature Leydig cells from rat testes. 2000 May-Jun Reprod. Toxicol. pmid:10838129