| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
Total
1
22(r)-hydroxycholesterol
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
Cross Reference
Introduction
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 22(r)-hydroxycholesterol?
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 22(r)-hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 22(r)-hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 22(r)-hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with 22(r)-hydroxycholesterol?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with 22(r)-hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fitz TA et al. | Effects of substrate supplementation with hydroxycholesterol analogues and serum lipoproteins on ovine luteal cell progesterone secretion in vitro: demonstration of prostaglandin F2 alpha luteolytic actions in a defined model system. | 1993 | J. Reprod. Fertil. | pmid:8464026 |
| Sourdaine P and Garnier DH | Stage-dependent modulation of Sertoli cell steroid production in dogfish (Scyliorhinus canicula). | 1993 | J. Reprod. Fertil. | pmid:8385221 |
| Boujrad N et al. | Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam-binding inhibitor. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8390677 |
| Musicki B et al. | Inhibition of protein synthesis and hormone-sensitive steroidogenesis in response to hydrogen peroxide in rat luteal cells. | 1994 | Endocrinology | pmid:7507829 |
| Khanna A et al. | Heat shock protein induction blocks hormone-sensitive steroidogenesis in rat luteal cells. | 1994 | Steroids | pmid:8140601 |
| Picard-Hagen N et al. | Glucocorticoids enhance the cholesterol side-chain cleavage activity of ovine adrenocortical mitochondria. | 1995 | J. Steroid Biochem. Mol. Biol. | pmid:7577721 |
| Brannian JD et al. | Hydrogen peroxide suppresses low-density lipoprotein (LDL) uptake and LDL-supported steroidogenesis by porcine luteal cells. | 1995 | Mol. Cell. Endocrinol. | pmid:7556884 |
| Verhagen JC et al. | Physical effects of biologically formed cholesterol oxidation products on lipid membranes investigated with fluorescence depolarization spectroscopy and electron spin resonance. | 1996 | J. Lipid Res. | pmid:8827521 |
| Mele PG et al. | Site of action of proteinases in the activation of steroidogenesis in rat adrenal gland. | 1996 | Biochim. Biophys. Acta | pmid:8599603 |
| Sugano S et al. | Identification of intermediates in the conversion of cholesterol to pregnenolone with a reconstituted cytochrome p-450scc system: accumulation of the intermediate modulated by the adrenodoxin level. | 1996 | J. Biochem. | pmid:8947841 |
| Doris PA et al. | Ouabain production by cultured adrenal cells. | 1996 | Endocrinology | pmid:8593799 |
| Pezzi V et al. | Role of calmodulin-dependent protein kinase II in the acute stimulation of aldosterone production. | 1996 | J. Steroid Biochem. Mol. Biol. | pmid:8903426 |
| Janowski BA et al. | An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. | 1996 | Nature | pmid:8878485 |
| Hawi SR et al. | Raman microspectroscopy of intracellular cholesterol crystals in cultured bovine coronary artery endothelial cells. | 1997 | J. Lipid Res. | pmid:9300781 |
| Lehmann JM et al. | Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. | 1997 | J. Biol. Chem. | pmid:9013544 |
| Lala DS et al. | Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9144161 |
| Huang CJ et al. | Synergistic activation of RLD-1 by agents triggering PKA and PKC dependent signalling. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9500983 |
| Lin T et al. | Interferon-gamma inhibits the steroidogenic acute regulatory protein messenger ribonucleic acid expression and protein levels in primary cultures of rat Leydig cells. | 1998 | Endocrinology | pmid:9564825 |
| Bosc MJ and Nicolle A | Androstenedione and progesterone production in vitro by the inner or the outer theca cells in preovulatory follicles of gonadotropin stimulated calves. | 1998 | Anim. Reprod. Sci. | pmid:9672665 |
| Dirami G and Cooke BA | Effect of a dopamine agonist on luteinizing hormone receptors, cyclic AMP production and steroidogenesis in rat Leydig cells. | 1998 | Toxicol. Appl. Pharmacol. | pmid:9653071 |