MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Jung ME and Lui RM | Studies toward the total syntheses of cucurbitacins B and D. | 2010 | J. Org. Chem. | pmid:20873743 |
Chen W et al. | Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines. | 2010 | Int. J. Oncol. | pmid:20664943 |
Chan KT et al. | Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. | 2010 | Cancer Lett. | pmid:19700240 |
Nakashima S et al. | Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20347305 |
Yasuda S et al. | Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells. | 2010 | Mol Nutr Food Res | pmid:19937855 |
Liu T et al. | Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin. | 2010 | Eur. J. Pharmacol. | pmid:20483353 |
Dat NT et al. | An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB. | 2010 | J. Nat. Prod. | pmid:20469887 |
Chen C et al. | Cucurbitane-type triterpenoids from the stems of Cucumis melo. | 2009 | J. Nat. Prod. | pmid:19348465 |
Kongtun S et al. | Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. | 2009 | Planta Med. | pmid:19288406 |
Zhang M et al. | Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. | 2009 | Cancer Chemother. Pharmacol. | pmid:18521604 |