| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
Total
1
22(r)-hydroxycholesterol
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
Cross Reference
Introduction
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22(r)-hydroxycholesterol?
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22(r)-hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22(r)-hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 22(r)-hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22(r)-hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schmuth M et al. | The effect of LXR activators on AP-1 proteins in keratinocytes. | 2004 | J. Invest. Dermatol. | pmid:15191540 |
| Verhagen JC et al. | Physical effects of biologically formed cholesterol oxidation products on lipid membranes investigated with fluorescence depolarization spectroscopy and electron spin resonance. | 1996 | J. Lipid Res. | pmid:8827521 |
| Hynynen R et al. | OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. | 2009 | J. Lipid Res. | pmid:19224871 |
| Hawi SR et al. | Raman microspectroscopy of intracellular cholesterol crystals in cultured bovine coronary artery endothelial cells. | 1997 | J. Lipid Res. | pmid:9300781 |
| Llaverias G et al. | Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. | 2004 | J. Lipid Res. | pmid:15314095 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Wellington CL et al. | Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol. | 2002 | J. Lipid Res. | pmid:12401893 |
| Spencer TA et al. | Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. | 2001 | J. Med. Chem. | pmid:11300870 |
| Yao ZX et al. | 22R-Hydroxycholesterol protects neuronal cells from beta-amyloid-induced cytotoxicity by binding to beta-amyloid peptide. | 2002 | J. Neurochem. | pmid:12437582 |
| Papadopoulos V and Lecanu L | Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. | 2012 | J. Neuroendocrinol. | pmid:21623958 |
| Minagawa H et al. | Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. | 2009 | J. Neurosci. Res. | pmid:19326444 |
| Na TY et al. | 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. | 2015 | J. Pathol. | pmid:25557254 |
| Deng R et al. | Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16371446 |
| Risbridger GP et al. | The interaction of hCG, hydroxysteroids and interstitial fluid on rat Leydig cell steroidogenesis in vitro. | 1986 | J. Reprod. Fertil. | pmid:3723471 |
| Fitz TA et al. | Effects of substrate supplementation with hydroxycholesterol analogues and serum lipoproteins on ovine luteal cell progesterone secretion in vitro: demonstration of prostaglandin F2 alpha luteolytic actions in a defined model system. | 1993 | J. Reprod. Fertil. | pmid:8464026 |
| Sourdaine P and Garnier DH | Stage-dependent modulation of Sertoli cell steroid production in dogfish (Scyliorhinus canicula). | 1993 | J. Reprod. Fertil. | pmid:8385221 |
| Hessvik NP et al. | The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22051079 |
| Yasuda T et al. | Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:16146692 |
| Picard-Hagen N et al. | Glucocorticoids enhance the cholesterol side-chain cleavage activity of ovine adrenocortical mitochondria. | 1995 | J. Steroid Biochem. Mol. Biol. | pmid:7577721 |
| Pezzi V et al. | Role of calmodulin-dependent protein kinase II in the acute stimulation of aldosterone production. | 1996 | J. Steroid Biochem. Mol. Biol. | pmid:8903426 |
| Wang YB et al. | Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). | 2007 | J. Toxicol. Environ. Health Part A | pmid:17479410 |
| Poon SL et al. | Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis. | 2005 | Life Sci. | pmid:15680312 |
| Liu MY et al. | The inhibitory effects of lead on steroidogenesis in MA-10 mouse Leydig tumor cells. | 2001 | Life Sci. | pmid:11213355 |
| Tranheim Kase E et al. | Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. | 2012 | Lipids | pmid:22426832 |
| Soodgupta D et al. | Modulation of LXR-α and the effector genes by Ascorbic acid and Statins in psoriatic keratinocytes. | 2014 | Mol. Cell. Biochem. | pmid:25283515 |
| Yoshikawa T et al. | Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. | 2001 | Mol. Cell. Biol. | pmid:11287605 |
| Sriraman V and Jagannadha Rao A | Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. | 2004 | Mol. Cell. Endocrinol. | pmid:15353182 |
| Abayasekara DR et al. | Mode of action of prostaglandin F2 alpha in human luteinized granulosa cells: role of protein kinase C. | 1993 | Mol. Cell. Endocrinol. | pmid:8143907 |
| Slominski AT et al. | In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. | 2014 | Mol. Cell. Endocrinol. | pmid:24382416 |
| Brannian JD et al. | Hydrogen peroxide suppresses low-density lipoprotein (LDL) uptake and LDL-supported steroidogenesis by porcine luteal cells. | 1995 | Mol. Cell. Endocrinol. | pmid:7556884 |
| Olala LO et al. | A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models. | 2013 | Mol. Cell. Endocrinol. | pmid:23178798 |
| Ide T et al. | Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. | 2003 | Mol. Endocrinol. | pmid:12730332 |
| Mao D et al. | ATF3 expression in the corpus luteum: possible role in luteal regression. | 2013 | Mol. Endocrinol. | pmid:24196350 |
| Goodwin B et al. | Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. | 2003 | Mol. Endocrinol. | pmid:12554795 |
| Hauet T et al. | Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. | 2005 | Mol. Endocrinol. | pmid:15498831 |
| Wiebel FF et al. | Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer. | 1999 | Mol. Endocrinol. | pmid:10406462 |
| Adachi T et al. | Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells. | 2009 Nov-Dec | Mol. Pharm. | pmid:19588995 |
| Janowski BA et al. | An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. | 1996 | Nature | pmid:8878485 |
| Mastrocola R et al. | Dysregulation of SREBP2 induces BACE1 expression. | 2011 | Neurobiol. Dis. | pmid:21726644 |
| Yao ZX et al. | 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. | 2007 | Neuroscience | pmid:17689017 |
| Weedon-Fekjaer MS et al. | Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line. | 2005 | Placenta | pmid:16226121 |
| Aye IL et al. | Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors. | 2011 | Placenta | pmid:21208656 |
| Laffitte BA et al. | LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11149950 |
| DeBose-Boyd RA et al. | Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11171976 |
| Boujrad N et al. | Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam-binding inhibitor. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8390677 |
| Lala DS et al. | Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9144161 |
| Newby EA et al. | Adrenocorticotropic Hormone and PI3K/Akt Inhibition Reduce eNOS Phosphorylation and Increase Cortisol Biosynthesis in Long-Term Hypoxic Ovine Fetal Adrenal Cortical Cells. | 2015 | Reprod Sci | pmid:25656500 |
| Li J et al. | Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis. | 2017 | Reprod. Biol. Endocrinol. | pmid:28302174 |
| Supornsilchai V et al. | Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. | 2006 | Reprod. Toxicol. | pmid:16777379 |
| Murono EP et al. | Octylphenol inhibits testosterone biosynthesis by cultured precursor and immature Leydig cells from rat testes. | 2000 May-Jun | Reprod. Toxicol. | pmid:10838129 |
| Piraino G et al. | Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. | 2006 | Shock | pmid:16878022 |
| Lecanu L et al. | Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. | 2004 | Steroids | pmid:14715372 |
| Lecanu L et al. | A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. | 2012 | Steroids | pmid:22138207 |
| Khanna A et al. | Heat shock protein induction blocks hormone-sensitive steroidogenesis in rat luteal cells. | 1994 | Steroids | pmid:8140601 |
| Xia H and Redman CM | Oxysterols suppress constitutive fibrinogen expression. | 2003 | Thromb. Haemost. | pmid:12876624 |
| Yi M et al. | Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28729181 |
| Dirami G and Cooke BA | Effect of a dopamine agonist on luteinizing hormone receptors, cyclic AMP production and steroidogenesis in rat Leydig cells. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9653071 |
| Qu JH et al. | Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. | 2008 | Toxicol. Lett. | pmid:18053657 |
| Cheng J et al. | The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. | 2003 | Toxicology | pmid:12699903 |
| Cheng S et al. | Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. | 2006 | Toxicology | pmid:16413094 |
| Goldman JM and Murr AS | Alterations in ovarian follicular progesterone secretion by elevated exposures to the drinking water disinfection by-product dibromoacetic acid: examination of the potential site(s) of impact along the steroidogenic pathway. | 2002 | Toxicology | pmid:11836015 |