MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Bortnick AE et al. | Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12909583 |
Gocze PM and Freeman DA | A cholesteryl ester hydrolase inhibitor blocks cholesterol translocation into the mitochondria of MA-10 Leydig tumor cells. | 1992 | Endocrinology | pmid:1332853 |
CHAUDHURI AC et al. | Biosynthesis of pregnenolone from 22-hydroxycholesterol. | 1962 | J. Biol. Chem. | pmid:13878470 |
Denis M et al. | Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). | 2004 | J. Biol. Chem. | pmid:14660648 |
Haidar B et al. | Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. | 2004 | J. Biol. Chem. | pmid:14701824 |
Lecanu L et al. | Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. | 2004 | Steroids | pmid:14715372 |
Suzuki S et al. | Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14726413 |
Huuskonen J et al. | Role of p160 coactivator complex in the activation of liver X receptor. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14764426 |
Yoon JH et al. | Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. | 2004 | Hepatology | pmid:14999691 |
Tang CK et al. | Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages. | 2004 | Acta Pharmacol. Sin. | pmid:15132822 |