MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
MeSH term | MeSH ID | Detail |
---|---|---|
Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Molavi O et al. | Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. | 2008 | Int J Pharm | pmid:17681440 |
Yin D et al. | Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme. | 2008 | Int. J. Cancer | pmid:18561312 |
Aribi A et al. | The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer. | 2013 | Int. J. Cancer | pmid:23165325 |
Chen W et al. | Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines. | 2010 | Int. J. Oncol. | pmid:20664943 |
Husen A and Siddiqi KS | Carbon and fullerene nanomaterials in plant system. | 2014 | J Nanobiotechnology | pmid:24766786 |
Arisawa M et al. | Plant anticancer agents. XXX: Cucurbitacins from Ipomopsis aggregata (Polemoniaceae). | 1984 | J Pharm Sci | pmid:6546946 |
Jianbo G et al. | The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: a PLGA particle system. | 2013 | J Pharm Sci | pmid:23729371 |
Jin HR et al. | Cucurbitacin B suppresses the transactivation activity of RelA/p65. | 2011 | J. Cell. Biochem. | pmid:21344491 |
Dakeng S et al. | Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus. | 2012 | J. Cell. Biochem. | pmid:21866566 |
Clericuzio M et al. | Cucurbitane triterpenoids from Leucopaxillus gentianeus. | 2004 | J. Nat. Prod. | pmid:15568769 |