MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hsu CC et al. | Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. | 2003 | FEBS Lett. | pmid:12753921 |
Koldamova RP et al. | 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. | 2003 | J. Biol. Chem. | pmid:12547833 |
Fowler AJ et al. | Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. | 2003 | J. Invest. Dermatol. | pmid:12542530 |
Sriraman V and Jagannadha Rao A | Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation. | 2004 | Mol. Cell. Endocrinol. | pmid:15353182 |
Lecanu L et al. | Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity. | 2004 | Steroids | pmid:14715372 |
Dubuc G et al. | Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15178557 |
Yoon JH et al. | Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. | 2004 | Hepatology | pmid:14999691 |
Llaverias G et al. | Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. | 2004 | J. Lipid Res. | pmid:15314095 |
Schmuth M et al. | The effect of LXR activators on AP-1 proteins in keratinocytes. | 2004 | J. Invest. Dermatol. | pmid:15191540 |
O'Connell BJ et al. | Cellular physiology of cholesterol efflux in vascular endothelial cells. | 2004 | Circulation | pmid:15492319 |