| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Total
2
Cucurbitacin B
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cucurbitacin B?
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
PubChem Associated disorders and diseases
What pathways are associated with Cucurbitacin B
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cucurbitacin B?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Cucurbitacin B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Cucurbitacin B?
There are no associated biomedical information in the current reference collection.
What genes are associated with Cucurbitacin B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Cucurbitacin B?
Xenograft Model
Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Cucurbitacin B
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu T et al. | Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. | 2008 | Eur Arch Otorhinolaryngol | pmid:18309509 |
| Shang Y et al. | Cucurbitacin-B inhibits neuroblastoma cell proliferation through up-regulation of PTEN. | 2014 | Eur Rev Med Pharmacol Sci | pmid:25487942 |
| Liu T et al. | Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin. | 2010 | Eur. J. Pharmacol. | pmid:20483353 |
| Ma J et al. | Cucurbitacin B inhibits the translational expression of hypoxia-inducible factor-1α. | 2014 | Eur. J. Pharmacol. | pmid:24333213 |
| Liu T et al. | Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer. | 2008 | Eur. J. Pharmacol. | pmid:18442812 |
| Toker G et al. | Callus formation and cucurbitacin B accumulation in Ecballium elaterium callus cultures. | 2003 | Fitoterapia | pmid:14630164 |
| Seo CR et al. | Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling. | 2014 | Food Chem. Toxicol. | pmid:24316209 |
| Duportets L et al. | Steroid hormone signaling is involved in the age-dependent behavioral response to sex pheromone in the adult male moth Agrotis ipsilon. | 2013 | Gen. Comp. Endocrinol. | pmid:23474331 |
| Duangmano S et al. | Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycle. | 2010 | Int J Mol Sci | pmid:21614210 |
| Lv Q et al. | Application of spray granulation for conversion of mixed phospholipid-bile salt micelles to dry powder form: influence of drug hydrophobicity on nanoparticle reagglomeration. | 2014 | Int J Nanomedicine | pmid:24531119 |