| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
Total
2
Cucurbitacin B
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cucurbitacin B?
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
PubChem Associated disorders and diseases
What pathways are associated with Cucurbitacin B
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cucurbitacin B?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Cucurbitacin B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Cucurbitacin B?
There are no associated biomedical information in the current reference collection.
What genes are associated with Cucurbitacin B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Cucurbitacin B?
Xenograft Model
Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Cucurbitacin B
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
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| Zhang Y et al. | Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells. | 2011 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:21642275 |
| Ouyang D et al. | Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment. | 2011 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:21628505 |
| Zhang T et al. | Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis. | 2012 | Autophagy | pmid:22441021 |
| Tannin-Spitz T et al. | Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17942079 |
| Dinan L et al. | Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor. | 1997 | Biochem. J. | pmid:9581538 |
| Lang KL et al. | Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives. | 2012 | Bioorg. Med. Chem. | pmid:22472043 |
| Nakashima S et al. | Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20347305 |
| Kole C et al. | Nanobiotechnology can boost crop production and quality: first evidence from increased plant biomass, fruit yield and phytomedicine content in bitter melon (Momordica charantia). | 2013 | BMC Biotechnol. | pmid:23622112 |
| Duangmano S et al. | Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation. | 2012 | BMC Complement Altern Med | pmid:23062075 |
| Iwanski GB et al. | Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer. | 2010 | Br. J. Pharmacol. | pmid:20590594 |
| Lu P et al. | Cucurbitacin B regulates immature myeloid cell differentiation and enhances antitumor immunity in patients with lung cancer. | 2012 | Cancer Biother. Radiopharm. | pmid:22746287 |
| Zhang M et al. | Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. | 2009 | Cancer Chemother. Pharmacol. | pmid:18521604 |
| Chan KT et al. | Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. | 2010 | Cancer Lett. | pmid:19700240 |
| Lee DH et al. | Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma. | 2011 | Cancer Lett. | pmid:21440986 |
| Kausar H et al. | Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets. | 2013 | Cancer Lett. | pmid:23340170 |
| Gao Y et al. | Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth. | 2014 | Cancer Lett. | pmid:24690568 |
| Shukla S et al. | Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis. | 2015 | Cancer Prev Res (Phila) | pmid:25813524 |
| Thoennissen NH et al. | Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. | 2009 | Cancer Res. | pmid:19605406 |
| Wakimoto N et al. | Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo. | 2008 | Cancer Sci. | pmid:18627377 |
| Wu PL et al. | Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis. | 2004 | Chem. Pharm. Bull. | pmid:14993759 |
| Chen ZT et al. | Cucurbitacin B 2-sulfate and cucurbitacin glucosides from the root bark of Helicteres angustifolia. | 2006 | Chem. Pharm. Bull. | pmid:17077563 |
| Deng J et al. | Small molecule inhibitors of Stat3 signaling pathway. | 2007 | Curr Cancer Drug Targets | pmid:17305481 |
| Wang W et al. | Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability. | 2010 | Drug Deliv | pmid:20148709 |
| Hu H et al. | Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B. | 2013 | Drug Dev Ind Pharm | pmid:22794139 |