| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
Total
1
22(r)-hydroxycholesterol
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
Cross Reference
Introduction
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22(r)-hydroxycholesterol?
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22(r)-hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22(r)-hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 22(r)-hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22(r)-hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yoshida K et al. | Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. | 2018 | Andrologia | pmid:28295471 |
| Yi M et al. | Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28729181 |
| Li J et al. | Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis. | 2017 | Reprod. Biol. Endocrinol. | pmid:28302174 |
| Venugopal S et al. | Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. | 2016 | J. Biol. Chem. | pmid:27815506 |
| Kim H et al. | 22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. | 2016 | Biochim. Biophys. Acta | pmid:27206966 |
| Ceroi A et al. | The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation. | 2016 | Haematologica | pmid:26635040 |
| Huwait EA et al. | Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages. | 2015 | J. Cell. Biochem. | pmid:25752819 |
| Newby EA et al. | Adrenocorticotropic Hormone and PI3K/Akt Inhibition Reduce eNOS Phosphorylation and Increase Cortisol Biosynthesis in Long-Term Hypoxic Ovine Fetal Adrenal Cortical Cells. | 2015 | Reprod Sci | pmid:25656500 |
| Na TY et al. | 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. | 2015 | J. Pathol. | pmid:25557254 |
| Davydov R et al. | Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. | 2015 | Biochemistry | pmid:26603348 |
| Trompier D et al. | Regulation of the adrenoleukodystrophy-related gene (ABCD2): focus on oxysterols and LXR antagonists. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24480443 |
| Wang JM et al. | 22(R)-hydroxycholesterol and pioglitazone synergistically decrease cholesterol ester via the PPARγ-LXRα-ABCA1 pathway in cholesterosis of the gallbladder. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24704452 |
| Gondcaille C et al. | LXR antagonists induce ABCD2 expression. | 2014 | Biochim. Biophys. Acta | pmid:24239766 |
| Slominski AT et al. | In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. | 2014 | Mol. Cell. Endocrinol. | pmid:24382416 |
| Soodgupta D et al. | Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes. | 2014 | Mol. Cell. Biochem. | pmid:25283515 |
| Mao D et al. | ATF3 expression in the corpus luteum: possible role in luteal regression. | 2013 | Mol. Endocrinol. | pmid:24196350 |
| Høgmoen Åstrand OA et al. | (2S,3S)-2,6-dimethylheptane-1,3-diol, the oxygenated side chain of 22(S)-hydroxycholestrol, and its synthetic precursor (R)-4-benzyl-3-[(2R,3S)-3-hydroxy-2,6-dimethylheptanoyl]-1,3-oxazolidin-2-one. | 2013 | Acta Crystallogr C | pmid:23744388 |
| Raccosta L et al. | The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. | 2013 | J. Exp. Med. | pmid:23897983 |
| Schaffer S et al. | Stereo specific platelet inhibition by the natural LXR agonist 22(R)-OH-cholesterol and its fluorescence labelling with preserved bioactivity and chiral handling in macrophages. | 2013 | Biochem. Pharmacol. | pmid:23665353 |
| Olala LO et al. | A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. | 2013 | Mol. Cell. Endocrinol. | pmid:23178798 |
| El Roz A et al. | LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. | 2012 | Anticancer Res. | pmid:22753765 |
| Papadopoulos V and Lecanu L | Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. | 2012 | J. Neuroendocrinol. | pmid:21623958 |
| Hessvik NP et al. | The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22051079 |
| Lecanu L et al. | A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. | 2012 | Steroids | pmid:22138207 |
| GarcÃa MM et al. | Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. | 2012 | Chem. Biol. Interact. | pmid:22940207 |
| Kittayaruksakul S et al. | Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22169006 |
| Tranheim Kase E et al. | Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. | 2012 | Lipids | pmid:22426832 |
| Valbuena-Diez AC et al. | Oxysterol-induced soluble endoglin release and its involvement in hypertension. | 2012 | Circulation | pmid:23110859 |
| Soodvilai S et al. | Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:23077096 |
| Kumar R et al. | Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. | 2012 | Exp. Dermatol. | pmid:23163651 |
| Ortega I et al. | Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. | 2012 | Biol. Reprod. | pmid:21918126 |
| Cruz-Garcia L et al. | Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes. | 2011 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:21635958 |
| Mast N et al. | Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. | 2011 | J. Biol. Chem. | pmid:21159775 |
| Escobar JC et al. | The human placenta expresses CYP17 and generates androgens de novo. | 2011 | J. Clin. Endocrinol. Metab. | pmid:21307141 |
| Mastrocola R et al. | Dysregulation of SREBP2 induces BACE1 expression. | 2011 | Neurobiol. Dis. | pmid:21726644 |
| Aye IL et al. | Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | 2011 | Placenta | pmid:21208656 |
| Chuu CP and Lin HP | Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines. | 2010 | Anticancer Res. | pmid:20944148 |
| Matsushita K et al. | Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. | 2010 | J. Biol. Chem. | pmid:20118482 |
| Chen W et al. | Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. | 2010 | Exp. Dermatol. | pmid:20337700 |
| Adachi T et al. | Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. | 2009 Nov-Dec | Mol. Pharm. | pmid:19588995 |
| Demerjian M et al. | Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. | 2009 | Exp. Dermatol. | pmid:19236478 |
| Arikan S and Yigit AA | Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries. | 2009 | Anim. Reprod. Sci. | pmid:19135321 |
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Minagawa H et al. | Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. | 2009 | J. Neurosci. Res. | pmid:19326444 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
| Qu JH et al. | Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. | 2008 | Toxicol. Lett. | pmid:18053657 |
| Dodo K et al. | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | 2008 | Bioorg. Med. Chem. | pmid:18343126 |
| Bates SR et al. | Expression and biological activity of ABCA1 in alveolar epithelial cells. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:17884990 |
| Ouimet M et al. | Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18369155 |