| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lung Neoplasms | D008175 | 171 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
Total
2
Cucurbitacin B
Cucurbitacin b is a lipid of Sterol Lipids (ST) class. Cucurbitacin b is associated with abnormalities such as Morphologically altered structure. The involved functions are known as Signal Transduction, Apoptosis, Cell Cycle Arrest, Cell Cycle and Negative Regulation of Mitosis. Cucurbitacin b often locates in Mediastinum and Pseudopodia. The associated genes with Cucurbitacin B are STAT5A gene, JAK2 gene, STAT3 gene, CDKN1A gene and BCL2L1 gene. The related experimental models are Xenograft Model.
Cross Reference
Introduction
To understand associated biological information of Cucurbitacin B, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cucurbitacin B?
Cucurbitacin B is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cucurbitacin B
PubChem Associated disorders and diseases
What pathways are associated with Cucurbitacin B
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin B through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cucurbitacin B?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Cucurbitacin B?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Cucurbitacin B?
There are no associated biomedical information in the current reference collection.
What genes are associated with Cucurbitacin B?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Cucurbitacin B?
Xenograft Model
Xenograft Model are used in the study 'Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.' (Thoennissen NH et al., 2009).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Cucurbitacin B
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang LQ and Yao ST | [Studies on the chemical constituents of Trichosanthes hupehensis C.Y. Cheng et Yueh]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8011097 |
| Wei Y et al. | [Studies on chemical constituents in roots of Helicteres angustifolia]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21842648 |
| Yu C et al. | [Preparation and characterization of cucurbitacin B sodium deoxycholate/phospholipid-mixed oral fast dissolving film and antitumor activity study]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:25282885 |
| Feng XS et al. | [Determination of the cucurbitacins from Cucubita pepo cv dayangua by HPLC]. | 2007 | Zhong Yao Cai | pmid:17674793 |
| Dantas IN et al. | Studies on the cytotoxicity of cucurbitacins isolated from Cayaponia racemosa (Cucurbitaceae). | 2006 Sep-Oct | Z. Naturforsch., C, J. Biosci. | pmid:17137107 |
| Kim SH et al. | Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells. | 2017 | Tumour Biol. | pmid:28218042 |
| Shukla S et al. | Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis. | 2016 | Sci Rep | pmid:26905250 |
| Promkan M et al. | The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells. | 2013 | PLoS ONE | pmid:23393598 |
| Guo J et al. | Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner. | 2014 | PLoS ONE | pmid:24505404 |
| Silva IT et al. | In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. | 2015 | PLoS ONE | pmid:25674792 |