MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Dubuc G et al. | Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15178557 |
Schmuth M et al. | The effect of LXR activators on AP-1 proteins in keratinocytes. | 2004 | J. Invest. Dermatol. | pmid:15191540 |
Llaverias G et al. | Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. | 2004 | J. Lipid Res. | pmid:15314095 |
Sriraman V and Jagannadha Rao A | Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. | 2004 | Mol. Cell. Endocrinol. | pmid:15353182 |
O'Connell BJ et al. | Cellular physiology of cholesterol efflux in vascular endothelial cells. | 2004 | Circulation | pmid:15492319 |
Hauet T et al. | Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. | 2005 | Mol. Endocrinol. | pmid:15498831 |
Poon SL et al. | Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis. | 2005 | Life Sci. | pmid:15680312 |
Shouhed D et al. | Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. | 2005 | J. Cell. Biochem. | pmid:15880703 |
Norata GD et al. | Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. | 2005 | Int. J. Mol. Med. | pmid:16142410 |
Yasuda T et al. | Suppression of inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 22(R)-hydroxycholesterol requires de novo protein synthesis in activated macrophages. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:16146692 |