MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chen ZT et al. | Cucurbitacin B 2-sulfate and cucurbitacin glucosides from the root bark of Helicteres angustifolia. | 2006 | Chem. Pharm. Bull. | pmid:17077563 |
Dantas IN et al. | Studies on the cytotoxicity of cucurbitacins isolated from Cayaponia racemosa (Cucurbitaceae). | 2006 Sep-Oct | Z. Naturforsch., C, J. Biosci. | pmid:17137107 |
Deng J et al. | Small molecule inhibitors of Stat3 signaling pathway. | 2007 | Curr Cancer Drug Targets | pmid:17305481 |
Feng XS et al. | [Determination of the cucurbitacins from Cucubita pepo cv dayangua by HPLC]. | 2007 | Zhong Yao Cai | pmid:17674793 |
Molavi O et al. | Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. | 2008 | Int J Pharm | pmid:17681440 |
Tannin-Spitz T et al. | Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17942079 |
Liu T et al. | Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. | 2008 | Eur Arch Otorhinolaryngol | pmid:18309509 |
Haritunians T et al. | Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. | 2008 | Leuk. Res. | pmid:18405967 |
Liu T et al. | Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer. | 2008 | Eur. J. Pharmacol. | pmid:18442812 |
Zhang M et al. | Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. | 2009 | Cancer Chemother. Pharmacol. | pmid:18521604 |